The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Multiple loci associated with indices of renal function and chronic kidney disease
Open accessAbstract
Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1.73 m2) in European-ancestry participants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and tested for replication in 21,466 participants (1,932 CKD cases). We identified significant SNP associations (P < 5 × 10−8) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1. UMOD encodes the most common protein in human urine, Tamm-Horsfall protein, and rare mutations in UMOD cause mendelian forms of kidney disease. Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease.
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Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
Prevalence of Chronic Kidney Disease in the United States
Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007) · JAMA · doi:10.1001/jama.298.17.2038 · Cited by 4,895
Self-citationAssessing Kidney Function — Measured and Estimated Glomerular Filtration Rate
Stevens, L. A., Coresh, J., Greene, T., & Levey, A. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054415 · Cited by 2,952
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Eckardt, K.-U., Coresh, J., Devuyst, O., Johnson, R. J., Köttgen, A., Levey, A. S., & Levin, A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60439-0 · Cited by 1,159
Self-citationNew loci associated with kidney function and chronic kidney disease
Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., et al. (2010) · Nature Genetics · doi:10.1038/ng.568 · Cited by 804
Self-citationA genome-wide perspective of genetic variation in human metabolism
Illig, T., Gieger, C., Zhai, G., Römisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmüller, G., Kato, B. S., Mewes, H.-W., et al. (2010) · Nature Genetics · doi:10.1038/ng.507 · Cited by 653
Metadata
- Authors
- Köttgen, A., Glazer, N. L., Dehghan, A., Hwang, S.-J., Katz, R., Li, M., Yang, Q., Gudnason, V., Launer, L. J., Harris, T. B., Smith, A. V., Arking, D. E., Astor, B. C., Boerwinkle, E., Ehret, G. B., Ruczinski, I., Scharpf, R. B., Ida Chen, Y.-D., de Boer, I. H., Haritunians, T., Lumley, T., Sarnak, M., Siscovick, D., Benjamin, E. J., Levy, D., Upadhyay, A., Aulchenko, Y. S., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., van Duijn, C. M., Chasman, D. I., Paré, G., Ridker, P. M., Kao, W. H. L., Witteman, J. C., Coresh, J., Shlipak, M. G., & Fox, C. S.
- Venue
- Nature Genetics
- Published
- 2009-05-10
- Volume
- 41
- Issue
- 6
- Pages
- 712-717
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1967490910
- Cited by
- 647
- References
- 3
- FWCI
- 24.42
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Köttgen, A., Glazer, N. L., Dehghan, A., Hwang, S.-J., Katz, R., Li, M., Yang, Q., Gudnason, V., Launer, L. J., Harris, T. B., Smith, A. V., Arking, D. E., Astor, B. C., Boerwinkle, E., Ehret, G. B., Ruczinski, I., Scharpf, R. B., Ida Chen, Y.-D., de Boer, I. H., . . . Fox, C. S. (2009). Multiple loci associated with indices of renal function and chronic kidney disease. Nature Genetics. https://doi.org/10.1038/ng.377
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
