Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

23andMe Research Team, Ferreira, Manuel A, AAGC collaborators, BIOS consortium, LifeLines Cohort Study, Vonk, Judith M, Baurecht, Hansjörg, Marenholz, Ingo +62 more·2017·Nature Genetics

DOI 10.1038/ng.3985

Cited by (565)

Items 101–200 of 565

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Anna S. E. Cuomo, Daniel D. Seaton, Davis James McCarthy, Iker Martinez, Marc Jan Bonder, José Garcia‐Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Global differences in atopic dermatitis
Noor H. A. Suaini, Cheryl Pei Ting Tan, Evelyn Xiu Ling Loo, Elizabeth Huiwen Tham · 2020 · Pediatric Allergy and Immunology
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells
Rabab Nasrallah, Charlotte J. Imianowski, Lara Bossini‐Castillo, Francis M. Grant, Mikail Dogan, Lindsey Placek, Lina Kozhaya, Paula Kuo, Firas Sadiyah, Sarah K. Whiteside et al. · 2020 · Nature
Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study
Elise M. A. Slob, Bronwyn K. Brew, Susanne J. H. Vijverberg, Chantal J. A. R. Kats, Cristina Longo, Marielle W. H. Pijnenburg, Toos C.E.M. van Beijsterveldt, Conor V. Dolan, Meike Bartels, Patrick Magnusson et al. · 2020 · European Respiratory Journal
Age-of-onset information helps identify 76 genetic variants associated with allergic disease
Manuel A. R. Ferreira, Judith M. Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu et al. · 2020 · PLoS Genetics
A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
Wei Liu, Åsa Johansson, Helge Rask‐Andersen, Mathias Rask‐Andersen · 2021 · BMC Medicine
Genetics of chronic respiratory disease
Ian Sayers, Catherine John, Jing Chen, Ian P. Hall · 2024 · Nature Reviews Genetics
Meta-analysis of airway epithelium gene expression in asthma
Yi‐Hsuan Tsai, Joel S. Parker, Ivana V. Yang, Samir N. P. Kelada · 2018 · European Respiratory Journal
Phenotypic and functional translation of IL33 genetics in asthma
Maria E. Ketelaar, Michael A. Portelli, F. Nicole Dijk, Nick R. G. Shrine, Alen Faiz, Cornelis Joseph Vermeulen, Cheng‐Jian Xu, Jenny Hankinson, Sangita K. Bhaker, Amanda P. Henry et al. · 2020 · Journal of Allergy and Clinical Immunology
Allergic disease trajectories up to adolescence: Characteristics, early‐life, and genetic determinants
Anna Kilanowski, Elisabeth Thiering, Gang Wang, Ashish Kumar, Sara Kress, Claudia Flexeder, Carl‐Peter Bauer, Dietrich Berdel, Andrea v. Berg, Anna Bergström et al. · 2022 · Allergy
Identification of 22 novel loci associated with urinary biomarkers of albumin, sodium, and potassium excretion
Daniela Zanetti, Abhiram S. Rao, Stefan Gustafsson, Themistocles L. Assimes, Stephen B. Montgomery, Erik Ingelsson · 2019 · Kidney International
Omics for the future in asthma
Mahmoud I. Abdel‐Aziz, Anne H. Neerincx, Susanne J. H. Vijverberg, Aletta D. Kraneveld, Anke H. Maitland‐van der Zee · 2020 · Seminars in Immunopathology
Multiancestral polygenic risk score for pediatric asthma
Bahram Namjou, Michael Lape, Edyta Małolepsza, Stanley B. DeVore, Matthew T. Weirauch, Ozan Dikilitas, Gail Pairitz Jarvik, Krzysztof Kiryluk, Iftikhar Kullo, Cong Liu et al. · 2022 · Journal of Allergy and Clinical Immunology
Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics
Joana A. Revez, Lisa Bain, Rick M. Watson, Michelle A. Towers, Tina Collins, Kieran J. Killian, Paul M. O’Byrne, Gail M. Gauvreau, John W. Upham, Manuel A. R. Ferreira · 2019 · Clinical & Translational Immunology
Genetics and epigenetics of chronic rhinosinusitis
Devyani Lal, Tripti K. Brar, Shreya Pusapadi Ramkumar, Jingyun Li, Atsushi Kato, Luo Zhang · 2023 · Journal of Allergy and Clinical Immunology
Integrating multi‐omics approaches in deciphering atopic dermatitis pathogenesis and future therapeutic directions
Saeko Nakajima, Satoshi Nakamizo, Takashi Nomura, Yoshihiro Ishida, Yu Sawada, Kenji Kabashima · 2024 · Allergy
Genetic Associations and Architecture of Asthma-COPD Overlap
Catherine John, Anna L. Guyatt, Nick R. G. Shrine, Richard J. Packer, Thorunn Asta Olafsdottir, Jiangyuan Liu, Lystra P. Hayden, Su H. Chu, Jukka T. Koskela, Jian’an Luan et al. · 2022 · CHEST Journal
Allergies to food and airborne allergens in children and adolescents: role of epigenetics in a changing environment.
E. Mélen, G. Koppelman, A. Vicedo-Cabrera, Zorana Jovanovic Andersen, S. Bunyavanich · 2022 · The Lancet Child & Adolescent Health
Nasal DNA methylation at three CpG sites predicts childhood allergic disease
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper‐Emil Tingskov Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Bügel, Orestes A. Carpaij et al. · 2022 · Nature Communications
New Directions in Understanding Atopic March Starting from Atopic Dermatitis
Nunzia Maiello, Pasquale Comberiati, Arianna Giannetti, Giampaolo Ricci, Rossella Carello, Elena Galli · 2022 · Children
Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
Marcus M. Soliai, Atsushi Kato, Britney A. Helling, Catherine T. Stanhope, James E. Norton, Katherine A. Naughton, Aiko I. Klinger, Emma E. Thompson, Selene M. Clay, Soyeon Kim et al. · 2021 · Genome Medicine
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
Bretherick, Andrew D., Canela-Xandri, Oriol, Joshi, Peter K., Clark, David W., Rawlik, Konrad, Boutin, Thibaud S., Zeng, Yanni, Amador, Carmen, Navarro, Pau, Rudan, Igor et al. · 2020 · PLOS Genetics
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation
Dafni A. Glinos, Blagoje Soskic, Cayman Williams, Alan Kennedy, Luke Jostins, David Michael Sansom, Gosia Trynka · 2020 · Genes and Immunity
Might biologics serve to interrupt the atopic march?
Jonathan M. Spergel, George Du Toit, Carla McGuire Davis · 2023 · Journal of Allergy and Clinical Immunology
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
Michael A. Portelli, F. Nicole Dijk, Maria E. Ketelaar, Nick R. G. Shrine, Jenny Hankinson, Sangita K. Bhaker, Néomi S. Grotenboer, Ma’en Obeidat, Amanda P. Henry, Charlotte K. Billington et al. · 2020 · JCI Insight
Epigenome-wide association studies of allergic disease and the environment
Andrés Cárdenas, Raj P. Fadadu, Gerard H. Koppelman · 2023 · Journal of Allergy and Clinical Immunology
Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis
Hannah Clark, Raquel Granell, John A. Curtin, Danielle C. M. Belgrave, Angela Simpson, Clare S Murray, A. John Henderson, Adnan Čustović, Lavinia Paternoster · 2019 · Clinical & Experimental Allergy
Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
Anet Laanesoo, Alar Aab, Jerzy Soja, Krzysztof Sładek, Marek Sanak, Alan Altraja, Bogdan Jakieła, Grażyna Bochenek, Ana Rebane · 2019 · Clinical and Translational Allergy
Shared DNA methylation signatures in childhood allergy: The MeDALL study
Cheng‐Jian Xu, Olena Gruzieva, Cancan Qi, Ana Esplugues, Ulrike Gehring, Anna Bergström, Dan Mason, Leda Chatzi, Daniela Porta, Karin C. Lødrup Carlsen et al. · 2020 · Journal of Allergy and Clinical Immunology
A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma
Mathias Seviiri, Matthew H. Law, Jue‐Sheng Ong, Puya Gharahkhani, Pierre Fontanillas, Stella W. Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg et al. · 2022 · Nature Communications
Investigating the causal relationship between allergic disease and mental health
Ashley Budu‐Aggrey, Sally Joyce, Neil M Davies, Lavinia Paternoster, Marcus Robert Munafo, Sara Brown, Jonathan Evans, Hannah Sallis · 2021 · Clinical & Experimental Allergy
Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
Shuai Yuan, Lili Yu, Wanglong Gou, Lijuan Wang, Jing Sun, Doudou Li, Ying Lü, Xiaxia Cai, Huanling Yu, Changzheng Yuan et al. · 2022 · EBioMedicine
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression
Mucha, Sören, Baurecht, Hansjörg, Novak, Natalija, Rodríguez, Elke, Bej, Saptarshi, Mayr, Gabriele, Emmert, Hila, Stölzl, Dora, Gerdes, Sascha, Jung, Eun Suk et al. · 2020 · Journal of Allergy and Clinical Immunology
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
Matthew R. Lincoln, Noah Connally, Pierre‐Paul Axisa, Christiane Gasperi, Mitja Mitrovič, David A. van Heel, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers, Leonid Padyukov et al. · 2024 · Nature Genetics
Recent developments and highlights in immune monitoring of allergen immunotherapy
Menno C. van Zelm, Craig I. McKenzie, Nirupama P. Varese, Jennifer M. Rolland, Robyn E. O’Hehir · 2019 · Allergy
Atopy as Immune Dysregulation: Offender Genes and Targets
Maryam Vaseghi‐Shanjani, Andrew L. Snow, David J. Margolis, Meriem Latrous, Joshua D. Milner, Stuart E. Turvey, Catherine M. Biggs · 2022 · The Journal of Allergy and Clinical Immunology In Practice
Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank
Mark Gibson, Debbie A. Lawlor, Louise A C Millard · 2023 · BMC Medicine
Review article: Emerging insights into the epidemiology, pathophysiology, diagnostic and therapeutic aspects of eosinophilic oesophagitis and other eosinophilic gastrointestinal diseases
Eric Edison Low, Evan S. Dellon · 2023 · Alimentary Pharmacology & Therapeutics
CoMM: a collaborative mixed model to dissecting genetic contributions to complex traits by leveraging regulatory information
Can Yang, Xiang Wan, Xinyi Lin, Mengjie Chen, Xiang Zhou, Jin Liu · 2018 · Bioinformatics
Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study
Yi‐Qian Sun, Ben Michael Brumpton, Arnulf Langhammer, Yue Chen, Kirsti Kvaløy, Xiao‐Mei Mai · 2019 · Thorax
Bioinformatics Analysis and Identification of Underlying Biomarkers Potentially Linking Allergic Rhinitis and Asthma
Zhanfeng Yan, Lili Liu, Lulu Jiao, Xiaohui Wen, Jianhua Liu, Ningyu Wang · 2020 · Medical Science Monitor
Topical corticosteroids normalize both skin and systemic inflammatory markers in infant atopic dermatitis
Maeve A. McAleer, Ivone Jakaša, Nicholas Stefanovic, W.H. Irwin McLean, Sanja Kežić, Alan David Irvine · 2020 · British Journal of Dermatology
Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms
Samuel Mathieu, Mewen Briend, Erik Abner, Christian Yves Couture, Zhonglin Li, Yohan Bossé, Sébastien Thériault, Tõnu Esko, Benoît J. Arsenault, Patrick Mathieu · 2022 · iScience
Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine
Yan Hao, Yujuan Yang, Hongfei Zhao, Ying Chen, Ting Zuo, Yu Zhang, Hang Yu, Limei Cui, Xicheng Song · 2025 · Clinical Reviews in Allergy & Immunology
Epigenetic factors involved in the pathophysiology of inflammatory skin diseases
Lena Möbus, Stephan Weidinger, Hila Emmert · 2020 · Journal of Allergy and Clinical Immunology
Asthma and all-cause mortality in children and young adults: a population-based study
Emma Caffrey Osvald, Hannah Bower, Cecilia Lundholm, Henrik Larsson, Bronwyn K. Brew, Catarina Almqvist · 2020 · Thorax
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa
Anu Laulajainen‐Hongisto, Annina Lyly, Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Risto Renkonen, Kati M. Donner, Pirkko Mattila, Tuomas T. Jartti, Jean Bousquet et al. · 2020 · Clinical and Translational Allergy
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Sarah Grosche, Ingo Marenholz, Jorge Esparza-Gordillo, Aleix Arnau‐Soler, Erola Pairo‐Castineira, Franz Rüschendorf, Tarunveer S. Ahluwalia, Catarina Almqvist, Andreas Arnold, Hansjörg Baurecht et al. · 2021 · Nature Communications
Atopic dermatitis trajectories to age 8 years in the GUSTO cohort
Noor H. A. Suaini, Gaik Chin Yap, Do Phuong Tung Bui, Evelyn Xiu Ling Loo, Anne Eng Neo Goh, Oon Hoe Teoh, Kok Hian Tan, Keith M. Godfrey, Bee Wah Lee, Lynette Pei‐Chi Shek et al. · 2021 · Clinical & Experimental Allergy
What Have We Learned from GWAS for Atopic Dermatitis?
Sara Brown · 2020 · Journal of Investigative Dermatology
The causal association of polyunsaturated fatty acids with allergic disease: A two-sample Mendelian randomization study
Yajia Li, Qiangxiang Li, Ziqin Cao, Jianhuang Wu · 2022 · Frontiers in Nutrition
Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey
Juha Jantunen, Tari Haahtela, Johanna Salimäki, Miika Linna, Mika Juhani Mäkelä, Anna Susanna Pelkonen, Paula Kauppi · 2019 · International Archives of Allergy and Immunology
A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology
Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao, Janine Collins, Kate Downes, Luigi Grassi et al. · 2023 · Nature Communications
Shared Genetic Liability Between Major Depressive Disorder and Atopic Diseases
Hongbao Cao, Sheng Li, Ancha V. Baranova, Fuquan Zhang · 2021 · Frontiers in Immunology
Increasing severity of early‐onset atopic dermatitis, but not late‐onset, associates with development of aeroallergen sensitization and allergic rhinitis in childhood
Ann‐Marie Malby Schoos, Bo Chawes, Klaus Bønnelykke, Jakob Stokholm, Morten Arendt Rasmussen, Hans Flinker Bisgaard · 2021 · Allergy
Treatable Traits in Asthma: The Importance of Extrapulmonary Traits—GERD, CRSwNP, Atopic Dermatitis, and Depression/Anxiety
Vanessa M. McDonald, Yuto Hamada, Alvar G.N. Agustí, Peter G. Gibson · 2024 · The Journal of Allergy and Clinical Immunology In Practice
Relationship between birth weight or fetal growth rate and postnatal allergy: A systematic review
Amy L. Wooldridge, Mark McMillan, Manpreet Kaur, Lynne C. Giles, Helen Siobhan Marshall, Kathryn L. Gatford · 2019 · Journal of Allergy and Clinical Immunology
Molecular Mechanisms of Eosinophilic Esophagitis
Yury V. Zhernov, Соня Олеговна Высочанская, Vitaly A. Sukhov, Olga K. Zaostrovtseva, Denis S. Gorshenin, Ekaterina A. Sidorova, Oleg V. Mitrokhin · 2021 · International Journal of Molecular Sciences
Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update
Jessica Gambardella, Angela Lombardi, Marco Bruno Morelli, John Ferrara, Gaetano Santulli · 2020 · Journal of Clinical Medicine
Technological readiness and implementation of genomic‐driven precision medicine for complex diseases
Paul W. Franks, Erik Melén, Mikaela Friedman, Johan Sundström, Ingrid Skelton Kockum, Lars Klareskog, Catarina Almqvist, Sarah E. Bergen, Kamila Czene, Sara Hägg et al. · 2021 · Journal of Internal Medicine
Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease
Yu Xu, Dragana Vuckovic, Scott C. Ritchie, Parsa Akbari, Tao Jiang, Jason Grealey, Adam S. Butterworth, Willem Hendrik Ouwehand, David J. Roberts, Emanuele Di Angelantonio et al. · 2022 · Cell Genomics
Climate change and epigenetic biomarkers in allergic and airway diseases
Andrés Cárdenas, Raj P. Fadadu, Supinda Bunyavanich · 2023 · Journal of Allergy and Clinical Immunology
Pyroptosis, gasdermins and allergic diseases
Ronald Allan M. Panganiban, Kari Christine Nadeau, Quan Lu · 2024 · Allergy
The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases
Can Zeyneloglu, Huseyn Babayev, İsmail Öğülür, Sena Ardıçlı, Yağız Pat, Duygu Yazıcı, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D’Avino et al. · 2025 · FEBS Letters
Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C
Jeanette E. Eckel‐Passow, Kristen L. Drucker, Thomas M. Kollmeyer, Matthew Kosel, Paul A. Decker, Annette M. Molinaro, Terri Rice, Corinne E. Praska, Lauren E. Clark, Alissa A. Caron et al. · 2020 · Neuro-Oncology
Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors
Christopher H. Arehart, Michelle Daya, Monica Campbell, Meher Preethi Boorgula, Nicholas M. Rafaels, Sameer Chavan, Gloria L. David, Jon M. Hanifin, Mark K. Slifka, Richard L. Gallo et al. · 2021 · Journal of Allergy and Clinical Immunology
An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?
Margot K. Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Zharko Daniloski, John A. Morris, Veit Hornung et al. · 2021 · PLoS Genetics
Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories
Gabryszewski, Stanislaw J., Chang, Xiao, Dudley, Jesse W., Mentch, Frank, March, Michael, Holmes, John H., Moore, Jason, Grundmeier, Robert W., Hakonarson, Hakon, Hill, David A. · 2021 · Journal of Allergy and Clinical Immunology
An integrated approach to identify environmental modulators of genetic risk factors for complex traits
Brunilda Balliu, Ivan Carcamo‐Orive, Michael J. Gloudemans, Daniel C. Nachun, Matthew G. Durrant, Steven Gazal, Chong Yon Park, David A. Knowles, Martin Wabitsch, Thomas Quertermous et al. · 2021 · The American Journal of Human Genetics
The Immuno-Modulatory Activities of Pentaherbs Formula on Ovalbumin-Induced Allergic Rhinitis Mice via the Activation of Th1 and Treg Cells and Inhibition of Th2 and Th17 Cells
Peiting Li, Miranda Sin‐Man Tsang, Lea Ling‐Yu Kan, Tianheng Hou, Sharon Sze-Man Hon, Ben Chung-Lap Chan, Ida Miu‐Ting Chu, Christopher Wai-Kei Lam, Ping‐Chung Leung, Chun Kwok Wong · 2021 · Molecules
Genetic architecture of asthma in African American patients
Xiao Chang, Michael March, Frank D. Mentch, Hui‐Qi Qu, Yichuan Liu, Joseph Glessner, Patrick M. Abou‐Sleiman, Hakon H. Hakonarson · 2022 · Journal of Allergy and Clinical Immunology
Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity
Antje Häder, Sascha Schäuble, Jan Gehlen, Nadja Thielemann, Benedikt C. Buerfent, Vitalia Schüller, Timo Hess, Thomas Wolf, Julia Schröder, Michael Weber et al. · 2023 · Nature Communications
Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis
Ravi Ramessur, Jake R. Saklatvala, Ashley Budu‐Aggrey, Marek Ostaszewski, Lena Möbus, Dario Greco, ’Matladi N. Ndlovu, Satveer K. Mahil, Jonathan N. Barker, Sara Brown et al. · 2024 · JAMA Cardiology
Chronic Rhinitis Is a High-Risk Comorbidity for 30-Day Hospital Readmission of Patients with Asthma and Chronic Obstructive Pulmonary Disease
Umesh Pratap Singh, Victoria Wangia-Anderson, Jonathan A. Bernstein · 2018 · The Journal of Allergy and Clinical Immunology In Practice
Epigenetic‐modifying therapies: An emerging avenue for the treatment of inflammatory skin diseases
Julie Z. Yi, Jean S. McGee · 2021 · Experimental Dermatology
RNA-Seq Identifies Marked Th17 Cell Activation and Altered CFTR Expression in Different Atopic Dermatitis Subtypes in Chinese Han Populations
Xin Tian, Baoyi Liu, Lijie Chen, Yongyi Xie, Jingyao Liang, Yan Yang, Lei Shao, Jing Zhang, Jianqin Wang, Xibao Zhang et al. · 2021 · Frontiers in Immunology
An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum
Li, Yang Eric, Preissl, Sebastian, Hou, Xiaomeng, Zhang, Ziyang, Zhang, Kai, Fang, Rongxin, Qiu, Yunjiang, Poirion, Olivier, Li, Bin, Liu, Hanqing et al. · 2020
A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
Marta Riise Moksnes, Ailin Falkmo Hansen, Brooke N. Wolford, Laurent F. Thomas, Humaira Rasheed, Anica Simić, Laxmi Bhatta, Anne Lise Brantsæter, Ida L. Surakka, Wei Zhou et al. · 2024 · Communications Biology
The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: Where do we stand?
Niloufar Farzan, Susanne J. H. Vijverberg, Michael Kabesch, Peter J. Sterk, Anke H. Maitland‐van der Zee · 2018 · Pediatric Pulmonology
Insights into respiratory disease through bioinformatics
Bhavna Hurgobin, Emma de Jong, Anthony Bosco · 2018 · Respirology
EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis
Martina S. Elias, Sheila C. Wright, Judit Reményi, James Abbott, Susan E. Bray, Christian Cole, Sharon Edwards, Marek Gierliński, Mateusz Glok, John Alexander McGrath et al. · 2019 · Journal of Allergy and Clinical Immunology
Update on the genetics of allergic diseases
Lucinda P. Lawson, Sreeja Parameswaran, Ronald Allan M. Panganiban, Gregory M. Constantine, Matthew T. Weirauch, Leah Claire Kottyan · 2025 · Journal of Allergy and Clinical Immunology
Academic achievement of adolescents with asthma or atopic disease
Bronwyn K. Brew, J. Söderberg, Cecilia Lundholm, Soren Afshar, Kirsten Holmberg, Catarina Almqvist · 2019 · Clinical & Experimental Allergy
Pathogenesis of solar urticaria: Classic perspectives and emerging concepts
Sheila Mary McSweeney, Robert Sarkany, Hiva Fassihi, Christos Tziotzios, John Alexander McGrath · 2021 · Experimental Dermatology
MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis
Silu Wen, Fen Li, Yulei Tang, Lin Dong, Yan He, Yuqin Deng, Zezhang Tao · 2023 · Frontiers in Immunology
SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease
Satu J. Strausz, Erik Abner, Grace Blacker, Sarah Galloway, Paige S. Hansen, Qingying Feng, Brandon Hochahn Lee, Samuel E. Jones, Hele Haapaniemi, Sten Raak et al. · 2024 · Nature Communications
Trans-eQTL mapping in gene sets identifies network effects of genetic variants
Lili Wang, Nikita Babushkin, Zhonghua Liu, Xuanyao Liu · 2024 · Cell Genomics
Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases
Jennifer L. Asimit, Daniel B. Rainbow, Mary D Fortune, Nastasiya F. Grinberg, Linda S. Wicker, Chris Wallace · 2019 · Nature Communications
Comparison of individual-level and population-level risk factors for rhinoconjunctivitis, asthma, and eczema in the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three
Charlotte E Rutter, Richard J. Silverwood, M. Innes Asher, Philippa Ellen Ellwood, Neil E. Pearce, Luis García‐Marcos, David Peter Strachan · 2020 · World Allergy Organization Journal
Advancing drug discovery using the power of the human genome
Karl Heilbron, Sahar V. Mozaffari, Vladimir Vacic, Peng Yue, Wei Wang, Jingchunzi Shi, Adrian M. Jubb, Steven J. Pitts, Xin Wang · 2021 · The Journal of Pathology
pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis
Liang Xie, Craig I. McKenzie, Xinyan Qu, Yan Mu, Quanbo Wang, Nan Bing, Karmella Naidoo, Jahangir Alam, Di Yu, Fang Gong et al. · 2021 · The Journal of Immunology
When the allergy alarm bells toll: The role of Toll-like receptors in allergic diseases and treatment
Mario Wenger, Sophie Grosse-Kathoefer, Amin Kraiem, Erica Pelamatti, Natalia Neto dos Santos Nunes, Lisa Pointner, Lorenz Aglas · 2023 · Frontiers in Molecular Biosciences
A paper-based chemiluminescence immunoassay device for rapid and high-throughput detection of allergen-specific IgE
Xisi Han, Mengda Cao, Meirong Wu, Yujie Wang, Changmin Yu, Chengwu Zhang, Haidong Yu, Ji‐Fu Wei, Lin Li, Wei Huang · 2019 · The Analyst
A thymic stromal lymphopoietin polymorphism may provide protection from asthma by altering gene expression
Amy Moorehead, Raphael Hanna, Delia Heroux, Helen Neighbour, Andrew J. Sandford, Gail M. Gauvreau, Doron D. Sommer, Judah A. Denburg, Loubna Akhabir · 2020 · Clinical & Experimental Allergy
The role of DNA methylation in personalized medicine for immune-related diseases
Manoj Kumar Gupta, He Peng, Yang Li, Cheng‐Jian Xu · 2023 · Pharmacology & Therapeutics
Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma
Emma E. Thompson, Quynh N. Dang, Blair Mitchell-Handley, Kavitha Rajendran, Sumati Ram‐Mohan, Julian Solway, Carole Ober, Ramaswamy Krishnan · 2020 · Genome Medicine
New concepts in pediatric rhinitis
Nikolaos G. Papadopoulos, Xenofon Aggelidis, Sofia Stamataki, Emmanuel P. Prokopakis, Michael Katotomichelakis, Paraskevi Vicky Xepapadaki · 2021 · Pediatric Allergy and Immunology
Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children
Matthew C. Altman, Kaitlin J. Flynn, Mario G. Rosasco, Matthew Dapas, Meyer Kattan, Stephanie Lovinsky‐Desir, George T. O’Connor, Michelle Ann Gill, Rebecca S. Gruchalla, Andrew H. Liu et al. · 2021 · Journal of Allergy and Clinical Immunology
Genome-wide admixture and association analysis identifies African ancestry–specific risk loci of eosinophilic esophagitis in African Americans
Yadu Gautam, Julie M. Caldwell, Leah Claire Kottyan, Mirna Chehade, Evan S. Dellon, Marc E. Rothenberg, Tesfaye Mersha Baye, Joshua B. Wechsler, Carla Davis, Glenn T. Furuta et al. · 2022 · Journal of Allergy and Clinical Immunology
Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective
Ravi Ramessur, Nick Dand, Sinéad Langan, Jake R. Saklatvala, Marie-Christine Fritzsche, Suzi Holland, Bernd W. M. Arents, Helen McAteer, Andrew Proctor, David McMahon et al. · 2024 · British Journal of Dermatology