Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 328

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

New common variants affecting susceptibility to basal cell carcinoma

Open access
Stacey, Simon N, Sulem, Patrick, Masson, Gisli, Gudjonsson, Sigurjon A, Thorleifsson, Gudmar, Jakobsdottir, Margret, Sigurdsson, Asgeir, Gudbjartsson, Daniel F, Sigurgeirsson, Bardur, Benediktsdottir, Kristrun R, Thorisdottir, Kristin, Ragnarsson, Rafn, Scherer, Dominique, Hemminki, Kari, Rudnai, Peter, Gurzau, Eugene, Koppova, Kvetoslava, Botella-Estrada, Rafael, Soriano, Virtudes, Juberias, Pablo, Saez, Berta, Gilaberte, Yolanda, Fuentelsaz, Victoria, Corredera, Cristina, Grasa, Matilde, Höiom, Veronica, Lindblom, Annika, Bonenkamp, Johannes J, van Rossum, Michelle M, Aben, Katja K H, de Vries, Esther, Santinami, Mario, Di Mauro, Maria G, Maurichi, Andrea, Wendt, Judith, Hochleitner, Pia, Pehamberger, Hubert, Gudmundsson, Julius, Magnusdottir, Droplaug N, Gretarsdottir, Solveig, Holm, Hilma, Steinthorsdottir, Valgerdur, Frigge, Michael L, Blondal, Thorarinn, Saemundsdottir, Jona, Bjarnason, Hjördis, Kristjansson, Kristleifur, Bjornsdottir, Gyda, Okamoto, Ichiro, Rivoltini, Licia, Rodolfo, Monica, Kiemeney, Lambertus A, Hansson, Johan, Nagore, Eduardo, Mayordomo, José I, Kumar, Rajiv, Karagas, Margaret R, Nelson, Heather H, Gulcher, Jeffrey R, Rafnar, Thorunn, Thorsteinsdottir, Unnur, Olafsson, Jon H, Kong, Augustine, Stefansson, Kari·2009·Nature Genetics
DOI 10.1038/ng.412
Open this paper in CoChat — free account

Abstract

In a follow-up to our previously reported genome-wide association study of cutaneous basal cell carcinoma (BCC), we describe here several new susceptibility variants. SNP rs11170164, encoding a G138E substitution in the keratin 5 (KRT5) gene, affects risk of BCC (OR = 1.35, P = 2.1 × 10−9). A variant at 9p21 near CDKN2A and CDKN2B also confers susceptibility to BCC (rs2151280[C]; OR = 1.19, P = 6.9 × 10−9), as does rs157935[T] at 7q32 near the imprinted gene KLF14 (OR = 1.23, P = 5.7 × 10−10). The effect of rs157935[T] is dependent on the parental origin of the risk allele. None of these variants were found to be associated with melanoma or fair-pigmentation traits. A melanoma- and pigmentation-associated variant in the SLC45A2 gene, L374F, is associated with risk of both BCC and squamous cell carcinoma. Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ng.412

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

See all 328

Metadata

Authors
Stacey, S. N., Sulem, P., Masson, G., Gudjonsson, S. A., Thorleifsson, G., Jakobsdottir, M., Sigurdsson, A., Gudbjartsson, D. F., Sigurgeirsson, B., Benediktsdottir, K. R., Thorisdottir, K., Ragnarsson, R., Scherer, D., Hemminki, K., Rudnai, P., Gurzau, E., Koppova, K., Botella-Estrada, R., Soriano, V., Juberias, P., Saez, B., Gilaberte, Y., Fuentelsaz, V., Corredera, C., Grasa, M., Höiom, V., Lindblom, A., Bonenkamp, J. J., van Rossum, M. M., Aben, K. K. H., de Vries, E., Santinami, M., Di Mauro, M. G., Maurichi, A., Wendt, J., Hochleitner, P., Pehamberger, H., Gudmundsson, J., Magnusdottir, D. N., Gretarsdottir, S., Holm, H., Steinthorsdottir, V., Frigge, M. L., Blondal, T., Saemundsdottir, J., Bjarnason, H., Kristjansson, K., Bjornsdottir, G., Okamoto, I., Rivoltini, L., Rodolfo, M., Kiemeney, L. A., Hansson, J., Nagore, E., Mayordomo, J. I., Kumar, R., Karagas, M. R., Nelson, H. H., Gulcher, J. R., Rafnar, T., Thorsteinsdottir, U., Olafsson, J. H., Kong, A., & Stefansson, K.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2009-07-05
Volume
41
Issue
8
Pages
909-914
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.412
OpenAlex
W2091298691
Cited by
328
References
10
FWCI
25.91
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.