The DOI matches its Crossref record; 461 of the 461 references it cites were found in a registry or an index.
Mammalian Krüppel-Like Factors in Health and Diseases
Open accessAbstract
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological processes that include proliferation, differentiation, growth, development, survival, and responses to external stress. Seventeen mammalian KLFs have been identified, and numerous studies have been published that describe their basic biology and contribution to human diseases. KLF proteins have received much attention because of their involvement in the development and homeostasis of numerous organ systems. KLFs are critical regulators of physiological systems that include the cardiovascular, digestive, respiratory, hematological, and immune systems and are involved in disorders such as obesity, cardiovascular disease, cancer, and inflammatory conditions. Furthermore, KLFs play an important role in reprogramming somatic cells into induced pluripotent stem (iPS) cells and maintaining the pluripotent state of embryonic stem cells. As research on KLF proteins progresses, additional KLF functions and associations with disease are likely to be discovered. Here, we review the current knowledge of KLF proteins and describe common attributes of their biochemical and physiological functions and their pathophysiological roles.
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Self-citationA single-cell atlas of chromatin accessibility in the human genome
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Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization
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Klf15 orchestrates circadian nitrogen homeostasis
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Metadata
- Authors
- McConnell, B. B., & Yang, V. W.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2010-10
- Volume
- 90
- Issue
- 4
- Pages
- 1337-1381
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2041986831
- Cited by
- 1,018
- References
- 461
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
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