The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Germline genomic variants associated with childhood acute lymphoblastic leukemia
Open accessAbstract
Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed significantly(P < 1 × 10−5) between pediatric acute lymphoblastic leukemia (ALL) cases (n = 317) and non-ALL controls (n = 17,958). Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 × 10−15, odds ratio (OR) = 1.91; rs10994982, P = 5.7 × 10−9, OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 × 10−5, OR = 2.17; rs10994982, P = 0.003, OR 1.72). These ARID5B SNPs also distinguished B-hyperdiploid ALL from other subtypes in an independent validation cohort (n = 124 children with ALL; P = 0.003 and P = 0.0008, OR 2.45 and 2.86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.
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Self-citationDeletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia
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New IBD genetics: common pathways with other diseases
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A 50-Year Journey to Cure Childhood Acute Lymphoblastic Leukemia
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Metadata
- Authors
- Treviño, L. R., Yang, W., French, D., Hunger, S. P., Carroll, W. L., Devidas, M., Willman, C., Neale, G., Downing, J., Raimondi, S. C., Pui, C.-H., Evans, W. E., & Relling, M. V.
- Venue
- Nature Genetics
- Published
- 2009-08-16
- Volume
- 41
- Issue
- 9
- Pages
- 1001-1005
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2056176185
- Cited by
- 502
- References
- 41
- FWCI
- 40.14
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
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