New IBD genetics: common pathways with other diseases

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Finding the missing heritability of complex diseases

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works

A map of human genome variation from population-scale sequencing.

The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

A haplotype map of the human genome

The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

Eaden, J., Abrams, K. R., & Mayberry, J. F. (2001) · Gut · doi:10.1136/gut.48.4.526 · Cited by 2,948 · see citing works

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753 · see citing works

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520 · see citing works

Genome-wide association study identifies novel breast cancer susceptibility loci

Easton, D. F., Pooley, K. A., Dunning, A. M., Pharoah, P. D. P., Thompson, D., Ballinger, D. G., Struewing, J. P., Morrison, J., Field, H., Luben, R., et al. (2007) · Nature · doi:10.1038/nature05887 · Cited by 2,319 · see citing works

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works

Genomewide Association Analysis of Coronary Artery Disease

Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044 · see citing works

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,003 · see citing works

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746 · see citing works

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746 · see citing works

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Yamagata, K., Oda, N., Kaisaki, P. J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R., Lathrop, M. G., Boriraj, V. V., et al. (1996) · Nature · doi:10.1038/384455a0 · Cited by 1,610 · see citing works

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D. P., Heath, S. C., Depner, M., Berg, A. V., Bufe, A., Rietschel, E., et al. (2007) · Nature · doi:10.1038/nature06014 · Cited by 1,590 · see citing works

A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501 · see citing works

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Horikawa, Y., Oda, N., Cox, N. J., Li, X., Orho‐Melander, M., Hara, M., Hinokio, Y., Lindner, T. H., Mashima, H., Schwarz, P. E. H., et al. (2000) · Nature Genetics · doi:10.1038/79876 · Cited by 1,467 · see citing works

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452 · see citing works

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J. P., Meloni, T., Lucarelli, P., Pellecchia, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1323 · Cited by 1,419 · see citing works

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411 · see citing works

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374 · see citing works

Common variants at 30 loci contribute to polygenic dyslipidemia

Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364 · see citing works

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D’Amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M. B., Latiano, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.764 · Cited by 1,312 · see citing works

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley, J. B., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Moser, K. L., Tsao, B. P., Vyse, T. J., & Langefeld, C. D. (2008) · Nature Genetics · doi:10.1038/ng.81 · Cited by 1,309 · see citing works

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

Travassos, L. H., Carneiro, L. A. M., Ramjeet, M., Hussey, S., Kim, Y.-G., Magalhães, J. G., Yuan, L., Soares, F., Chea, E., Le Bourhis, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1823 · Cited by 1,306 · see citing works

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

BIRAC Consortium, Stahl, E. A., YEAR Consortium, Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., Li, Y., Kurreeman, F. A. S., et al. (2010) · Nature Genetics · doi:10.1038/ng.582 · Cited by 1,253 · see citing works

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,144 · see citing works

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

Cargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086 · see citing works

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G. B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson, V., Ghosh, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2043 · Cited by 1,072 · see citing works

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

Cooney, R. M., BAKER, J. T., Brain, O., Danis, B., Pichulik, T., Allan, P., Ferguson, D. J. P., Campbell, B. J., Jewell, D. P., & Simmons, A. (2009) · Nature Medicine · doi:10.1038/nm.2069 · Cited by 1,046 · see citing works

Genomewide Association Study of Leprosy

Zhang, F., Huang, W., Chen, S., Sun, L., Liu, H. D., Li, Y., Cui, Y., Yan, X., Yang, H., Yang, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903753 · Cited by 1,037 · see citing works

Multiple common variants for celiac disease influencing immune gene expression

Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G., Ádány, R., Aromaa, A. J., et al. (2010) · Nature Genetics · doi:10.1038/ng.543 · Cited by 1,026 · see citing works

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

Yamagata, K., Furuta, H., Oda, N., Kaisaki, P. J., Menzel, S., Cox, N. J., Fajans, S. S., Signorini, S. G., Stoffel, M., & Bell, G. I. (1996) · Nature · doi:10.1038/384458a0 · Cited by 975 · see citing works

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Han, J., Zheng, H., Cui, Y., Sun, L., Ye, D., Hu, Z. Q., Xu, J., Cai, Z., Huang, W., Zhao, G., et al. (2009) · Nature Genetics · doi:10.1038/ng.472 · Cited by 938 · see citing works

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

MAGIC, Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., et al. (2010) · Nature Genetics · doi:10.1038/ng.685 · Cited by 931 · see citing works

Case 34-1990

Cabot, R. C., Scully, R. E., Mark, E. J., McNeely, W. F., McNeely, B. U., Harris, W. H., & Rosenberg, A. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230808 · Cited by 896 · see citing works

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

Darfeuille–Michaud, A., Neut, C., Barnich, N., Lederman, E., Martino, P. D., Desreumaux, P., Gambiez, L. P., Joly, B., Cortot, A., & Colombel, J.-F. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70019-8 · Cited by 859 · see citing works

Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

Griffiths, C. E. M., Strober, B. E., van de Kerkhof, P., Ho, V., Fidelus-Gort, R., Yeilding, N. M., Guzzo, C. A., Xia, Y., Zhou, B., Li, S., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0810652 · Cited by 857 · see citing works

Anti–Interleukin-12 Antibody for Active Crohn's Disease

Mannon, P., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D. H., Dolin, B. J., Goodman, N., Groden, C. A., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 844 · see citing works

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

Petukhova, L., Duvic, M. A., Hordinsky, M. K., Norris, D. A., Price, V. H., Shimomura, Y., Kim, H., Singh, P., Lee, A., Chen, W. V., et al. (2010) · Nature · doi:10.1038/nature09114 · Cited by 828 · see citing works

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Gateva, V., Sandling, J. K., Hom, G., Taylor, K. E., Chung, S. A., Sun, X., Ortmann, W. A., Kosoy, R., Ferreira, R. C., Nordmark, G., et al. (2009) · Nature Genetics · doi:10.1038/ng.468 · Cited by 810 · see citing works

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800 · see citing works

Genome-wide association study identifies five susceptibility loci for glioma

Shete, S. S., Hosking, F. J., Robertson, L. B., Dobbins, S. E., Sanson, M., Malmer, B., Simon, M., Marie, Y., Boisselier, B., Delattre, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.407 · Cited by 777 · see citing works

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

Sandborn, W. J., Feagan, B. G., Fedorak, R. N., Scherl, E., Fleisher, M. R., Katz, S., Johanns, J., BLANK, M. A., & Rutgeerts, P. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.014 · Cited by 753 · see citing works

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

Smyth, D. J., Plagnol, V., Walker, N. M., Cooper, J. D., Downes, K., Yang, J. H. M., Howson, J. M. M., Stevens, H. E., McManus, R., Wijmenga, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807917 · Cited by 738 · see citing works

Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study

Grainge, M. J., West, J., & Card, T. R. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61963-2 · Cited by 729 · see citing works

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

Sabatti, C., Service, S. K., Hartikainen, A., Pouta, A. M., Ripatti, S., Brodsky, J. F., Jones, C. G., Zaitlen, N., Varilo, T., Kaakinen, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.271 · Cited by 721 · see citing works

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

Heazlewood, C. K., Cook, M. C., Eri, R., Price, G. R., Tauro, S. B., Taupin, D., Thornton, D. J., Png, C. W., Crockford, T. L., Cornall, R. J., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050054 · Cited by 701 · see citing works

Genome-wide association study identifies five new breast cancer susceptibility loci

The Breast Cancer Susceptibility Collaboration (UK), Turnbull, C., Ahmed, S., Morrison, J., Pernet, D., Renwick, A., Maranian, M., Seal, S., Ghoussaini, M., Hines, S., et al. (2010) · Nature Genetics · doi:10.1038/ng.586 · Cited by 687 · see citing works

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

Remmers, E. F., Coşan, F., Kirino, Y., Ombrello, M. J., Abacı, N., Satorius, C. L., Le, J. M., Yang, B. C., Korman, B. D., Çakiris, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.625 · Cited by 678 · see citing works

Newly identified genetic risk variants for celiac disease related to the immune response

Hunt, K. A., Zhernakova, A., Turner, G., Heap, G., Franke, L., Bruinenberg, M., Romanos, J., Dinesen, L. C., Ryan, A. W., Panesar, D., et al. (2008) · Nature Genetics · doi:10.1038/ng.102 · Cited by 675 · see citing works

Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE

Kyogoku, C., Ortmann, W. A., Lee, A., Selby, S. A., Carlton, V. E. H., Chang, M., Ramos, P. S., Baechler, E. C., Batliwalla, F., Novitzke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/423790 · Cited by 671 · see citing works

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

Reveille, J. D., Jin, R., Zhou, X., Diekman, L., Sims, A. M., Danoy, P., Leo, P., Bradbury, L. A., Doan, T., Dowling, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.513 · Cited by 669 · see citing works

Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease

Brand, S. (2009) · Gut · doi:10.1136/gut.2008.163667 · Cited by 664 · see citing works

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

Liu, Y., Helms, C. A., Liao, W. J., Zaba, L. C., Duan, S., Gardner, J. M., Wise, C. A., Miner, A. G., Malloy, M. J., Pullinger, C. R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000041 · Cited by 660 · see citing works

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

McGovern, D. P. B., Gardet, A., Törkvist, L., Goyette, P., Essers, J. B., Taylor, K. D., Neale, B. M., Ong, R. T., Lagacé, C., Li, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.549 · Cited by 654 · see citing works

A genome-wide perspective of genetic variation in human metabolism

Illig, T., Gieger, C., Zhai, G., Römisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmüller, G., Kato, B. S., Mewes, H.-W., et al. (2010) · Nature Genetics · doi:10.1038/ng.507 · Cited by 653 · see citing works

Multiple Genetic Loci for Bone Mineral Density and Fractures

Styrkársdóttir, U., Halldórsson, B. V., Grétarsdóttir, S., Gudbjartsson, D. F., Walters, G. B., Ingvarsson, Þ., Jónsdóttir, Þ., Saemundsdottir, J., Nguyen, T. V., Bagger, Y. Z., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801197 · Cited by 629 · see citing works

Roles of Fc receptors in autoimmunity

Takai, T. (2002) · Nature reviews. Immunology · doi:10.1038/nri856 · Cited by 627 · see citing works

The molecular classification of the clinical manifestations of Crohn's disease

Ahmad, T., Armuzzi, A., Bunce, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32413 · Cited by 622 · see citing works

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

Barrett, J., Lee, J. C., Lees, C., Prescott, N., Anderson, C., Phillips, A., Wesley, E., Parnell, K. S., Zhang, H., Drummond, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.483 · Cited by 602 · see citing works

The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study.

Bernstein, C., Wajda, A., & Blanchard, J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.021 · Cited by 599 · see citing works

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

the IBSEN study group, Franke, A., Balschun, T. C., Karlsen, T. H., Skiecevičienė, J., Nikolaus, S., Gabriele Mayr, B., Domingues, F. S., Albrecht, M., Nothnagel, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.221 · Cited by 590 · see citing works

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

Libioulle, C., Louis, E. J., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D. P., Vermeire, S., Dewit, O., Vos, M. D., Dixon, A., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030058 · Cited by 561 · see citing works

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

Study, C. (2008) · Nature Genetics · doi:10.1038/ng.262 · Cited by 558 · see citing works

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551 · see citing works

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · see citing works

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ

Rousseaux, C., Lefebvre, B., Dubuquoy, L., Lefèbvre, P., Romano, O., Auwerx, J. H., METZGER, D., Wahli, W., Desvergne, B., Naccari, G. C., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041948 · Cited by 528 · see citing works

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

Mizuki, N., Meguro, A., Ôta, M., Ohno, S., Shiota, T., Kawagoe, T., Ito, N., Kera, J., Okada, E., Yatsu, K., et al. (2010) · Nature Genetics · doi:10.1038/ng.624 · Cited by 525 · see citing works

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Soranzo, N., Spector, T. D., Mangino, M., Kuehnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B. J., Chen, L., Li, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.467 · Cited by 520 · see citing works

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

Nakamura, T., Furuhashi, M., Li, P., Cao, H., Tuncman, G., Sonenberg, N., Görgün, C. Z., & Hotamışlıgil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.01.001 · Cited by 498 · see citing works

Germline genomic variants associated with childhood acute lymphoblastic leukemia

Treviño, L. R., Yang, W., French, D., Hunger, S. P., Carroll, W. L., Devidas, M., Willman, C. L., Neale, G. A. M., Downing, J. R., Raimondi, S. C., et al. (2009) · Nature Genetics · doi:10.1038/ng.432 · Cited by 497 · see citing works

Sarcoidosis is associated with a truncating splice site mutation in BTNL2

Valentonyte, R., Hampe, J., Huse, K., Rosenstiel, P. C., Albrecht, M., Stenzel, A., Nagy, M., Gaede, K. I., Franke, A., Häsler, R., et al. (2005) · Nature Genetics · doi:10.1038/ng1519 · Cited by 487 · see citing works

Lack of common NOD2 variants in Japanese patients with Crohn's disease

Inoue, N., Tamura, K., Kinouchi, Y., Fukuda, Y., Takahashi, S., Ogura, Y., Inohara, N., Núñez, G., Kishi, Y., Koike, Y., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34155 · Cited by 483 · see citing works

Common variants at five new loci associated with early-onset inflammatory bowel disease

Imielinski, M. B., Baldassano, R. N., Griffiths, A. M., Russell, R. K., Annese, V., Dubinsky, M. C., Kugathasan, S., Bradfield, J. P., Walters, T. D., Abou‐Sleiman, P. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.489 · Cited by 479 · see citing works

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

Papaemmanuil, E., Hosking, F. J., Vijayakrishnan, J., Price, A., Olver, B. D., Sheridan, E., Kinsey, S. E., Lightfoot, T. J., Roman, E., Irving, J. A. E., et al. (2009) · Nature Genetics · doi:10.1038/ng.430 · Cited by 477 · see citing works

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

Yamazaki, K., McGovern, D. P. B., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D. P., Cardon, L. R., Takazoe, M., Tanaka, T., Ichimori, T., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi379 · Cited by 468 · see citing works

Prevalence of Primary Sclerosing Cholangitis in Patients With Ulcerative Colitis

Olsson, R., Danielsson, Å., Järnerot, G., Lindström, E., Lööf, L., Rolny, P., Rydén, B.-O., Tysk, C., & Wallerstedt, S. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)70019-t · Cited by 424 · see citing works

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Fisher, S. A., Tremelling, M., Anderson, C. A., Gwilliam, R., Bumpstead, S., Prescott, N. J., Nimmo, E. R., Massey, D. C. O., Berzuini, C., Johnson, C., et al. (2008) · Nature Genetics · doi:10.1038/ng.145 · Cited by 424 · see citing works

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Eeles, R. A., Collaborators, T. U. P. S., Kote‐Jarai, Z., Olama, A. A. A., Giles, G. G., Guy, M., Severi, G., Muir, K. R., Hopper, J. L., Henderson, B. E., et al. (2009) · Nature Genetics · doi:10.1038/ng.450 · Cited by 418 · see citing works

Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo

Jin, Y., Birlea, S. A., Fain, P. R., Gowan, K., Riccardi, S. L., Holland, P. J., Mailloux, C. M., Sufit, A., Hutton, S. M., Amadi‐Myers, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908547 · Cited by 415 · see citing works

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., Macciardi, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.627 · Cited by 398 · see citing works

Defective acute inflammation in Crohn's disease: a clinical investigation

Marks, D. J., Harbord, M., MacAllister, R. J., Rahman, F. Z., Young, J., Al‐Lazikani, B., Lees, W. R., Novelli, M. R., Bloom, S. L., & Segal, A. W. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68265-2 · Cited by 384 · see citing works

Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

Karlsen, T. H., Franke, A., Melum, E., Kaser, A., Hov, J. R., Balschun, T. C., Lie, B. A., Bergquist, A. M., Schramm, C., Weismüller, T. J., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.046 · Cited by 360 · see citing works

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

Raychaudhuri, S., Thomson, B. P., Remmers, E. F., Eyre, S., Hinks, A., Guiducci, C., Catanese, J. J., ., G. X., Stahl, E. A., Chen, R., et al. (2009) · Nature Genetics · doi:10.1038/ng.479 · Cited by 351 · see citing works

A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms

Kilpivaara, O., Mukherjee, S., Schram, A. M., Wadleigh, M., Mullally, A., Ebert, B. L., Bass, A. J., Marubayashi, S., Heguy, A., Garcia‐Manero, G., et al. (2009) · Nature Genetics · doi:10.1038/ng.342 · Cited by 349 · see citing works

Recent Advances in the Genetics of Autoimmune Disease

Gregersen, P. K., & Olsson, L. M. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 337 · see citing works

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

Gregersen, P. K., Amos, C. I., Lee, A. T., Lu, Y., Remmers, E. F., Kastner, D. L., Seldin, M. F., Criswell, L. A., Plenge, R. M., Holers, V. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.395 · Cited by 331 · see citing works

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

Wallace, C., Smyth, D. J., Maisuria-Armer, M., Walker, N. M., Todd, J. A., & Clayton, D. G. (2009) · Nature Genetics · doi:10.1038/ng.493 · Cited by 325 · see citing works

Variants of DENND1B Associated with Asthma in Children

Abou‐Sleiman, P. M., Flory, J. H., Imielinski, M. B., Bradfield, J. P., Annaiah, K., Willis‐Owen, S. A. G., Wang, K., Rafaels, N. M., Michel, S., Bønnelykke, K., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901867 · Cited by 321 · see citing works

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

Kugathasan, S., Baldassano, R. N., Bradfield, J. P., Abou‐Sleiman, P. M., Imielinski, M. B., Guthery, S. L., Cucchiara, S., Kim, C. E., Frackelton, E. C., Annaiah, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.203 · Cited by 318 · see citing works

A common variant on chromosome 11q13 is associated with atopic dermatitis

Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.347 · Cited by 317 · see citing works

Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly

Lapaquette, P., Glasser, A.-L., Huett, A. S., Xavier, R. J., & Darfeuille–Michaud, A. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01381.x · Cited by 312 · see citing works

Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis

Mahdi, H., Fisher, B. A., Källberg, H., Plant, D., Malmström, V., Rönnelid, J., Charles, P. J., Ding, B., Alfredsson, L. S., Padyukov, L., et al. (2009) · Nature Genetics · doi:10.1038/ng.480 · Cited by 309 · see citing works

Genetics of Crohn disease, an archetypal inflammatory barrier disease

Schreiber, S., Rosenstiel, P. C., Albrecht, M., Hampe, J., & Krawczak, M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1607 · Cited by 306 · see citing works

Interleukin-10 Blocked Endoplasmic Reticulum Stress in Intestinal Epithelial Cells: Impact on Chronic Inflammation

Shkoda, A., Ruiz, P. A., Daniel, H., Kim, S. C., Rogler, G., Sartor, R. B., & Haller, D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.030 · Cited by 278 · see citing works

Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis

Nair, R. P., Ruether, A., Stuart, P. E., Jenisch, S., Tejasvi, T., Hiremagalore, R., Schreiber, S., Kabelitz, D., Lim, H. W., Voorhees, J. J., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701255 · Cited by 277 · see citing works

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population

Asano, K., Matsushita, T., Umeno, J., Hosono, N., Takahashi, A., Kawaguchi, T., Matsumoto, T., Matsui, T., Kakuta, Y., Kinouchi, Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.482 · Cited by 276 · see citing works

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

Cantero-Recasens, G., Fandos, C., Rubio-Moscardó, F., Valverde, M. A., & Vicente, R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp471 · Cited by 269 · see citing works

Increased Risk for Demyelinating Diseases in Patients With Inflammatory Bowel Disease

Gupta, G., Gelfand, J. M., & Lewis, J. D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.022 · Cited by 266 · see citing works

Thoracic Manifestations of Inflammatory Bowel Disease

Black, H. R., Mendoza, M. D., & Murin, S. (2007) · CHEST Journal · doi:10.1378/chest.06-1074 · Cited by 266 · see citing works

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

Kochi, Y., Okada, Y., Suzuki, A., Ikari, K., Terao, C. C., Takahashi, A., Yamazaki, K., Hosono, N., Myouzen, K., Tsunoda, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.583 · Cited by 264 · see citing works

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

International MHC and Autoimmunity Genetics Network (IMAGEN)*, Rioux, J. D., Goyette, P., Vyse, T. J., Hammarström, L. L. G., Fernando, M. M. A., Green, T. J., Jager, P. L. D., Foisy, S., Wang, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909307106 · Cited by 256 · see citing works

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

Clayton, D. G. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000540 · Cited by 252 · see citing works

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

Jakkula, E., Leppä, V., Sulonen, A.-M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.-L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.01.017 · Cited by 245 · see citing works

The Incidence of Arterial Thromboembolic Diseases in Inflammatory Bowel Disease: A Population-Based Study

Bernstein, C. N., Wajda, A., & Blanchard, J. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.09.016 · Cited by 241 · see citing works

Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease

Ha, C. Y., Magowan, S., Accortt, N., Chen, J., & Stone, C. (2009) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.81 · Cited by 231 · see citing works

Rosiglitazone for Active Ulcerative Colitis: A Randomized Placebo-Controlled Trial

Lewis, J. D., Lichtenstein, G. R., Deren, J. J., Sands, B. E., Hanauer, S. B., Katz, J. A., Lashner, B. A., Present, D. H., Chuai, S., Ellenberg, J. H., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.012 · Cited by 229 · see citing works

Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains

Intemann, C. D., Thye, T., Niemann, S., Browne, E. N. L., Chinbuah, M. A., Enimil, A. K., Gyapong, J. O., Osei, I., Owusu‐Dabo, E., Helm, S., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000577 · Cited by 226 · see citing works

NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population

Leong, R. W. L., Armuzzi, A., Ahmad, T., Wong, M. L., Tse, P., Jewell, D. P., & Sung, J. J. �. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01607.x · Cited by 226 · see citing works

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

Zhao, F. R., Edwards, R. A., Dizon, D., Afrasiabi, K., Mastroianni, J. R., Geyfman, M., Ouellette, A. J., D, B. A. M., & Lipkin, S. M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.008 · Cited by 219 · see citing works

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

Hirschfield, G. M., Liu, X., Han, Y., Gorlov, I. P., Lu, Y., Xu, C., Lu, Y., Chen, W., Juran, B. D., Coltescu, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.631 · Cited by 215 · see citing works

Novel Association in Chromosome 4q27 Region with Rheumatoid Arthritis and Confirmation of Type 1 Diabetes Point to a General Risk Locus for Autoimmune Diseases

Zhernakova, A., Alizadeh, B. Z., Bevova, M. R., Leeuwen, M. A. V., Coenen, M. J. H., Franke, B., Franke, L., Posthumus, M. D., van Heel, D. A., van der Steege, G., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/522037 · Cited by 213 · see citing works

Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC

Quan, C., Ren, Y., Xiang, L. F., Sun, L., Xu, A., Gao, X.-H., Chen, H., Pu, X.-M., Wu, R.-N., Liang, C.-Z., et al. (2010) · Nature Genetics · doi:10.1038/ng.603 · Cited by 213 · see citing works

Skewed distribution of IGG FC receptor iia (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients

Duits, A. J., Bootsma, H., Derksen, R. H. W. M., Spronk, P. E., Kater, L., Kallenberg, C. G. M., Capel, P. J., WESTERDAAL, N. A. C., Spierenburg, G. T., Gmelig-Meyling, F. H. J., et al. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780381217 · Cited by 211 · see citing works

Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study).

Palm, Ø., Moum, B. A., Ongre, A. A., et al. (2002) · PubMed · Cited by 207 · see citing works

Further evidence for an association between psoriasis, Crohn's disease and ulcerative colitis

YATES, V. M., Watkinson, G., & Kelman, A. W. (1982) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1982.tb01731.x · Cited by 194 · see citing works

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

and the IBSEN study group, Franke, A., Balschun, T. C., Sina, C., Ellinghaus, D., Häsler, R., Gabriele Mayr, B., Albrecht, M., Wittig, M., Buchert, E., et al. (2010) · Nature Genetics · doi:10.1038/ng.553 · Cited by 194 · see citing works

Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

Anderson, C. A., Massey, D. C. O., Barrett, J. C., Prescott, N. J., Tremelling, M., Fisher, S. A., Gwilliam, R., Jacob, J., Nimmo, E. R., Drummond, H. E., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.032 · Cited by 183 · see citing works

Disease Activity, ANCA, and IL23R Genotype Status Determine Early Response to Infliximab in Patients With Ulcerative Colitis

Jürgens, M., Laubender, R. P., Hartl, F., Weidinger, M., Seiderer, J., Wagner, J. E., Wetzke, M., Beigel, F., Pfennig, S., Stallhofer, J., et al. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.95 · Cited by 169 · see citing works

Genetics of ulcerative colitis

Thompson, A., & Lees, C. W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21375 · Cited by 166 · see citing works

The genetics of autoimmune diseases: a networked perspective

Baranzini, S. E. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.09.014 · Cited by 161 · see citing works

Polymorphisms in E-cadherin ( CDH1 ) result in a mis-localised cytoplasmic protein that is associated with Crohn’s disease

Muise, A. M., Walters, T. D., Glowacka, W. K., Griffiths, A. M., Ngan, B., Lan, H., Xu, W., Silverberg, M. S., & Rotin, D. (2009) · Gut · doi:10.1136/gut.2008.175117 · Cited by 153 · see citing works

Familial association between type 1 diabetes and other autoimmune and related diseases

Hemminki, K., Li, X., Sundquist, J., & Sundquist, K. (2009) · Diabetologia · doi:10.1007/s00125-009-1427-3 · Cited by 147 · see citing works

Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease

Picco, M. F. (2009) · Yearbook of Gastroenterology · doi:10.1016/s0739-5930(09)79360-2 · Cited by 147 · see citing works

Autoimmune disease concomitance among inflammatory bowel disease patients in the United States, 2001-2002

Cohen, R. D., Robinson, D., Paramore, C., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20406 · Cited by 146 · see citing works

Clustering of Inflammatory Bowel Disease With Immune Mediated Diseases Among Members of a Northern California-Managed Care Organization

Weng, X., Liu, L., Barcellos, L. F., Allison, J. E., & Herrinton, L. J. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01215.x · Cited by 141 · see citing works

IBD: a family affair

Russell, R. K., & Satsangi, J. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.12.006 · Cited by 140 · see citing works

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

Festen, E. A. M., Goyette, P., Scott, R. J., Annese, V., Zhernakova, A., Lian, J., Lefèbvre, C., Brant, S. R., Cho, J. H., Silverberg, M. S., et al. (2009) · Gut · doi:10.1136/gut.2008.166918 · Cited by 137 · see citing works

Genome wide association (GWA) predictors of anti-TNFα therapeutic responsiveness in pediatric inflammatory bowel disease

Dubinsky, M. C., Mei, L., Friedman, M., Dhere, T., Haritunians, T., Hakonarson, H. H., Kim, C., Glessner, J., Targan, S. R., McGovern, D. P. B., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21174 · Cited by 136 · see citing works

Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease

Zheng, W., Rosenstiel, P. C., Huse, K., Sina, C., Valentonyte, R., Mah, N., Zeitlmann, L., Grosse, J., Ruf, N., Nürnberg, P., et al. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364263 · Cited by 127 · see citing works

Recent advances in the genetics of rheumatoid arthritis

Raychaudhuri, S. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328336474d · Cited by 126 · see citing works

Inflammatory Bowel Disease in Patients with Celiac Disease

Yang, A., Chen, Y., Scherl, E., Neugut, A. I., Bhagat, G., & Green, P. H. R. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000161308.65951.db · Cited by 126 · see citing works

Diseases associated with ulcerative colitis and Crohn's disease.

Hammer, B., Ashurst, P. M., & Naish, J. (1968) · Gut · doi:10.1136/gut.9.1.17 · Cited by 124 · see citing works

Common variants in FOXP1 are associated with generalized vitiligo

Jin, Y., Birlea, S. A., Fain, P. R., Mailloux, C. M., Riccardi, S. L., Gowan, K., Holland, P. J., Bennett, D. C., Wallace, M. R., McCormack, W. T., et al. (2010) · Nature Genetics · doi:10.1038/ng.602 · Cited by 104 · see citing works

Review article: anti TNF‐α induced psoriasis in patients with inflammatory bowel disease

Fiorino, G., Allez, M., Malesci, A., et al. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03955.x · Cited by 100 · see citing works

Paradoxical adverse events of anti-tumour necrosis factor therapy for spondyloarthropathies: a retrospective study

Fouache, D., Goëb, V., Massy‐Guillemant, N., et al. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep083 · Cited by 100 · see citing works

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

Lees, C. W., & Satsangi, J. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.45 · Cited by 94 · see citing works

Genome-Wide Association Analysis in Sarcoidosis and Crohn's Disease Unravels a Common Susceptibility Locus on 10p12.2

Franke, A., Fischer, A., Nothnagel, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.017 · Cited by 91 · see citing works

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes

Barton, A. C., Eyre, S., Ke, X., Hinks, A., Bowes, J., Flynn, E., Martin, P., Wilson, A. G., Morgan, A. W., Emery, P., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp177 · Cited by 87 · see citing works

Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study

Casella, G., Renata D'Incà, Oliva, L., et al. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.08.005 · Cited by 83 · see citing works

Prevalence of inflammatory bowel disease in patients with airways disease

Raj, A. A., Birring, S. S., Green, R., et al. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2007.08.014 · Cited by 79 · see citing works

Sacro-iliitis and Ulcerative Colitis

Wright, V. A., & Watkinson, G. (1965) · BMJ · doi:10.1136/bmj.2.5463.675 · Cited by 77 · see citing works

Genetics of ankylosing spondylitis

Brown, M. A. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283364483 · Cited by 77 · see citing works

Increased insulin resistance and β cell activity in patients with Crohnʼs disease

Bregenzer, N., Hartmann, A., Strauch, U., Schölmerich, J., Andus, T., & Bollheimer, C. L. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195975.97673.f5 · Cited by 66 · see citing works

Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes

Quaranta, M., Burden, A. D., Griffiths, C. E. M., Worthington, J., Barker, J. N., Trembath, R. C., & Capon, F. (2009) · Genes and Immunity · doi:10.1038/gene.2009.51 · Cited by 65 · see citing works

Chronic Inflammatory Bowel Disease in Patients with Coeliac Disease

Gillberg, R., Dotevall, G., & Åhrén, C. (1982) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528209182237 · Cited by 57 · see citing works

Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis

Alizadeh, B. Z., Valdigem, G., Coenen, M. J. H., Zhernakova, A., Franke, B., Monsuur, A. J., van Riel, P. L. C. M., Barrera, P., Radstake, T. R. D. J., Roep, B. O., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm194 · Cited by 51 · see citing works

Atopic disease in ulcerative colitis and Crohn's disease

PUGH, S. M., Rhodes, J., Mayberry, J. F., Roberts, D. L., Heatley, R. V., & Newcombe, R. G. (1979) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1979.tb01545.x · Cited by 49 · see citing works

Autophagy: from basic science to clinical application

van Limbergen, J., Stevens, C., Nimmo, E., Wilson, D., & Satsangi, J. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.20 · Cited by 45 · see citing works

Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease

Cottone, M., Marrone, C., Casà, A., et al. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200309000-00006 · Cited by 38 · see citing works

Systemic lupus erythematosus and inflammatory bowel disease

Nitzan, O., Elias, M. S., & Saliba, W. (2006) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2006.02.001 · Cited by 35 · see citing works

Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease

Limbergen, J. V., Russell, R. K., Nimmo, E. R., Zhao, Y., Liao, H., Drummond, H. E., Davies, G., Gillett, P. M., McGrogan, P., Bisset, W. M., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20926 · Cited by 28 · see citing works

FAMILIAL ASSOCIATION OF CROHN'S AND COELIAC DISEASES

Cottone, M., Cappello, M., Puleo, A., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90527-8 · Cited by 27 · see citing works

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Heid, I. M., Jackson, A., Randall, J. C., et al. (2011) · Nature Genetics · doi:10.1038/ng1111-1164a · Cited by 25 · see citing works

Pravastatin-induced colitis

Mukhopadhya, A., Gilmour, H., & Plevris, J. N. (2008) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3282f45740 · Cited by 14 · see citing works

Associated ulcerative colitis, sclerosing cholangitis, and insulin-dependent diabetes mellitus

Kay, M., Wyllie, R., Michener, W., et al. (1993) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.60.6.473 · Cited by 7 · see citing works

HLA‐DR3, DQ2 homozygosity in two patients with insulin‐dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis

Ivarsson, S. A., Eriksson, S., Kockum, I. S., et al. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00988.x · Cited by 5 · see citing works

Case 14-2001

Haynes, H. A., Graeme‐Cook, F., & Lerner, L. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441908 · Cited by 5 · see citing works

The gut microbiota in IBD

Manichanh, C., Borruel, N., Casellas, F., & Guarner, F. (2012) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2012.152 · Cited by 1,160 · see citing works

Genetic determinants of the gut microbiome in UK twins

Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works

The gut microbiota and inflammatory bowel disease

Matsuoka, K., & Kanai, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0454-4 · Cited by 804 · see citing works

Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H., & Nicholson, J. K. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.05.006 · Cited by 541 · see citing works

The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin

Weaver, C. T., Elson, C. O., Fouser, L. A., & Kolls, J. K. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130318 · Cited by 462 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

Lee, J. C., Lyons, P. A., McKinney, E. F., Sowerby, J. M., Carr, E. J., Bredin, F., Rickman, H. M., Ratlamwala, H., Hatton, A., Rayner, T. F., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59255 · Cited by 304 · see citing works

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

He, X., Fuller, C. K., Song, Y., Meng, Q., Zhang, B., Yang, X., & Li, H. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.03.022 · Cited by 241 · see citing works

Probiotics in the Management of Inflammatory Bowel Disease: A Systematic Review of Intervention Studies in Adult Patients

Jonkers, D., Penders, J., Masclee, A., & Pierik, M. (2012) · Drugs · doi:10.2165/11632710-000000000-00000 · Cited by 240 · see citing works

Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Huang, E. Y., Inoue, T., Leone, V. A., Dalal, S., Touw, K., Wang, Y., Musch, M. W., Theriault, B., Higuchi, K., Donovan, S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000332 · Cited by 204 · see citing works

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

Kabat, A. M., Harrison, O. J., Riffelmacher, T., Moghaddam, A. E., Pearson, C. F., Laing, A., Abeler-Dörner, L., Forman, S. P., Grencis, R. K., Sattentau, Q., et al. (2016) · eLife · doi:10.7554/elife.12444 · Cited by 193 · see citing works

Big data in IBD: a look into the future

Olivera, P., Danese, S., Jay, N., Natoli, G., & Peyrin-Biroulet, L. (2019) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-019-0102-5 · Cited by 151 · see citing works

REV-ERBα Regulates TH17 Cell Development and Autoimmunity

Amir, M., Chaudhari, S., Wang, R., Campbell, S., Mosure, S. A., Chopp, L. B., Lu, Q., Shang, J., Pelletier, O. B., He, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.101 · Cited by 117 · see citing works

Demography, baseline disease characteristics and treatment history of patients with psoriasis enrolled in a multicentre, prospective, disease‐based registry (PSOLAR)

Kimball, A. B., Leonardi, C., Stahle, M., Gulliver, W., Chevrier, M., Fakharzadeh, S., Goyal, K., Calabro, S., Langholff, W., Menter, A., et al. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13013 · Cited by 117 · see citing works

Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation

Nunez, S. G., Rabelo, S. P., Subotic, N., Caruso, J. W., & Knezevic, N. N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209994 · Cited by 138 · see citing works

Resolution of inflammation in inflammatory bowel disease

Rogler, G. (2017) · The Lancet Gastroenterology &amp; Hepatology · doi:10.1016/s2468-1253(17)30031-6 · Cited by 79 · see citing works

NOD2 is dispensable for ATG16L1 deficiency-mediated resistance to urinary tract infection

Wang, C., Yuan, X., Ma, E., Mendonsa, G. R., Plantinga, T. S., Kiemeney, L. A. L. M., Vermeulen, S. H. H. M., & Mysorekar, I. U. (2013) · Autophagy · doi:10.4161/auto.27196 · Cited by 17 · see citing works

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation

Plantinga, T. S., Joosten, L. A. B., & Netea, M. G. (2011) · Autophagy · doi:10.4161/auto.7.9.15867 · Cited by 27 · see citing works

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

Travassos, L. H., Carneiro, L. A. M., Ramjeet, M., Hussey, S., Kim, Y.-G., Magalhães, J. G., Yuan, L., Soares, F., Chea, E., Le Bourhis, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1823 · Cited by 1,306 · see citing works

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

Sorbara, M. T., Ellison, L. K., Ramjeet, M., Travassos, L. H., Jones, N. L., Girardin, S. E., & Philpott, D. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.001 · Cited by 6 · see citing works

W1239 ATG16L1 and NOD2 Interact in an Autophagy-Dependent Anti-Bacterial Pathway Implicated in Crohn's Disease Pathogenesis

Homer, C. R., Richmond, A. L., Rebert, N. A., et al. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)63131-9 · Cited by 3 · see citing works