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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
Open accessAbstract
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 × 10−11, per-allele odds ratio (OR) 1.26, 95% CI 1.18–1.35) and rs9564966 (P = 5.86 × 10−8, per-allele OR 1.21, 95% CI 1.13–1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 × 10−10, per-allele OR 0.77, 95% CI 0.71–0.84). A single SNP, rs401681 (P = 3.66 × 10−7, per-allele OR 1.19, 95% CI 1.11–1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.
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Metadata
- Authors
- Petersen, G. M., Amundadottir, L., Fuchs, C. S., Kraft, P., Stolzenberg-Solomon, R. Z., Jacobs, K. B., Arslan, A. A., Bueno-de-Mesquita, H. B., Gallinger, S., Gross, M., Helzlsouer, K., Holly, E. A., Jacobs, E. J., Klein, A. P., LaCroix, A., Li, D., Mandelson, M. T., Olson, S. H., Risch, H. A., Zheng, W., Albanes, D., Bamlet, W. R., Berg, C. D., Boutron-Ruault, M.-C., Buring, J. E., Bracci, P. M., Canzian, F., Clipp, S., Cotterchio, M., de Andrade, M., Duell, E. J., Gaziano, J. M., Giovannucci, E. L., Goggins, M., Hallmans, G., Hankinson, S. E., Hassan, M., Howard, B., Hunter, D. J., Hutchinson, A., Jenab, M., Kaaks, R., Kooperberg, C., Krogh, V., Kurtz, R. C., Lynch, S. M., McWilliams, R. R., Mendelsohn, J. B., Michaud, D. S., Parikh, H., Patel, A. V., Peeters, P. H. M., Rajkovic, A., Riboli, E., Rodriguez, L., Seminara, D., Shu, X.-O., Thomas, G., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Van Den Eeden, S. K., Virtamo, J., Wactawski-Wende, J., Wang, Z., Wolpin, B. M., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Fraumeni, J. F., Hoover, R. N., Hartge, P., & Chanock, S. J.
- Venue
- Nature Genetics
- Published
- 2010-01-24
- Volume
- 42
- Issue
- 3
- Pages
- 224-228
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2102413929
- Cited by
- 596
- References
- 14
- FWCI
- 24.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Petersen, G. M., Amundadottir, L., Fuchs, C. S., Kraft, P., Stolzenberg-Solomon, R. Z., Jacobs, K. B., Arslan, A. A., Bueno-de-Mesquita, H. B., Gallinger, S., Gross, M., Helzlsouer, K., Holly, E. A., Jacobs, E. J., Klein, A. P., LaCroix, A., Li, D., Mandelson, M. T., Olson, S. H., Risch, H. A., . . . Chanock, S. J. (2010). A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nature Genetics. https://doi.org/10.1038/ng.522
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