Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

Noble, Suzanne M, French, Sarah, Kohn, Lisa A, Chen, Victoria, Johnson, Alexander D·2010·Nature Genetics

Cited by (679)

Items 601–679 of 679

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  2. The Candida albicans Hsp90 Chaperone Network Is Environmentally Flexible and Evolutionarily Divergent
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  6. Correction: Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis
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  8. The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target
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  15. Phenotypic characterisation of Candida albicans mutants with deletions of arachidonic acid responsive genes
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  21. Regulation of Fungal Drug Resistance and Morphogenesis by Lysine Deacetylases
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    Katura Metzner, Matthew J. O’Meara, Benjamin S. Halligan, Jesse W. Wotring, Jonathan Z. Sexton, Teresa R. O’Meara · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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  60. Additional file 3 of Loss of glucosylceramide synthase impairs the growth and virulence of Fusarium oxysporum f. sp. cubense
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  65. Additional file 1 of Loss of glucosylceramide synthase impairs the growth and virulence of Fusarium oxysporum f. sp. cubense
    Wang, Jian, Zhang, Kun, Huang, Li-Qun, Bao, He-Nan, Na Hai, Yang, Yu-Bing, Siwen Liu, Li, Chun-Yu, Yao, Nan · 2022 · Figshare
  66. Additional file 2 of Loss of glucosylceramide synthase impairs the growth and virulence of Fusarium oxysporum f. sp. cubense
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