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Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Open accessAbstract
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissection of virulence mechanisms. Published analyses of such mutants show a near-perfect correlation between C. albicans pathogenicity and the ability to undergo a yeast-to-hypha morphological switch in vitro. However, most studies have used mutants constructed with a marker that is itself a virulence determinant and therefore complicates their interpretation. Using alternative markers, we created approximately 3,000 homozygous deletion strains affecting 674 genes, or roughly 11% of the C. albicans genome. Screening for infectivity in a mouse model and for morphological switching and cell proliferation in vitro, we identified 115 infectivity-attenuated mutants, of which nearly half demonstrated normal morphological switching and proliferation. Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence.
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“It has been reported that among 674 C. albicans gene-deleted mutants, 59% of these growth-defective mutants were competent for virulence, and 79% of virulence-defective mutants showed a normal growth in vitro, indicating that growth defects were not necessarily correlated to virulence31.”
From The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans (2021) · cites this paper as [31]
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“The growth ability30–32 and virulence factor production31 of C. albicans in the host determine the infection trend, and the former affects the latter to some extent, but the latter is not always affected by the former31.”
From The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans (2021) · cites this paper as [31]
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“It has been reported that among 674 C. albicans gene-deleted mutants, 59% of these growth-defective mutants were competent for virulence, and 79% of virulence-defective mutants showed a normal growth in vitro, indicating that growth defects were not necessarily correlated to virulence31.”
From The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans (2021) · cites this paper as [31]
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“Importantly, of these complex proteins, orf19.287 and orf19.6607 are fungus specific, and both deleted mutants are attenuated or avirulent (24).”
From Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants (2013) · cites this paper as [24]
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“Importantly, of these complex proteins, orf19.287 and orf19.6607 are fungus specific, and both deleted mutants are attenuated or avirulent (24).”
From Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants (2013) · cites this paper as [24]
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“This is consistent with the observations of Noble and co-workers that in vitro fitness is not always a reflection of virulence (Noble et al., 2010).”
From The evolution of drug resistance in clinical isolates of Candida albicans. (2015) · cites this paper as Noble et al., 2010
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Nosocomial Bloodstream Infections in United States Hospitals: A Three‐Year Analysis
Edmond, M. B., Wallace, S. E., McClish, D. K., Pfaller, M. A., Jones, R. N., & Wenzel, R. P. (1999) · Clinical Infectious Diseases · doi:10.1086/520192 · Cited by 1,387
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983
The distinct morphogenic states of Candida albicans
Sudbery, P., Gow, N., & Berman, J. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.05.008 · Cited by 876
The diploid genome sequence of Candida albicans
Jones, T., Federspiel, N. A., Chibana, H., Dungan, J. M., Kalman, S., Magee, B. B., Newport, G., Thorstenson, Y. R., Agabian, N. M., Magee, P. T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401648101 · Cited by 784
Zaoutis, T. E., Argon, J., Chu, J., Berlin, J. A., Walsh, T. J., & Feudtner, C. (2005) · Clinical Infectious Diseases · doi:10.1086/496922 · Cited by 784
Noble, S. M., & Johnson, A. D. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.2.298-309.2005 · Cited by 592
Self-citationRecombination-mediated PCR-directed plasmid construction in vivo in yeast
Oldenburg, K. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.2.451 · Cited by 516
Roemer, T., Jiang, B., Davison, J., Ketela, T. W., Veillette, K., Breton, A., Tandia, F., Linteau, A., Sillaots, S., Marta, C., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03697.x · Cited by 513
Morphogenesis in Candida albicans
Whiteway, M. S., & Bachewich, C. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093341 · Cited by 408
Rocha, C. R. C., Schröppel, K., Harcus, D., Marcil, A., Dignard, D., Taylor, B. N., Thomas, D. Y., Whiteway, M. S., & Leberer, E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3631 · Cited by 349
Research works printed but not linked: 1
- Ausubel, F.M. et al. (eds.) Current Protocols in Molecular Biology (John Wiley & Sons, New York, 1990).
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Self-citationCandida albicans mutant construction and characterization of selected virulence determinants
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Singh, A., Rella, A., Schwacke, J. H., Vacchi‐Suzzi, C., Luberto, C., & Poeta, M. D. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1613-y · Cited by 8
Zamith‐Miranda, D., Heyman, H. M., Couvillion, S., Cordero, R. J. B., Rodrigues, M. L., Nimrichter, L., Casadevall, A., Amatuzzi, R. F., Alves, L. R., Nakayasu, E. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.04.368472 · Cited by 8
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Lai, W., Chang, T.-W., Wu, C. H., Yang, S., Lee, T.-L., Li, W.-C., Chien, T., Cheng, Y., & Shieh, J. (2016) · Scientific Reports · doi:10.1038/srep33716 · Cited by 7
Sun, Q., Dong, B., Yang, D., Yu, J., Ren, T., Wang, T., Yang, L., Lü, Y., & Su, C. (2022) · Molecular Microbiology · doi:10.1111/mmi.15015 · Cited by 6
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Lo, T. L., Wang, Q., Nickson, J., van Denderen, B. J. W., Lucas, D. D., Chai, H. X., Knott, G. J., Weerasinghe, H., & Traven, A. (2024) · mSphere · doi:10.1128/msphere.00696-23 · Cited by 3
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Metadata
- Authors
- Noble, S. M., French, S., Kohn, L. A., Chen, V., & Johnson, A. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Noble, Suzanne M
- Venue
- Nature Genetics
- Published
- 2010-06-13
- Volume
- 42
- Issue
- 7
- Pages
- 590-598
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2893244
- OpenAlex
- W2139307267
- Cited by
- 678
- References
- 50
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 31 · 2023: 31 · 2022: 35 · 2021: 53 · 2020: 46 · 2019: 51 · 2018: 45 · 2017: 51 · 2016: 51 · 2015: 50 · 2014: 42 · 2013: 51 · 2012: 45
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Public Health Service (R01 A149187)
- National Institute of Allergy and Infectious Diseases (K08AI062800)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, virulence, infectivity, mouse infection model, glucosylceramide, glycolipids, cell proliferation, fungal pathogenicity
- MeSH terms
- Animals, Candida albicans, Candidiasis, Female, Fungal Proteins, Glucosylceramides, Homozygote, Humans, Mice, Inbred BALB C, Morphogenesis, Mutation, Virulence, Molecular Structure, Gene Library, Survival Analysis, Gene Deletion, Hyphae, Mice
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