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Cited by 197

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

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Enciso-Mora, Victor, Broderick, Peter, Ma, Yussanne, Jarrett, Ruth F, Hjalgrim, Henrik, Hemminki, Kari, van den Berg, Anke, Olver, Bianca, Lloyd, Amy, Dobbins, Sara E, Lightfoot, Tracy, van Leeuwen, Flora E, Försti, Asta, Diepstra, Arjan, Broeks, Annegien, Vijayakrishnan, Jayaram, Shield, Lesley, Lake, Annette, Montgomery, Dorothy, Roman, Eve, Engert, Andreas, von Strandmann, Elke Pogge, Reiners, Katrin S, Nolte, Ilja M, Smedby, Karin E, Adami, Hans-Olov, Russell, Nicola S, Glimelius, Bengt, Hamilton-Dutoit, Stephen, de Bruin, Marieke, Ryder, Lars P, Molin, Daniel, Sorensen, Karina Meden, Chang, Ellen T, Taylor, Malcolm, Cooke, Rosie, Hofstra, Robert, Westers, Helga, van Wezel, Tom, van Eijk, Ronald, Ashworth, Alan, Rostgaard, Klaus, Melbye, Mads, Swerdlow, Anthony J, Houlston, Richard S·2010·Nature Genetics

Abstract

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10−8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10−13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10−8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10−50). These data provide new insight into the pathogenesis of cHL.

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Metadata

Authors
Enciso-Mora, V., Broderick, P., Ma, Y., Jarrett, R. F., Hjalgrim, H., Hemminki, K., van den Berg, A., Olver, B., Lloyd, A., Dobbins, S. E., Lightfoot, T., van Leeuwen, F. E., Försti, A., Diepstra, A., Broeks, A., Vijayakrishnan, J., Shield, L., Lake, A., Montgomery, D., Roman, E., Engert, A., von Strandmann, E. P., Reiners, K. S., Nolte, I. M., Smedby, K. E., Adami, H.-O., Russell, N. S., Glimelius, B., Hamilton-Dutoit, S., de Bruin, M., Ryder, L. P., Molin, D., Sorensen, K. M., Chang, E. T., Taylor, M., Cooke, R., Hofstra, R., Westers, H., van Wezel, T., van Eijk, R., Ashworth, A., Rostgaard, K., Melbye, M., Swerdlow, A. J., & Houlston, R. S.
Venue
Nature Genetics
Published
2010-10-31
Volume
42
Issue
12
Pages
1126-1130
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2142363806
Cited by
197
References
7
FWCI
9.23
Type
journal article
Language
en
Open access
green

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