The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia
Open accessAbstract
Although five-year survival rates for childhood acute lymphoblastic leukemia (ALL) are now over 80% in most industrialized countries, not all children have benefited equally from this progress. Ethnic differences in survival after childhood ALL have been reported in many clinical studies, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians. The causes of ethnic differences remain uncertain, although both genetic and non-genetic factors are likely important. Interrogating genome-wide germline SNP genotypes in an unselected large cohort of children with ALL, we observed that the component of genomic variation that co-segregated with Native American ancestry was associated with risk of relapse (P = 0.0029) even after adjusting for known prognostic factors (P = 0.017). Ancestry-related differences in relapse risk were abrogated by the addition of a single extra phase of chemotherapy, indicating that modifications to therapy can mitigate the ancestry-related risk of relapse.
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A Proportional Hazards Model for the Subdistribution of a Competing Risk
Fine, J. P., & Gray, R. J. (1999) · Journal of the American Statistical Association · doi:10.1080/01621459.1999.10474144 · Cited by 14,290
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
Racial and ethnic differences in survival of children with acute lymphoblastic leukemia
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Cited by
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference
Maples, B. K., Gravel, S., Kenny, E. E., & Bustamante, C. D. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.06.020 · Cited by 900
A compendium of chromatin contact maps reveals spatially active regions in the human genome
Schmitt, A. D., Hu, M., Jung, I., Xu, Z., Qiu, Y., Tan, C. L., Li, Y., Lin, S., Lin, Y., Barr, C. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.061 · Cited by 866
Malard, F., & Mohty, M. (2020) · The Lancet · doi:10.1016/s0140-6736(19)33018-1 · Cited by 773
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Metadata
- Authors
- Yang, J. J., Cheng, C., Devidas, M., Cao, X., Fan, Y., Campana, D., Yang, W., Neale, G., Cox, N. J., Scheet, P., Borowitz, M. J., Winick, N. J., Martin, P. L., Willman, C. L., Bowman, W. P., Camitta, B. M., Carroll, A., Reaman, G. H., Carroll, W. L., Loh, M., Hunger, S. P., Pui, C.-H., Evans, W. E., & Relling, M. V.
- Venue
- Nature Genetics
- Published
- 2011-02-06
- Volume
- 43
- Issue
- 3
- Pages
- 237-241
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2060343635
- Cited by
- 274
- References
- 3
- FWCI
- 28.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, J. J., Cheng, C., Devidas, M., Cao, X., Fan, Y., Campana, D., Yang, W., Neale, G., Cox, N. J., Scheet, P., Borowitz, M. J., Winick, N. J., Martin, P. L., Willman, C. L., Bowman, W. P., Camitta, B. M., Carroll, A., Reaman, G. H., Carroll, W. L., . . . Relling, M. V. (2011). Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nature Genetics. https://doi.org/10.1038/ng.763
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