The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Open accessAbstract
Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87 × 10−12), a locus on chromosome 10p14 (P = 1.79 × 10−15) and a gene-rich region on chromosome 12q13 (P = 2.33 × 10−13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07 × 10−23), which is close to rs2070600, a SNP previously reported for association with FEV1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
Discovering susceptibility genes for asthma and allergy
Vercelli, D. (2008) · Nature Reviews Immunology · doi:10.1038/nri2257 · Cited by 635
Luca, D., Ringquist, S., Klei, L., Lee, A. B., Gieger, C., Wichmann, H.-E., Schreiber, S., Krawczak, M., Lu, Y., Styche, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.11.003 · Cited by 128
Cited by
Gittler, J. K., Shemer, A., Suárez-Fariñas, M., Fuentes-Duculan, J., Gulewicz, K. J., Wang, C. Q. F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J. G., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.012 · Cited by 981
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557
Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis
Noti, M., Wojno, E. D. T., Kim, B. S., Siracusa, M. C., Giacomin, P. R., Nair, M. G., Benitez, A. J., Ruymann, K. R., Muir, A. B., Hill, D. A., et al. (2013) · Nature Medicine · doi:10.1038/nm.3281 · Cited by 422
Self-citationLung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
Hao, K., Bossé, Y., Nickle, D. C., Paré, P. D., Postma, D. S., Laviolette, M., Sandford, A., Hackett, T. L., Daley, D., Hogg, J. C., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003029 · Cited by 309
Role of thymic stromal lymphopoietin in allergy and beyond
Ebina-Shibuya, R., & Leonard, W. J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00735-y · Cited by 289
Metadata
- Authors
- Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Doi, S., Fujita, K., Miyatake, A., Enomoto, T., Miyagawa, T., Adachi, M., Tanaka, H., Niimi, A., Matsumoto, H., Ito, I., Masuko, H., Sakamoto, T., Hizawa, N., Taniguchi, M., Lima, J. J., Irvin, C. G., Peters, S. P., Himes, B. E., Litonjua, A. A., Tantisira, K. G., Weiss, S. T., Kamatani, N., Nakamura, Y., & Tamari, M.
- Venue
- Nature Genetics
- Published
- 2011-07-31
- Volume
- 43
- Issue
- 9
- Pages
- 893-896
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2019966611
- Cited by
- 324
- References
- 4
- FWCI
- 23.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Doi, S., Fujita, K., Miyatake, A., Enomoto, T., Miyagawa, T., Adachi, M., Tanaka, H., Niimi, A., Matsumoto, H., Ito, I., Masuko, H., Sakamoto, T., Hizawa, N., Taniguchi, M., . . . Tamari, M. (2011). Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nature Genetics. https://doi.org/10.1038/ng.887
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