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Cited by 428

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Open access
LifeLines Cohort Study, Wain, Louise V, EchoGen consortium, AortaGen Consortium, CHARGE Consortium Heart Failure Working Group, KidneyGen consortium, CKDGen consortium, Cardiogenics consortium, CardioGram, Verwoert, Germaine C, O'Reilly, Paul F, Shi, Gang, Johnson, Toby, Johnson, Andrew D, Bochud, Murielle, Rice, Kenneth M, Henneman, Peter, Smith, Albert V, Ehret, Georg B, Amin, Najaf, Larson, Martin G, Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J W, Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'an, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U, Webster, Rebecca J, Zhang, Feng, Peden, John F, Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I, Trompet, Stella, Bragg-Gresham, Jennifer L, Alizadeh, Behrooz Z, Chambers, John C, Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M, Polašek, Ozren, Boban, Mladen, Nelson, Christopher P, Morrison, Alanna C, Pihur, Vasyl, Ganesh, Santhi K, Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U S, Rivadeneira, Fernando, Sijbrands, Eric J G, Uitterlinden, Andre G, Hwang, Shih-Jen, Vasan, Ramachandran S, Wang, Thomas J, Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L, Kroemer, Heyo K, Völker, Uwe, Völzke, Henry, Glazer, Nicole L, Taylor, Kent D, Harris, Tamara B, Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, Inês, Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M, Penninx, Brenda W, Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, d'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S, Bergman, Richard N, Beilby, John P, Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S, Navarro, Pau, Wild, Sarah H, Corsi, Anna Maria, Singleton, Andrew, de Geus, Eco J C, Willemsen, Gonneke, Parker, Alex N, Rose, Lynda M, Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, van der Klauw, Melanie M, Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M, Emilsson, Valur, Plump, Andrew, Lindeman, Jan H, Hoen, Peter A C 't, König, Inke R, Felix, Janine F, Clarke, Robert, Hopewell, Jemma C, Ongen, Halit, Breteler, Monique, Debette, Stéphanie, DeStefano, Anita L, Fornage, Myriam, Mitchell, Gary F, Smith, Nicholas L, Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J, Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J, Wichmann, H-Erich, Raitakari, Olli T, Palmas, Walter, Kooner, Jaspal S, Stolk, Ronald P, Jukema, J Wouter, Wright, Alan F, Boomsma, Dorret I, Bandinelli, Stefania, Gyllensten, Ulf B, Wilson, James F, Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D, Palmer, Lyle J, Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth J F, Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J, Oostra, Ben A, Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P, Beckmann, Jacques S, Witteman, Jacqueline C M, Erdmann, Jeanette, van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M, Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R, Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B, Psaty, Bruce M, Caulfield, Mark J, Rao, Dabeeru C, Tobin, Martin D, Elliott, Paul, van Duijn, Cornelia M·2011·Nature Genetics
DOI 10.1038/ng.922
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Abstract

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10−8 to P = 2.3 × 10−13) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

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Authors
Study, L. C., Wain, L. V., EchoGen consortium, AortaGen Consortium, CHARGE Consortium Heart Failure Working Group, KidneyGen consortium, CKDGen consortium, Cardiogenics consortium, CardioGram, Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V., Ehret, G. B., Amin, N., Larson, M. G., Mooser, V., Hadley, D., Dörr, M., Bis, J. C., Aspelund, T., Esko, T., Janssens, A. C. J. W., Zhao, J. H., Heath, S., Laan, M., Fu, J., Pistis, G., Luan, J., Arora, P., Lucas, G., Pirastu, N., Pichler, I., Jackson, A. U., Webster, R. J., Zhang, F., Peden, J. F., Schmidt, H., Tanaka, T., Campbell, H., Igl, W., Milaneschi, Y., Hottenga, J.-J., Vitart, V., Chasman, D. I., Trompet, S., Bragg-Gresham, J. L., Alizadeh, B. Z., Chambers, J. C., Guo, X., Lehtimäki, T., Kühnel, B., Lopez, L. M., Polašek, O., Boban, M., Nelson, C. P., Morrison, A. C., Pihur, V., Ganesh, S. K., Hofman, A., Kundu, S., Mattace-Raso, F. U. S., Rivadeneira, F., Sijbrands, E. J. G., Uitterlinden, A. G., Hwang, S.-J., Vasan, R. S., Wang, T. J., Bergmann, S., Vollenweider, P., Waeber, G., Laitinen, J., Pouta, A., Zitting, P., McArdle, W. L., Kroemer, H. K., Völker, U., Völzke, H., Glazer, N. L., Taylor, K. D., Harris, T. B., Alavere, H., Haller, T., Keis, A., Tammesoo, M.-L., Aulchenko, Y., Barroso, I., Khaw, K.-T., Galan, P., Hercberg, S., Lathrop, M., Eyheramendy, S., Org, E., Sõber, S., Lu, X., Nolte, I. M., Penninx, B. W., Corre, T., Masciullo, C., Sala, C., Groop, L., Voight, B. F., Melander, O., O'Donnell, C. J., Salomaa, V., d'Adamo, A. P., Fabretto, A., Faletra, F., Ulivi, S., Del Greco M, F., Facheris, M., Collins, F. S., Bergman, R. N., Beilby, J. P., Hung, J., Musk, A. W., Mangino, M., Shin, S.-Y., Soranzo, N., Watkins, H., Goel, A., Hamsten, A., Gider, P., Loitfelder, M., Zeginigg, M., Hernandez, D., Najjar, S. S., Navarro, P., Wild, S. H., Corsi, A. M., Singleton, A., de Geus, E. J. C., Willemsen, G., Parker, A. N., Rose, L. M., Buckley, B., Stott, D., Orru, M., Uda, M., van der Klauw, M. M., Zhang, W., Li, X., Scott, J., Chen, Y.-D. I., Burke, G. L., Kähönen, M., Viikari, J., Döring, A., Meitinger, T., Davies, G., Starr, J. M., Emilsson, V., Plump, A., Lindeman, J. H., Hoen, P. A. C. '., König, I. R., Felix, J. F., Clarke, R., Hopewell, J. C., Ongen, H., Breteler, M., Debette, S., DeStefano, A. L., Fornage, M., Mitchell, G. F., Smith, N. L., Holm, H., Stefansson, K., Thorleifsson, G., Thorsteinsdottir, U., Samani, N. J., Preuss, M., Rudan, I., Hayward, C., Deary, I. J., Wichmann, H.-E., Raitakari, O. T., Palmas, W., Kooner, J. S., Stolk, R. P., Jukema, J. W., Wright, A. F., Boomsma, D. I., Bandinelli, S., Gyllensten, U. B., Wilson, J. F., Ferrucci, L., Schmidt, R., Farrall, M., Spector, T. D., Palmer, L. J., Tuomilehto, J., Pfeufer, A., Gasparini, P., Siscovick, D., Altshuler, D., Loos, R. J. F., Toniolo, D., Snieder, H., Gieger, C., Meneton, P., Wareham, N. J., Oostra, B. A., Metspalu, A., Launer, L., Rettig, R., Strachan, D. P., Beckmann, J. S., Witteman, J. C. M., Erdmann, J., van Dijk, K. W., Boerwinkle, E., Boehnke, M., Ridker, P. M., Jarvelin, M.-R., Chakravarti, A., Abecasis, G. R., Gudnason, V., Newton-Cheh, C., Levy, D., Munroe, P. B., Psaty, B. M., Caulfield, M. J., Rao, D. C., Tobin, M. D., Elliott, P., & van Duijn, C. M.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2011-09-11
Volume
43
Issue
10
Pages
1005-1011
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.922
OpenAlex
W2102622802
Cited by
428
References
4
FWCI
21.56
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. https://app.cochat.ai/papers/10.1038/ng.922
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Study, L. C., Wain, L. V., EchoGen consortium, AortaGen Consortium, CHARGE Consortium Heart Failure Working Group, KidneyGen consortium, CKDGen consortium, Cardiogenics consortium, CardioGram, Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V., Ehret, G. B., . . . van Duijn, C. M. (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics. https://doi.org/10.1038/ng.922

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