Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 240

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Genome-wide association study identifies three new melanoma susceptibility loci

Open access
Barrett, Jennifer H, Iles, Mark M, Harland, Mark, Taylor, John C, Aitken, Joanne F, Andresen, Per Arne, Akslen, Lars A, Armstrong, Bruce K, Avril, Marie-Francoise, Azizi, Esther, Bakker, Bert, Bergman, Wilma, Bianchi-Scarrà, Giovanna, Bressac-de Paillerets, Brigitte, Calista, Donato, Cannon-Albright, Lisa A, Corda, Eve, Cust, Anne E, Dębniak, Tadeusz, Duffy, David, Dunning, Alison M, Easton, Douglas F, Friedman, Eitan, Galan, Pilar, Ghiorzo, Paola, Giles, Graham G, Hansson, Johan, Hocevar, Marko, Höiom, Veronica, Hopper, John L, Ingvar, Christian, Janssen, Bart, Jenkins, Mark A, Jönsson, Göran, Kefford, Richard F, Landi, Giorgio, Landi, Maria Teresa, Lang, Julie, Lubiński, Jan, Mackie, Rona, Malvehy, Josep, Martin, Nicholas G, Molven, Anders, Montgomery, Grant W, van Nieuwpoort, Frans A, Novakovic, Srdjan, Olsson, Håkan, Pastorino, Lorenza, Puig, Susana, Puig-Butille, Joan Anton, Randerson-Moor, Juliette, Snowden, Helen, Tuominen, Rainer, Van Belle, Patricia, van der Stoep, Nienke, Whiteman, David C, Zelenika, Diana, Han, Jiali, Fang, Shenying, Lee, Jeffrey E, Wei, Qingyi, Lathrop, G Mark, Gillanders, Elizabeth M, Brown, Kevin M, Goldstein, Alisa M, Kanetsky, Peter A, Mann, Graham J, MacGregor, Stuart, Elder, David E, Amos, Christopher I, Hayward, Nicholas K, Gruis, Nelleke A, Demenais, Florence, Bishop, Julia A Newton, Bishop, D Timothy·2011·Nature Genetics
DOI 10.1038/ng.959
Open this paper in CoChat — free account

Abstract

We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10−5 and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10−3: an SNP in ATM (rs1801516, overall P = 3.4 × 10−9), an SNP in MX2 (rs45430, P = 2.9 × 10−9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10−10). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10−7 under a fixed-effects model and P = 1.2 × 10−3 under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ng.959

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Cited by

See all 240

Metadata

Authors
Barrett, J. H., Iles, M. M., Harland, M., Taylor, J. C., Aitken, J. F., Andresen, P. A., Akslen, L. A., Armstrong, B. K., Avril, M.-F., Azizi, E., Bakker, B., Bergman, W., Bianchi-Scarrà, G., Bressac-de Paillerets, B., Calista, D., Cannon-Albright, L. A., Corda, E., Cust, A. E., Dębniak, T., Duffy, D., Dunning, A. M., Easton, D. F., Friedman, E., Galan, P., Ghiorzo, P., Giles, G. G., Hansson, J., Hocevar, M., Höiom, V., Hopper, J. L., Ingvar, C., Janssen, B., Jenkins, M. A., Jönsson, G., Kefford, R. F., Landi, G., Landi, M. T., Lang, J., Lubiński, J., Mackie, R., Malvehy, J., Martin, N. G., Molven, A., Montgomery, G. W., van Nieuwpoort, F. A., Novakovic, S., Olsson, H., Pastorino, L., Puig, S., Puig-Butille, J. A., Randerson-Moor, J., Snowden, H., Tuominen, R., Van Belle, P., van der Stoep, N., Whiteman, D. C., Zelenika, D., Han, J., Fang, S., Lee, J. E., Wei, Q., Lathrop, G. M., Gillanders, E. M., Brown, K. M., Goldstein, A. M., Kanetsky, P. A., Mann, G. J., MacGregor, S., Elder, D. E., Amos, C. I., Hayward, N. K., Gruis, N. A., Demenais, F., Bishop, J. A. N., & Bishop, D. T.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2011-10-09
Volume
43
Issue
11
Pages
1108-1113
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.959
OpenAlex
W2081596026
Cited by
240
References
7
FWCI
13.70
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Genome-wide association study identifies three new melanoma susceptibility loci. https://app.cochat.ai/papers/10.1038/ng.959
The paper
Barrett, J. H., Iles, M. M., Harland, M., Taylor, J. C., Aitken, J. F., Andresen, P. A., Akslen, L. A., Armstrong, B. K., Avril, M.-F., Azizi, E., Bakker, B., Bergman, W., Bianchi-Scarrà, G., Bressac-de Paillerets, B., Calista, D., Cannon-Albright, L. A., Corda, E., Cust, A. E., Dębniak, T., . . . Bishop, D. T. (2011). Genome-wide association study identifies three new melanoma susceptibility loci. Nature Genetics. https://doi.org/10.1038/ng.959

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.