The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The Knockout Mouse Project
Open accessAbstract
Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.
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“However, due to the extremely low frequency of HR, this technique cannot be used for human gene therapy.”
From Newer Gene Editing Technologies toward HIV Gene Therapy (2013) · cites this paper as [16]
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Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275
Molecular characterization of the mouse agouti locus
Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) · Cell · doi:10.1016/s0092-8674(05)80067-4 · Cited by 805
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
Valenzuela, D. M., Murphy, A. J., Frendewey, D. A., Gale, N. W., Economides, A. N., Auerbach, W., Poueymirou, W. T., Adams, N. C., Rojas, J., Yasenchak, J., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt822 · Cited by 583
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
Zambrowicz, B., Friedrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C., & Sands, A. (1998) · Nature · doi:10.1038/33423 · Cited by 436
Gene-trap mutagenesis: past, present and beyond
Stanford, W. L., Cohn, J. B., & Cordes, S. P. (2001) · Nature Reviews Genetics · doi:10.1038/35093548 · Cited by 391
Zambrowicz, B., Abuin, A., Ramírez‐Solis, R., Richter, L. J., Piggott, J. R., BeltrandelRio, H., Buxton, E. C., Edwards, J., Finch, R. A., Friddle, C. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336103100 · Cited by 330
Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype
Kunath, T., Gish, G. D., Lickert, H., Jones, N., Pawson, T. J., & Rossant, J. (2003) · Nature Biotechnology · doi:10.1038/nbt813 · Cited by 279
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells
Stryke, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg064 · Cited by 239
A public gene trap resource for mouse functional genomics
Skarnes, W. C., Nord, A. S., Cox, T., von Melchner, H., Wurst, W., Hicks, G. G., Young, S. G., Conklin, B. R., Ruiz, P., Soriano, P. M., et al. (2004) · Nature Genetics · doi:10.1038/ng0604-543 · Cited by 208
Mouse models for mitochondrial disease
Wallace, D. C. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1393 · Cited by 178
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome
Hansen, J., Floß, T., Sloun, P. P. H. V., Füchtbauer, E., Vauti, F., Arnold, H.-H., Schnütgen, F., Wurst, W., von Melchner, H., & Ruíz, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633296100 · Cited by 144
Eggan, K. C., Rode, A., Jentsch, I., Samuel, C., Hennek, T., Tintrup, H., Zevnik, B., Erwin, J. A., Loring, J. M., Jackson‐Grusby, L., et al. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-455 · Cited by 141
To knockout in 129 or in C57BL/6: that is the question
Seong, E., Saunders, T. L., Stewart, C. L., & Burmeister, M. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.12.006 · Cited by 141
Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells
Wiles, M. V., Vauti, F., Otte, J., Füchtbauer, E., Ruíz, P., Füchtbauer, A. C., Arnold, H.-H., Lehrach, H. R., Metz, T., von Melchner, H., et al. (2000) · Nature Genetics · doi:10.1038/71622 · Cited by 139
Functional Annotation of Mouse Genome Sequences
Nadeau, J. H., Balling, R., Barsh, G. S., Beier, D. R., Brown, S. D. M., Bućan, M., Camper, S. A., Carlson, G. A., Copeland, N. G., Eppig, J. T., et al. (2001) · Science · doi:10.1126/science.1058244 · Cited by 135
Chen, W. V., Delrow, J. J., Corrin, P. D., Frazier, J. P., & Soriano, P. M. (2004) · Nature Genetics · doi:10.1038/ng1306 · Cited by 110
Skeletal development: insights from targeting the mouse genome
Horton, W. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14119-0 · Cited by 69
Laskers for 2001: Knockout mice and test-tube babies
Goldstein, J. L. (2001) · Nature Medicine · doi:10.1038/nm1001-1079 · Cited by 21
Cardiovascular diseases: new insights from knockout mice
DAORLEANSJUSTE, P. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00017-1 · Cited by 12
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The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Charting a course for genomic medicine from base pairs to bedside
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Shim, J., Xiao, C., Paschal, A. E., Bailey, S. T., Rao, P., Hayden, M. S., Lee, K., Bussey, C., Steckel, M., Tanaka, N., et al. (2005) · Genes & Development · doi:10.1101/gad.1360605 · Cited by 747
Metadata
- Authors
- The Comprehensive Knockout Mouse Project Consortium
- Venue
- Nature Genetics
- Published
- 2004-09
- Volume
- 36
- Issue
- 9
- Pages
- 921-924
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2716027
- OpenAlex
- W2023630351
- Cited by
- 608
- References
- 24
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 36 · 2021: 17 · 2020: 14 · 2019: 21 · 2018: 11 · 2017: 15 · 2016: 18 · 2015: 26 · 2014: 22 · 2013: 40 · 2012: 37
- FWCI
- 30.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion, public-domain)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion, public-domain)
- Funders
- GlaxoSmithKline
- University of Pennsylvania
- Wellcome Trust (077188)
- University of Toronto
- National Institutes of Health (10021)
- National Institute of Mental Health
- National Institute on Deafness and Other Communication Disorders
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- knockout mice, gene function, phenotyping, mouse genetics
- MeSH terms
- Alleles, Animals, Phenotype, Mice, Knockout, Research Embryo Creation, Genetic Research, Mice
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