Putting a finger on the switch

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Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus

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Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

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Delayed fetal hemoglobin switching in subjects with KLF1 gene mutation

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Genetic modulators of fetal hemoglobin expression and ischemic stroke occurrence in African descendant children with sickle cell anemia

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Transcriptional Control of Gene Expression and the Heterogeneous Cellular Identity of Erythroblastic Island Macrophages

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Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells

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Survey and evaluation of mutations in the human KLF1 transcription unit

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Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny

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The Role of ZBP-89 in Globin Regulation

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Erythrocytes

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Pharmacologic Therapies in Beta Hemoglobinopathies: Fetal Globin Gene Induction in the First Molecular Diseases

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KLF1 regulates BCL11A expression and γ- to β-globin gene switching

Zhou, D., Liu, K., Sun, C.-W., Pawlik, K. M., & Townes, T. M. (2010) · Nature Genetics · doi:10.1038/ng.637 · Cited by 367 · see citing works

Delayed fetal hemoglobin switching in subjects with KLF1 gene mutation

Satta, S., Perseu, L., Maccioni, L., Giagu, N., & Galanello, R. (2011) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.10.003 · Cited by 25 · see citing works

Three fingers on the switch

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Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts

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Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

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