The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development
Open accessAbstract
Neurotrophin 3 (Nt3) is one of five neurotrophin growth factors which shape the development of the nervous system by regulating neuronal survival and differentiation. Peripheral neuronal subpopulations expressing the TrkC receptor tyrosine kinase respond to Nt3 with enhanced survival, mitogenesis or cell migration1–3 and these neurons are lost in homozygous Nt3 null (−/−) mutant mice4–7. The unexplained perinatal lethality in the Nt3 −/− mice, however, suggests a wider function for this neurotrophin. Here we report that Nt3 is essential for the normal development of atria, ventricles, and cardiac outflow tracts. Histological and echocardiographic image analysis of Nt3 −/− animals reveal severe cardiovascular abnormalities including atrial and ventricular septal defects, and tetralogy of Fallot, resembling some of the most common congenital malformations in humans. The observed defects are consistent with abnormalities in the survival and/or migration of cardiac neural crest early in embryogenesis8 and establish an essential role for neurotrophin 3 in regulating the development of the mammalian heart.
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Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F., & Copeland, N. G. (1994) · Genes & Development · doi:10.1101/gad.8.9.1019 · Cited by 641
Cited by
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
Crispino, J. D., Lodish, M. B., Thurberg, B. L., Litovsky, S. H., Collins, T., Molkentin, J. D., & Orkin, S. H. (2001) · Genes & Development · doi:10.1101/gad.875201 · Cited by 316
von Schack, D., Casademunt, E., Schweigreiter, R., Meyer, M., Bibel, M., & Dechant, G. (2001) · Nature Neuroscience · doi:10.1038/nn730 · Cited by 259
Metadata
- Authors
- Donovan, M. J., Hahn, R., Tessarollo, L., & Hempstead, B. L.
- Venue
- Nature Genetics
- Published
- 1996-10
- Volume
- 14
- Issue
- 2
- Pages
- 210-213
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2001632160
- Cited by
- 160
- References
- 1
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Donovan, M. J., Hahn, R., Tessarollo, L., & Hempstead, B. L. (1996). Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nature Genetics. https://doi.org/10.1038/ng1096-210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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