The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

The BRCT Domain Is a Phospho-Protein Binding Domain

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

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Crosslinks and crosstalk

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FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice

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Analysis of Pathogenic Pseudoexons Reveals Novel Mechanisms Driving Cryptic Splicing

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The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function

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Mutation analysis of BRIP1/BACH1 in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives

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BRIP1 variations analysis reveals their relative importance as genetic susceptibility factor for cervical cancer

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Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia‐derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption

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FANCJ is essential to maintain microsatellite structure genome-wide during replication stress

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FANCJ Helicase Operates in the Fanconi Anemia DNA Repair Pathway and the Response to Replicational Stress

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Fanconi Anemia: Causes and Consequences of Genetic Instability

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Differential p53 Engagement in Response to Oxidative and Oncogenic Stresses in Fanconi Anemia Mice

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DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity

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BACH1 Ser919Pro variant and breast cancer risk

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Rescue of replication failure by Fanconi anaemia proteins

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A requirement of FancL and FancD2 monoubiquitination in DNA repair

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Myeloid lineage‐selective growth of revertant cells in Fanconi anaemia

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The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics

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Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism

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Constitutive role of the Fanconi anemia D2 gene in the replication stress response

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DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy

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Helicase-inactivating mutations as a basis for dominant negative phenotypes

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Beyond base excision repair: an evolving picture of mitochondrial DNA repair

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Two steps forward, one step back: Determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers

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FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses

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Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression

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An Arabidopsis FANCJ helicase homologue is required for DNA crosslink repair and rDNA repeat stability

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Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair

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Exploring the link between MORF4L1 and risk of breast cancer

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Rare germline mutations in African American men diagnosed with early‐onset prostate cancer

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A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

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Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family

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Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells

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A novel Leu153Ser mutation of the Fanconi anemia FANCD2 gene is associated with severe chemotherapy toxicity in a pediatric T-cell acute lymphoblastic leukemia

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FANCJ is essential to maintain microsatellite structure genome-wide during replication stress

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Challenges in the identification and use of rare disease-associated predisposition variants

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Fanconi Anemia and Ubiquitination

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FAVL impairment of the Fanconi anemia pathway promotes the development of human bladder cancer

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Involvement of FANCD2 in Energy Metabolism via ATP5α

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Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression

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The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC

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BRCA-FA Pathway as a Target for Anti-Tumor Drugs

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Towards a Molecular Understanding of the Fanconi Anemia Core Complex

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Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis

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The involvement of FANCM, FANCI, and checkpoint proteins in the interstrand DNA crosslink repair pathway is conserved in C. elegans

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Molecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease

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Bone Marrow Failure: A Child Is Not Just a Small Adult (But an Adult Can Have a Childhood Disease)

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BRIP1 rs10744996C>A variant increases the risk of chronic obstructive pulmonary disease in the Mongolian population of northern China

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DNA Repair: Exploiting the Fanconi Anemia Pathway As a Potential Therapeutic Target

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An emerging picture of FANCJ’s role in G4 resolution to facilitate DNA replication

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The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization

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An MLH1 Mutation Links BACH1/FANCJ to Colon Cancer, Signaling, and Insight toward Directed Therapy

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Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families

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Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles

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Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance

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Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

Colnaghi, L., Jones, M. V., Cotto-Rios, X. M., Schindler, D., Hanenberg, H., & Huang, T. T. (2010) · Blood · doi:10.1182/blood-2010-07-295758 · Cited by 20

Activation of the FA pathway mediated by phosphorylation and ubiquitination

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Validation of Fanconi anemia complementation Group A assignment using molecular analysis

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Helicases as Prospective Targets for Anti-Cancer Therapy

Gupta, R., & Brosh, R. M. (2008) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152008784220339 · Cited by 22

First evidence for the contribution of the genetic variations of BRCA1-interacting protein 1 (BRIP1) to the genetic susceptibility of cervical cancer

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FAN1 variants identified in multiple-case early-onset breast cancer families via exome sequencing: no evidence for association with risk for breast cancer

Park, D. J., Odefrey, F., Hammet, F., Giles, G. G., Baglietto, L., Abcfs, MCCS, Hopper, J. L., Schmidt, D. F., Makalic, E., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1704-y · Cited by 21

Structural mechanism underpinning Thermus oshimai Pif1‐mediated G‐quadruplex unfolding

Dai, Y., Guo, H.-L., Liu, N.-N., Chen, W.-F., Ai, X., Li, H.-H., Sun, B., Hou, X.-M., Réty, S., & Xi, X.-G. (2022) · EMBO Reports · doi:10.15252/embr.202153874 · Cited by 14

Helicases and human diseases

Uchiumi, F., Seki, M., & Furuichi, Y. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00039 · Cited by 19

BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity

Zou, W., Ma, X., Hua, W., Chen, B., Huang, Y., Wang, D., & CAI, G. (2015) · Oncology Letters · doi:10.3892/ol.2015.3963 · Cited by 19

Real-time Investigation of SV40 Large T-antigen Helicase Activity Using Surface Plasmon Resonance

Plyler, J. R., Jasheway, K. R., Tuesuwan, B., Karr, J. R., Brennan, J., Kerwin, S. M., & David, W. M. (2008) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-008-9038-z · Cited by 19

Focal Point of Fanconi Anemia Signaling

Zhan, S., Siu, J., Wang, Z., Yu, H., Bezabeh, T., Deng, Y., Du, W., & Fei, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312976 · Cited by 18

Comparative genomics and selection analysis of Yeonsan Ogye black chicken with whole-genome sequencing

Cho, Y., Kim, J., & Kim, N. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110298 · Cited by 20

The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

Takata, M., Ishiai, M., & Kitao, H. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.12.012 · Cited by 18

Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

Sommers, J. A., Suhasini, A. N., & Brosh, R. M. (2015) · Biomolecules · doi:10.3390/biom5020590 · Cited by 19

Association between BRIP1 (BACH1) polymorphisms and breast cancer risk: a meta-analysis

Pabalan, N., Jarjanazi, H., & Özçelik, H. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2364-2 · Cited by 19

Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer

Gallmeier, E., Hucl, T., Calhoun, E. S., Cunningham, S. C., Bunz, F., Brody, J. R., & Kern, S. E. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.5.3978 · Cited by 18

The Fanconi Anemia Core Complex Acts as a Transcriptional Co-regulator in Hairy Enhancer of Split 1 Signaling

Tremblay, C. S., Huard, C., Huang, F., Habi, O., Bourdages, V., Lévesque, G., & Carreau, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807921200 · Cited by 19

Exonization of a LINE1 fragment implicated in X-linked hypohidrotic ectodermal dysplasia in cattle

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Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer

Ameziane, N., van den Ouweland, A. M. W., Adank, M. A., Vijzelaar, R., Errami, A., Dorsman, J. C., Joenje, H., Meijers-Heijboer, H. E. J., & Waisfisz, Q. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0428-8 · Cited by 19

The ubiquitin family meets the Fanconi anemia proteins

Renaudin, X., Lerner, L. K., Menck, C. F. M., & Rosselli, F. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.06.004 · Cited by 18

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

Clark, D. W., Tripathi, K. K., Dorsman, J. C., & Palle, K. (2015) · Oncotarget · doi:10.18632/oncotarget.5006 · Cited by 17

Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins

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FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids

Nath, S., Somyajit, K., Mishra, A., Scully, R., & Nagaraju, G. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx586 · Cited by 17

hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ

Xu, Y., Wu, X., & Her, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.642884 · Cited by 19

Topo IIIα and BLM Act within the Fanconi Anemia Pathway in Response to DNA-Crosslinking Agents

Hemphill, A., Akkari, Y. M. N., Newell, A. H., Schultz, R. A., Grompe, M., North, P. S., Hickson, I. D., Jakobs, P. M., Rennie, S., Pauw, D., et al. (2009) · Cytogenetic and Genome Research · doi:10.1159/000230001 · Cited by 19

Advances in the understanding of the Fanconi anemia tumor suppressor pathway

Pickering, A., Zhang, J., Panneerselvam, J., & Fei, P. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.26380 · Cited by 18

Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle

Kaddar, T., & Carreau, M. (2012) · Anemia · doi:10.1155/2012/425814 · Cited by 16

CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans

Chung, G., O’Neil, N. J., & Rose, A. M. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.09.011 · Cited by 16

Clinical characteristics and genetic subtypes of Fanconi anemia in Saudi patients

Ghazwani, Y. Q., Balwi, M. A. A., Alabdulkareem, I. B., Al-Dress, M., Al‐Harbi, T., Al-Sudairy, R. M., Alomari, A., Aljamaan, K., Essa, M. A., Alzahrani, M., et al. (2016) · Cancer Genetics · doi:10.1016/j.cancergen.2016.02.003 · Cited by 16

HP1 regulates the localization of FANCJ at sites of DNA double‐strand breaks

Wu, W., Togashi, Y., Johmura, Y., Miyoshi, Y., Nobuoka, S., Nakanishi, M., & Ohta, T. (2016) · Cancer Science · doi:10.1111/cas.13008 · Cited by 16

A comprehensive molecular study identified 12 complementation groups with 56 novel FANC gene variants in Indian Fanconi anemia subjects

George, M., Solanki, A., Chavan, N., Rajendran, A., Raj, R., Mohan, S., Nemani, S., Kanvinde, S., Munirathnam, D., Rao, S. C., et al. (2021) · Human Mutation · doi:10.1002/humu.24286 · Cited by 15

RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS

Huang, Y.-J., Chen, J., Yan, M., Davis, A. G., Miyauchi, S., Chen, L., Hao, Y., Katz, S., Bejar, R. L., Abdel-Wahab, O. I., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007804 · Cited by 17

Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations

Guo, M., Vidhyasagar, V., Ding, H., & Wu, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.538892 · Cited by 18

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families

Fernández‐Rodríguez, J., Quiles, F., Blanco, I., Teulé, À., Feliubadaló, L., Valle, J. D., Salinas, M., Izquierdo, Á., Darder, E., Schindler, D., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-84 · Cited by 16

Hawaii natural compounds are promising to reduce ovarian cancer deaths

Fei‐Zhang, D. J., Li, C., & Cao, S. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1178428 · Cited by 15

Heterozygous Mutations in DNA Repair Genes and Hereditary Breast Cancer: A Question of Power

Ellis, N. A., & Offit, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003008 · Cited by 16

Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism

Crouch, J. D., & Brosh, R. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.022 · Cited by 15

The phenotype of FancB-mutant mouse embryonic stem cells

Kim, T. M., Ko, J. H., Choi, Y. J., Hu, L., & Hasty, P. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.03.010 · Cited by 15

A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck

Liu, H., Gao, F., Dahlstrom, K. R., Li, G., Sturgis, E. M., Zevallos, J. P., Wei, Q., & Liu, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-4682-6 · Cited by 14

Loss of heterozygosity in FANCG, FANCF and BRIP1 from head and neck squamous cell carcinoma of the oral cavity

Türke, C., Horn, S., Petto, C., Labudde, D., Lauer, G., & Wittenburg, G. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3974 · Cited by 14

The role of the Fanconi anemia network in the response to DNA replication stress

Gari, K., & Constantinou, A. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903154150 · Cited by 14

Upregulated ATM Gene Expression and Activated DNA Crosslink-Induced Damage Response Checkpoint in Fanconi Anemia: Implications for Carcinogenesis

Yamamoto, K., Nihrane, A., Aglipay, J. A., Sironi, J., Arkin, S., Lipton, J. M. M., Ouchi, T., & Liu, J. M. (2008) · Molecular Medicine · doi:10.2119/2007-00122.yamamoto · Cited by 14

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370

FANCJ Helicase Operates in the Fanconi Anemia DNA Repair Pathway and the Response to Replicational Stress

Wu, Y., & Brosh, R. M. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167159 · Cited by 37

FANCJ: Solving problems in DNA replication

Hiom, K. J. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.005 · Cited by 41

Unraveling the Fanconi anaemia-DNA repair connection through DNA helicase and translocase activities

Thompson, L. H. (2005) · University of North Texas Digital Library (University of North Texas)

Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes

Wu, Y., Sommers, J. A., Suhasini, A. N., Leonard, T., Deakyne, J. S., Mazin, A. V., Shin-ya, K., Kitao, H., & Brosh, R. M. (2010) · Blood · doi:10.1182/blood-2009-11-256016 · Cited by 72