The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies
Open accessAbstract
The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.
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Self-citationHigh-Resolution Whole-Genome Association Study of Parkinson Disease
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Wang, S., Ray, N., Rojas, W., Parra, M. V., Bedoya, G., Gallo, C., Poletti, G., Mazzotti, G., Hill, K., Hurtado, A. M., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000037 · Cited by 453
Self-citationRecent human effective population size estimated from linkage disequilibrium
Tenesa, A., Navarro, P., Hayes, B. J., Duffy, D. L., Clarke, G. M., Goddard, M. E., & Visscher, P. M. (2007) · Genome Research · doi:10.1101/gr.6023607 · Cited by 438
Metadata
- Authors
- Service, S., DeYoung, J., Karayiorgou, M., Roos, J. L., Pretorious, H., Bedoya, G., Ospina, J., Ruiz-Linares, A., Macedo, A., Palha, J. A., Heutink, P., Aulchenko, Y., Oostra, B., van Duijn, C., Jarvelin, M.-R., Varilo, T., Peddle, L., Rahman, P., Piras, G., Monne, M., Murray, S., Galver, L., Peltonen, L., Sabatti, C., Collins, A., & Freimer, N.
- Venue
- Nature Genetics
- Published
- 2006-04-02
- Volume
- 38
- Issue
- 5
- Pages
- 556-560
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2024642024
- Cited by
- 273
- References
- 30
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Service, S., DeYoung, J., Karayiorgou, M., Roos, J. L., Pretorious, H., Bedoya, G., Ospina, J., Ruiz-Linares, A., Macedo, A., Palha, J. A., Heutink, P., Aulchenko, Y., Oostra, B., van Duijn, C., Jarvelin, M.-R., Varilo, T., Peddle, L., Rahman, P., Piras, G., . . . Freimer, N. (2006). Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nature Genetics. https://doi.org/10.1038/ng1770
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