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Cited by 453Forensic and Genetic ResearchGenetic diversity and population structureRace, Genetics, and Society

Geographic Patterns of Genome Admixture in Latin American Mestizos

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Wang, Sijia, Ray, Nicolas, Rojas, Winston, Parra, Maria V., Bedoya, Gabriel, Gallo, Carla, Poletti, Giovanni, Mazzotti, Guido +20 more·2008·PLoS Genetics
DOI 10.1371/journal.pgen.1000037PMC PMC2265669
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Abstract

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.

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  • Further stratification of individuals by self-reported population affiliation reveals a diversity in genetic ancestry, consistent with previous work studying these populations.

    “Further stratification of individuals by their self-reported population affiliation (e.g., “Mexican,” “Puerto Rican,” or “Dominican”) reveals a diversity in genetic ancestry, consistent with previous work studying these populations (see Figure S5 and Table S5).10,20,24,25,68,69”

    From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [20]

    The Results/Discussion reports substantial variation in ancestry across the Mestizo populations studied, including variation among individuals in Mexico City. But the Methods (Population Samples) says no ethnic identification was attempted at collection. The paper therefore supports diversity in genetic ancestry, not the specific claim that stratifying people by self-reported Mexican, Puerto Rican, or Dominican affiliation reveals it. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Individuals from countries across South America, the Caribbean, and Mexico have different profiles of genetic ancestry molded by each population's unique history and interactions with local Native American populations.

    “Individuals from countries across South America, the Caribbean, and Mexico have different profiles of genetic ancestry molded by each population’s unique history and interactions with local Native American populations.1,19–25”

    From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [20]

    The Results/Discussion (page not supplied) reports substantial variation in ancestry across sampled Mestizo populations and links it to regional history and nearby Native American populations. The paper does not establish this pattern for the Caribbean, which the claim also includes. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Wang, S., Ray, N., Rojas, W., Parra, M. V., Bedoya, G., Gallo, C., Poletti, G., Mazzotti, G., Hill, K., Hurtado, A. M., Camrena, B., Nicolini, H., Klitz, W., Barrantes, R., Molina, J. A., Freimer, N. B., Bortolini, M. C., Salzano, F. M., Petzl-Erler, M. L., Tsuneto, L. T., Dipierri, J. E., Alfaro, E. L., Bailliet, G., Bianchi, N. O., Llop, E., Rothhammer, F., Excoffier, L., & Ruiz-Linares, A.
Affiliations
  • University College London (GB)
  • University of Bern (CH)
  • Universidad de Antioquia (CO)
  • Universidad Peruana Cayetano Heredia (PE)
  • University of New Mexico (US)
  • Universidad Autónoma de la Ciudad de México (MX)
  • Public Health Institute (US)
  • Universidad de Costa Rica (CR)
  • University of California, Los Angeles (US)
  • Universidade Federal do Rio Grande do Sul (BR)
  • Universidade Federal do Paraná (BR)
  • National University of Jujuy (AR)
  • Instituto Multidisciplinario de Biología Celular (AR)
  • University of Chile (CL)
  • University of Tarapacá (CL)
ORCID
Venue
PLoS Genetics
Publisher
Public Library of Science (PLoS)
Published
2008-03-21
Volume
4
Issue
3
Pages
e1000037
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
DOI
10.1371/journal.pgen.1000037
PMC
PMC2265669
OpenAlex
W2047299569
Cited by
453
References
1
Citations by year
2026: 8 · 2025: 8 · 2024: 11 · 2023: 14 · 2022: 15 · 2021: 20 · 2020: 27 · 2019: 29 · 2018: 34 · 2017: 34 · 2016: 19 · 2015: 40 · 2014: 43 · 2013: 31 · 2012: 38
FWCI
15.62
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Genetics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • Americanae (AECID Library) (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Figshare (submittedVersion, cc-by)
  • Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, other-oa)
  • Universidad de Chile (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Science Foundation (1050595)
  • Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
  • Consejo Nacional de Investigaciones Científicas y Técnicas
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Universidad de Antioquia
  • National Institutes of Health (NIH-R01)
  • Agencia Nacional de Promoción Científica y Tecnológica (CONICET)
  • National Heart, Lung, and Blood Institute (NIH R01)
  • National Institute of Mental Health (R01MH049499)
  • National Institute of Neurological Disorders and Stroke (R01 NS37484, R01NS037484, R01NS043538)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
Keywords
population admixture, Native American ancestry, European ancestry, African ancestry, autosomal microsatellites, demographic history, admixture mapping
MeSH terms
Female, Genetics, Population, Heterozygote, Humans, Latin America, Male, Genetic Variation, Genome, Human, Microsatellite Repeats, Chromosomes, Human, X, Black People, White People, American Indian or Alaska Native

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