Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
Feng, Jian Q, Ward, Leanne M, Liu, Shiguang, Lu, Yongbo, Xie, Yixia, Yuan, Baozhi, Yu, Xijie, Rauch, Frank, Davis, Siobhan I, Zhang, Shubin, Rios, Hector, Drezner, Marc K, Quarles, L Darryl, Bonewald, Lynda F, White, Kenneth E·2006·Nature Genetics
DOI 10.1038/ng1905
Cited by (1,001)
Items 701–800 of 1,001
- Correlation of fgf23 and balp with bone mineral density in hemodialysis patientsMouna Bouksila, Mehdi Mrad, Wajih Kaabachi, Eya Kalai, Wided Smaoui, S. Rekik, Asma Krir, Nesrine Aissaoui, Kamel Hamzaoui, Héla Sahli et al. · 2019 · Journal of Medical Biochemistry
- Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesisHui Yi Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang et al. · 2019 · Frontiers of Medicine
- Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-cateninHui Li, Yan Jing, Rong Zhang, Qi Zhang, Jun Wang, Aline Martin, Jian Q. Feng · 2019 · Bone
- Methods for studying MLO-Y4 osteocytes in collagen-hydroxyapatite scaffolds in the rotary cell culture systemRoxanne Fournier, Rene E. Harrison · 2020 · Connective Tissue Research
- It ANKH Necessarily SoMichael Terrence Collins, Manfred Boehm · 2011 · The Journal of Clinical Endocrinology & Metabolism
- Osteosarcopenia: epidemiology, molecular mechanisms, and managementYong-Tao Yi, Hao-Fan Zhao, Weizhou Wang, Xi Li · 2025 · Frontiers in Endocrinology
- Shedding Light on the Complex Regulation of FGF23Marc G. Vervloet · 2022 · Metabolites
- Research perspectives: The 2013 AAOS/ORS research symposium on Bone Quality and Fracture PreventionEve L. Donnelly, Joseph M. Lane, Adele L. Boskey · 2014 · Journal of Orthopaedic Research®
- Recent Progress in Osteocyte ResearchPaola Divieti Pajevic · 2013 · Endocrinology and Metabolism
- CATCHing putative causative variants in consanguineous familiesFederico Andrea Santoni, Periklis Makrythanasis, Stylianos E. Antonarakis · 2015 · BMC Bioinformatics
- The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expressionJulia M. Hum, Erica L. Clinkenbeard, Colin S. Ip, Taryn A. Cass, Matthew R. Allen, Kenneth E. White · 2017 · Bone Reports
- Cellular Actions of PTHBarbara Campolina Carvalho Silva, Stavroula Kousteni · 2014 · Elsevier eBooks
- Validation of a next-generation sequencing (NGS) panel to improve the diagnosis of X-linked hypophosphataemia (XLH) and other genetic disorders of renal phosphate wastingSusanne Thiele, Ralf Werner, Annika Stubbe, Olaf Hiort, Wolfgang Hoeppner · 2020 · European Journal of Endocrinology
- A Practical Clinical Approach to Paediatric Phosphate DisordersErik Allen Imel, Thomas O. Carpenter · 2015 · Endocrine development
- Case Report: Hypophosphatemic rickets and aggressive periodontitis: a review of the role of dentine matrix protein 1 in the pathogenesisSuhad Hussein Al‐Jundi, Mohammad Hammad, I. M. DABOUS · 2011 · European Archives of Paediatric Dentistry
- SPR4-peptide alters bone metabolism of normal and HYP miceLesya V. Zelenchuk, Anne-Marie Hedge, Peter S. Rowe · 2014 · Bone
- What would we like to know, and what do we not know about fibroblast growth factor 23Mario Gennaro Cozzolino, Andrea Galassi, Mugurel Apetrii, Adrian Constantin Covic · 2011 · Journal of Nephrology
- The osteocyte—A novel endocrine regulator of body phosphate homeostasisFan Cheng, P A Hulley · 2010 · Maturitas
- High Mineralization Capacity of IDG-SW3 Cells in 3D Collagen Hydrogel for Bone Healing in Estrogen-Deficient MiceKaizhe Chen, Qi Zhou, Hui Kang, Yufei Yan, Niandong Qian, Changwei Li, Fei Wang, Kai Yang, Lianfu Deng, Qi Jin · 2020 · Frontiers in Bioengineering and Biotechnology
- Prostate cancer and bone: clinical presentation and molecular mechanismsKristina V Wells, Margaret Li Krackeler, Maitreyee K. Jathal, Mamta Parikh, P. Ghosh, Jonathan Kent Leach, Damian C. Genetos · 2023 · Endocrine Related Cancer
- Inherited phosphate and pyrophosphate disordersBrian Lee Foster, Alison M. Boyce, José Luís Millán, Kaitrin Kramer, Carlos R. Ferreira, Martha Joan Somerman, John Timothy Wright · 2024 · The Journal of the American Dental Association
- Constitutive Nuclear Expression of Dentin Matrix Protein 1 Fails to Rescue the Dmp1-null PhenotypeShuxian Lin, Qi Zhang, Zhengguo Cao, Yongbo Lu, Hua Zhang, Kevin Yan, Ying Liu, Marc D. McKee, Chunlin Qin, Zhi Chen et al. · 2014 · Journal of Biological Chemistry
- Biomimetic principle for development of nanocomposite biomaterials in tissue engineeringMehdi Ebrahimi · 2018 · Elsevier eBooks
- Molecular Control of Phosphorus Homeostasis and Precision Treatment of Hypophosphatemic DisordersThomas Joseph Weber, L. Darryl Quarles · 2019 · Current Molecular Biology Reports
- The identification of critical time windows of postnatal root elongation in response to Wnt/β‐catenin signalingJun Wang, Yong Jiang, Xudong Xie, Shiwen Zhang, Chunmei Xu, Yinghong Zhou, Jian Q. Feng · 2020 · Oral Diseases
- Fgfr1 deficiency in osteocytes leads to increased bone mass by enhancing Wnt/β-catenin signalingYubin Tang, Peng Yang, Min Young Jin, Shuo Huang, Hangang Chen, Lin Chen, Jing Yang, Nan Yao Su · 2023 · Bone
- Is fibroblast growth factor 23 a harbinger of mortality in CKD?Jason R. Stubbs, Steve Egwuonwu · 2011 · Pediatric Nephrology
- Imaging Resin-Cast Osteocyte Lacuno-Canalicular System at Bone-Bioactive Glass Interface by Scanning Electron MicroscopyAlejandro A. Gorustovich · 2010 · Microscopy and Microanalysis
- Mini-implants and miniplates generate sub-absolute and absolute anchorageAlberto Girelli Consolaro · 2014 · Dental Press Journal of Orthodontics
- Dentine matrix protein 1 (DMP-1) is a marker of bone formation and mineralisation in soft tissue tumoursY. Inagaki, Takeshi G. Kashima, Edward S. Hookway, Yasuhito Tanaka, Andrew Bassim Hassan, Udo C. T. Oppermann, Nick A. Athanasou · 2015 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse modelsJirko Kühnisch, Jong Seto, Claudia Lange, Sabine Stumpp, Karolina Kobus, Julia Grohmann, Florent Elefteriou, Peter Fratzl, Stefan Mundlos, Mateusz Kolanczyk · 2014 · Bone
- THE ENDOCRINE FUNCTION OF THE BONE TISSUETatiana A. Grebennikova, Zhanna E. Belaya, Цориев Тимур Тамерланович, Liudmila Y. Rozhinskaya, Galina Afanas'evna Mel'nichenko · 2015 · Osteoporosis and Bone Diseases
- Functional derivatives of human dentin matrix protein 1 modulate morphology of calcium carbonate crystalsAleksandra Porębska, Mirosława Różycka, Rafał Hołubowicz, Zbigniew Szewczuk, Andrzej Ożyhar, Piotr Dobryszycki · 2020 · The FASEB Journal
- Long‐Term Effects of Sglt2 Deletion on Bone and Mineral Metabolism in MiceClaire Gerber, Xueyan Wang, Valentin David, Susan E. Quaggin, Tamara Isakova, Aline Martin · 2021 · JBMR Plus
- Diffuse pain, hypophosphatemia, and a subcutaneous noduleChristine A. DeWitt, Michael Terrence Collins, Edward W. Cowen · 2007 · Journal of the American Academy of Dermatology
- Miniplates and mini-implants: bone remodeling as their biological foundationAlberto Girelli Consolaro · 2015 · Dental Press Journal of Orthodontics
- Postnatal Renal DevelopmentMichel G. Baum, Jyothsna Gattineni, Lisa M. Satlin · 2012 · Elsevier eBooks
- Redox‐Dependent Bone Alkaline Phosphatase Dysfunction Drives Part of the Complex Bone Phenotype in Mice Deficient for Memo1Matthias B. Moor, Suresh Krishna Ramakrishnan, Finola Legrand, Silvia Dolder, Mark Siegrist, Fanny Durussel, Gabriel Centeno, Dmitri Firsov, Nancy E. Hynes, Willy Hofstetter et al. · 2018 · JBMR Plus
- Genetics of Skeletal DisordersFadil M. Hannan, Paul J. Newey, Michael P. Whyte, Rajesh V. Thakker · 2020 · Handbook of experimental pharmacology
- Ortho-silicic Acid Plays a Protective Role in Glucocorticoid-Induced Osteoporosis via the Akt/Bad Signal Pathway In Vitro and In VivoGuanghui Gu, Dehui Hou, Guangjun Jiao, Wenliang Wu, Hongming Zhou, Hongliang Wang, Yunzhen Chen · 2022 · Biological Trace Element Research
- Tendon Cells Root Into (Instead of Attach to) Humeral Bone Head via Fibrocartilage-EnthesisZheng Wang, Chi Ma, Diane Chen, Caitlin Haslett, Chunmei Xu, Changchun Dong, Xiaofang Wang, Minghao Zheng, Yan Jing, Jian Q. Feng · 2022 · International Journal of Biological Sciences
- Osteocyte: a Cellular Basis for Mechanotransduction in BoneGuoliang Gu, K. Kurata, Zhi Chen, Kalervo Väänänen · 2007 · Journal of Biomechanical Science and Engineering
- Calcium Phosphate Surface Tailoring Technologies for Drug Delivering and Tissue Engineering2012 · BENTHAM SCIENCE PUBLISHERS eBooks
- Glycosaminoglycans and their sulfate derivatives differentially regulate the viability and gene expression of osteocyte-like cell linesElena A. Tsourdi, Juliane Salbach‐Hirsch, Martina Rauner, Tilman D. Rachner, Stephanie Möller, Matthias Schnabelrauch, Dieter Scharnweber, Lorenz Christian Hofbauer · 2014 · Journal of Bioactive and Compatible Polymers
- Transcriptome analysis of osteoblasts in an ovariectomized mouse model in response to physical exerciseW-B. Hsu, Wei‐Hsiu Hsu, Hung Js, W-J. Shen, Robert Wen‐Wei Hsu · 2018 · Bone and Joint Research
- Bone and heart health in chronic kidney diseaseAline Martin · 2019 · Current Opinion in Nephrology & Hypertension
- Recombinant Human Dentin Matrix Protein 1 (hDMP1) Expressed in Nicotiana benthamiana Potentially Induces Osteogenic DifferentiationAktsar Roskiana Ahmad, Pornjira Kaewpungsup, Narach Khorattanakulchai, Kaewta Rattanapisit, Prasit Pavasant, Waranyoo Phoolcharoen · 2019 · Plants
- Immunohistochemical expression of non-collagenous extracellular matrix molecules involved in tertiary dentinogenesis following direct pulp capping: a systematic reviewClaudiu Călin, Maria Sajin, Valentin Tiberiu Moldovan, Cristin Coman, Ştefan‐Ioan Stratul, Andreea Cristiana Didilescu · 2021 · Annals of Anatomy - Anatomischer Anzeiger
- Collagen Suprafibrillar Confinement Drives the Activity of Acidic Calcium-Binding Polymers on Apatite MineralizationJérémie Silvent, Marc Robin, Camila Bussola Tovani, Yan Wang, Fabrice Soncin, Sidney Delgado, Thierry Azaı̈s, Capucine Sassoye, Marie‐Madeleine Giraud‐Guille, Jean‐Yves Sire et al. · 2021 · Biomacromolecules
- Bone biopsy findings in patients receiving long-term bisphosphonate therapy for glucocorticoid-induced osteoporosisMasahiko Takahata, Tomohiro Shimizu, Satoshi Yamada, Tomomaya Yamamoto, Tomoka Hasegawa, Ryo Fujita, Hideyuki Kobayashi, Tsutomu Endo, Yoshinao Koike, Norio Amizuka et al. · 2022 · Journal of Bone and Mineral Metabolism
- Phosphate Is a Cardiovascular ToxinMaren Leifheit‐Nestler, Isabel Vogt, Dieter Haffner, Beatrice Richter · 2022 · Advances in experimental medicine and biology
- FGF23 as a novel therapeutic target.T. Shimada, S. Fukumoto · 2012 · Advances in Experimental Medicine and Biology
- Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in miceLing Chen, Hong Liu, Wen Sheng Sun, Xiuying Bai, Andrew C. Karaplis, David Goltzman, Dengshun Miao · 2011 · Clinical and Experimental Pharmacology and Physiology
- Untangling Klotho's Role in Calcium HomeostasisGordon J Strewler · 2007 · Cell Metabolism
- Tailored biomimetic hydrogel based on a photopolymerised DMP1/MCF/gelatin hybrid system for calvarial bone regenerationShuxian Lin, Lingyan Cao, Qian Wang, Jiahui Du, Delong Jiao, Sheng‐Zhong Duan, Jiannan Wu, Qi Gan, Xinquan Jiang · 2017 · Journal of Materials Chemistry B
- Nutritional RicketsJohn Morley Pettifor · 2011 · Elsevier eBooks
- Chapter 4. OsteocytesLynda Faye Bonewald · 2008 · Primer on the metabolic bone diseases and disorders of mineral metabolism
- Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemiaXiuqi Li, Larisa Lozovatsky, Steven M. Tommasini, Jackie A. Fretz, Karin E. Finberg · 2023 · Blood Advances
- Biology of bone mineralization and ectopic calcifications: the same actors for different playsMarie‐Hélène Lafage‐Proust, David Magne · 2024 · Archives de Pédiatrie
- Three Novel Mutations in the PHEX Gene in Chinese Subjects with Hypophosphatemic Rickets Extends Genotypic VariabilityTjin‐Shing Jap, Chih‐Yang Chiu, Dau‐Ming Niu, Michael A. Levine · 2011 · Calcified Tissue International
- Genetic diseases resulting from disordered FGF23/klotho biologyMichael J. Econs · 2016 · Bone
- Isolation, Purification, Generation, and Culture of OsteocytesJonathan H. Gooi, Ling Yeong Chia, Christina Vrahnas, Natalie A. Sims · 2019 · Methods in molecular biology
- Germline Saturation Mutagenesis Induces Skeletal Phenotypes in MiceJonathan J. Rios, Kristin Denton, Jamie L. Russell, Julia Kozlitina, Carlos R. Ferreira, Amy Feldman Lewanda, Joshua E. Mayfield, Eva Marie Y. Moresco, Sara M. Ludwig, Miao Tang et al. · 2020 · Journal of Bone and Mineral Research
- FGF23 tumor induced osteomalaciaSofia Gronskaia, Zhanna E. Belaya, Galina Afanas'evna Mel'nichenko · 2022 · Problems of Endocrinology
- Postnatal Bone Growth: Growth Plate Biology, Bone Formation, and RemodelingChrista Maes, Henry M. Kronenberg · 2011 · Elsevier eBooks
- Post-natal bone physiologyRania Ali El-Farrash, Radwa Hassan Ali, Noha M. Barakat · 2019 · Seminars in Fetal and Neonatal Medicine
- Recombinant human dentin matrix protein 1 (DMP1) induces the osteogenic differentiation of human periodontal ligament cellsAktsar Roskiana Ahmad, Pornjira Kaewpungsup, Narach Khorattanakulchai, Kaewta Rattanapisit, Prasit Pavasant, Waranyoo Phoolcharoen · 2019 · Biotechnology Reports
- The osteocyteJenneke Klein‐Nulend, Lynda Faye Bonewald · 2019 · Elsevier eBooks
- Hereditary hypophosphatemias: New genes in the bone–kidney axis (Review Article)Armando Luis Negri · 2007 · Nephrology
- Vitamin DDaniel D. Bikle, John S. Adams, Sylvia Christakos · 2018 · Primer on the metabolic bone diseases and disorders of mineral metabolism
- Mapping the Response of Human Osteocytes in Native Matrix to Mechanical Loading Using RNA SequencingChen Zhang, Huib W. van Essen, Daoud Sie, Dimitra Micha, Gerard Pals, Jenneke Klein‐Nulend, Nathalie Bravenboer · 2023 · JBMR Plus
- Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathwayNingyuan Sun, Huawei Zou, Liang Yang, Koji Morita, Ping Gong, Toshikazu Shiba, Yasumasa Akagawa, Quan Yuan · 2012 · Biochemical and Biophysical Research Communications
- ASARM mineralization hypothesis: A bridge too far?Valentin David, L. Darryl Quarles · 2010 · Journal of Bone and Mineral Research
- Differential osteogenicity of multiple donor-derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold-based 3D culture and in vivoVerena M.C. Quent, Christina Theodoropoulos, Dietmar Werner Hutmacher, Johannes Christian Reichert · 2015 · Biomedizinische Technik/Biomedical Engineering
- Paracrine and endocrine functions of osteocytesToshimi Michigami · 2022 · Clinical Pediatric Endocrinology
- Osteocyte BiologyLynda Faye Bonewald · 2013 · Elsevier eBooks
- Osteocytes in Normal Physiology and OsteoporosisKen Watanabe, Kyoji Ikeda · 2010 · Clinical Reviews in Bone and Mineral Metabolism
- The in vivo role of DMP-1 and serum phosphate on bone mineral compositionMegen Maginot, Shuxian Lin, Ying Liu, Baozhi Yuan, Jian Q. Feng, Pranesh B. Aswath · 2015 · Bone
- Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinomaShigeki Suzuki, Hiroaki Hoshino, Kazuma Yoshida, Jun Nakanishi, Shizu Tsuchiya-Hirata, Seiji Kobuke, Naoto Haruyama, Fusanori Nishimura, Hideki Shiba · 2017 · Biochemical and Biophysical Research Communications
- Alveolar bone remodeling after tooth extraction in irradiated mandible: An experimental study with canine modelVenni Heinonen, Timo J. Ruotsalainen, Lauri Paavola, Jopi J. W. Mikkonen, Pekka Asikainen, Arto P. Koistinen, Arja M. Kullaa · 2018 · Ultrastructural Pathology
- A novel de novo mosaic mutation in PHEX in a Korean patient with hypophosphatemic ricketsMisun Yang, Jinsup Kim, Aram Yang, Ja‐Hyun Jang, Tae Yeon Jeon, Sung Yoon Cho, Dong‐Kyu Jin · 2018 · Annals of Pediatric Endocrinology & Metabolism
- Decreased Trabecular Bone Mass in Col22a1-Deficient MiceWenbo Zhao, Philip Wiedemann, Eva Maria Wölfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Björn Busse, Michael Amling, Thorsten Schinke et al. · 2021 · Cells
- Solid Nomenclature: The Bedrock of Science. Similarities and Dissimilarities in Phenomena and Cells of Tooth and Bone OntogenyM. Larmas, George K.B. Sándor · 2013 · The Anatomical Record
- The skeleton: Endocrine regulator of phosphate homeostasisMaı̀re E. Doyle, Suzanne M. Jan de Beur · 2008 · Current Osteoporosis Reports
- The Roles of Osteocyte Signaling in BoneOran D. Kennedy, Mitchell B. Schaffler · 2012 · Journal of the American Academy of Orthopaedic Surgeons
- FGF23-Klotho axis in CKDYuichi Takashi, Seiji Fukumoto · 2016 · Renal Replacement Therapy
- OsteocytesLynda Faye Bonewald · 2013 · Primer on the metabolic bone diseases and disorders of mineral metabolism
- Bone or Tooth dentin: The TGF-β signaling is the keyChunmei Xu, Xudong Xie, Yafei Wu, Jun Wang, Jian Q. Feng · 2024 · International Journal of Biological Sciences
- Ferric carboxymaltose increases fracture risk in patients and reduces bone formation in mice with iron deficiency anemiaSonja Wagner, Marlene Panzer, Elke Pertler, Stefan Redl, Martina Saretto, Benedikt Schaefer, Lorenz Michael Pammer, Laura Obholzer, Maria Rosina Troppmair, Michael W. Hess et al. · 2026 · Blood
- Notch signalling in alveolar bone development and regeneration: A critical regulator for osteoblasts to osteocytes transitioningDonglin Cai, Jin Shao, Yin Xiao · 2026 · Dental Research
- Erythroid-produced intact FGF23 is a paracrine inhibitor of erythropoiesisGuillaume Courbon, Jane J. Thomas, Eduardo Jorge Duque, Dominik Kentrup, Jadeah Jeannine Spindler, William Semancheck, Emily Tracey, Douglas E. Vaughan, Wenhan Chang, John W.M. Creemers et al. · 2026 · Blood
- Nanoscale Imaging and Analysis of Bone PathologiesVictoria Garcia-Giner, Zexiang Han, Finn Giuliani, Alexandra E. Porter · 2021 · Applied Sciences
- Effects of tocotrienol on osteocyte-mediated phosphate metabolism in high-carbohydrate high-fat diet-induced osteoporotic ratsSok Kuan Wong, Nur Irdina Adlin Fikri, Karthikgeyan Munesveran, Nur Syaqeerah Nor Hisham, Shirley Hui Jin Lau, Kok‐Yong Chin, Nur Azlina Mohd Fahami, Qodriyah Haji Mohd Saad, Yusof Kamisah, Azman Abdullah et al. · 2022 · Journal of Functional Foods
- Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue EngineeringMari M. Sato, Furqan Ali Shah · 2023 · Calcified Tissue International
- Genetic Disorders of Calcium and Phosphate HomeostasisHarald Jüppner, Rajesh V. Thakker · 2008 · Elsevier eBooks
- A silicon cell cycle in a bacterial model of calcium phosphate mineralogenesisKathryn M. Linton, Charles Ross Tapping, David G. Adams, Duncan Howard Carter, Roger C. Shore, Jean E. Aaron · 2012 · Micron
- Emergence of the osteo-epigenome in bone biologyShigeaki Kato, Kazuki Inoue, Minyoung Youn · 2010 · IBMS BoneKEy
- The Bioactive Acidic Serine- and Aspartate-Rich Motif PeptideTomoko Minamizaki, Yuji Yoshiko · 2015 · Current Protein and Peptide Science
- Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null miceShuxian Lin, Qi Zhang, Hua Zhang, Kevin Yan, Leanne Marie Ward, Yongbo Lu, Jianquan Feng · 2014 · International Journal of Oral Science
- Embryonic stem cell-derived osteocytes are capable of responding to mechanical oscillatory hydrostatic pressureDevon Duron Ehnes, Feodor D. Price, Nigel G. Shrive, David A. Hart, Derrick E. Rancourt, Nicole I. zur Nieden · 2015 · Journal of Biomechanics