Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

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Items 301–400 of 521

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  3. Mdm4 supports DNA replication in a p53-independent fashion
    Kai Wohlberedt, Ina Klusmann, Polina K. Derevyanko, Kester Mo Henningsen, Josephine Ann Mun Yee Choo, Valentina Manzini, Anna Magerhans, Celeste Giansanti, Christine M. Eischen, Aart G. Jochemsen et al. · 2020 · Oncogene
  4. miRNA regulation is important for DNA damage repair and recognition in malignant pleural mesothelioma
    Fabian Dominik Mairinger, Robert Werner, Elena Flom, Jan Schmeller, Sabrina Borchert, Michael Wessolly, Jeremias Wohlschlaeger, Thomas Hager, Thomas Mairinger, Jens Kollmeier et al. · 2017 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  5. Mdm2 protein Expression is Strongly Associated with Survival in Malignant Pleural Mesothelioma
    Fabian Dominik Mairinger, Robert F. H. Walter, Saskia C. Ting, Claudia Vollbrecht, Jens Kollmeier, S Griff, Thomas Hager, Thomas Mairinger, Daniel Christian Christoph, Dirk Theegarten et al. · 2014 · Future Oncology
  6. Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx
    Zengxin Lu, Guohui Wan, Huarong Guo, Xinna Zhang, Xiongbin Lu · 2012 · Cellular Signalling
  7. Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo
    Elizabeth A. Slee, Barbara Benassi, Robert David Goldin, Shan Zhong, Indrika Ratnayaka, Giovanni Blandino, Xin Lü · 2010 · Proceedings of the National Academy of Sciences
  8. Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)
    Lohrum · 2010 · International Journal of Oncology
  9. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53
    Zijian Li, Yue Xiong · 2017 · Oncogene
  10. Regulation of MDM4
    Michael P. Markey · 2010 · Frontiers in bioscience
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    Bertha C. Elias, Aaron Michael Laine, Ze’ev A. Ronai · 2005 · Oncogene
  12. Guilty as CHARGED: p53's expanding role in disease
    Jeanine L. Van Nostrand, Laura Donatella Attardi · 2014 · Cell Cycle
  13. Developmental Acquisition of p53 Functions
    Sushil Kumar Jaiswal, Sonam Raj, Melvin Depamphilis · 2021 · Genes
  14. Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish
    Joy Shijia Chua, Hoe Peng Liew, Lin Guo, David Philip Lane · 2015 · Oncogene
  15. Tumor suppressor p53 and estrogen receptors in nuclear–mitochondrial communication
    Nadi T. Wickramasekera, Gokul M. Das · 2013 · Mitochondrion
  16. The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review
    Heng Jiang, Jing Luo, Hetian Lei · 2022 · Experimental Eye Research
  17. DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner
    Min Qi, Jianglin Zhang, Weiqi Zeng, Xiang Chen · 2013 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  18. Peptide Activators of the p53 Tumor Suppressor
    Changyou Zhan, Wuyuan Lu · 2011 · Current Pharmaceutical Design
  19. Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
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  21. HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis
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  22. Overexpression of Mdm2 and MdmX Fusion Proteins Alters p53 Mediated Transactivation, Ubiquitination, and Degradation
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  23. Tissue specificity and spatio-temporal dynamics of the p53 transcriptional program
    Vinod Pant, Chang Sun, Guillermina Lozano · 2023 · Cell Death and Differentiation
  24. Guardian of corpulence: a hypothesis on p53 signaling in the fat cell
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    Qingling Huang, Lihong Chen, Leixiang Yang, Xiaoling Xie, Lin Gan, John L. Cleveland, Jiandong Chen · 2018 · Proceedings of the National Academy of Sciences
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  28. The Potential of Targeting P53 and HSP90 Overcoming Acquired MAPKi-Resistant Melanoma
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  29. The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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  31. Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in cancer
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  37. Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy
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  38. Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample
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  41. Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer
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    Olga Egorova, Heather HC Lau, Kate McGraphery, Yi Sheng · 2020 · International Journal of Molecular Sciences
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    Alan Richard Clarke, Monica Hollstein · 2003 · Cell Death and Differentiation
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  48. Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4)
    Antonio Macchiarulo, Nicola Giacchè, Andrea Carotti, Fabiola Moretti, Roberto Pellicciari · 2011 · MedChemComm
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  52. Predicted Functions of MdmX in Fine-Tuning the Response of p53 to DNA Damage
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  53. The Central Role of Ribosomal Proteins in p53 Regulation
    Mikael S. Lindström · 2025 · Cancers
  54. Arrestins in Apoptosis
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  56. A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize
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  59. Daxx Functions Are p53-Independent In Vivo
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  61. MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells
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  66. A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation
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  68. Variations within 3′-UTR of MDM4 gene contribute to clinical outcomes of advanced non-small cell lung cancer patients following platinum-based chemotherapy
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