Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

Parant, John, Chavez-Reyes, Arturo, Little, Natalie A., Yan, Wen, Reinke, Valerie, Jochemsen, Aart G., Lozano, Guillermina·2001·Nature Genetics

Cited by (521)

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  3. C-Abl as a modulator of p53
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  5. Regulation of tissue‐ and stimulus‐specific cell fate decisions by p53 in vivo
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  6. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development
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  8. p53 regulation: Teamwork between RING domains of Mdm2 and MdmX
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  14. Regulation of MDM2 Stability After DNA Damage
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  15. Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-Genotoxic Stresses
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  16. Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding
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  19. Role of Mdm2 and Mdmx in DNA repair
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  20. Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression
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  21. Mdm2 as a chromatin modifier
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  23. DisruptingTP53 in mouse models of human cancers
    John M. Parant, Guillermina Lozano · 2003 · Human Mutation
  24. G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization
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  26. Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice
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  27. p73: A chiaroscuro gene in cancer
    Mirko Marabese, Faina Vikhanskaya, Massimo Broggini · 2007 · European Journal of Cancer
  28. Analysis of p53 Dependent Damage Response in Sperm-irradiated Mouse Embryos
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  29. Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2
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  31. Mdm proteins: critical regulators of embryogenesis and homoeostasis
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    Ban Xiong Tan, Hoe Peng Liew, Joy Shijia Chua, Farid John Ghadessy, Yaw Sing Tan, David Philip Lane, Cynthia R. Coffill · 2017 · Journal of Molecular Cell Biology
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    Kadakia, Madhavi, Brown, Thomas L, McGorry, Molly M, Berberich, Steven J · 2002 · Oncogene
  36. MDM4 (MDMX) and its Transcript Variants
    F. Mancini, Giusy Di Conza, Fabiola Moretti · 2009 · Current Genomics
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    Markey, M, Berberich, S J · 2008 · Oncogene
  40. MDM2 and MDMX in Cancer and Development
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  42. Mdm2: Open questions
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    H Magnussen, Syed Feroj Ahmed, Gary J Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden et al. · 2020 · Nature Communications
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  49. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo
    Geoffrey M. Wahl · 2006 · Cell Death and Differentiation
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    David Philip Lane · 2004 · Carcinogenesis
  51. The p53-Mdm2 Loop: A Critical Juncture of Stress Response
    Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt · 2014 · Sub-cellular biochemistry/Subcellular biochemistry
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    Xiang Yu Zhou, Bo Cao, Hua Lu · 2017 · Journal of Molecular Cell Biology
  53. Induction of Cullin 7 by DNA damage attenuates p53 function
    Peter Jung, Berlinda Verdoodt, Aaron Oakley Bailey, John R. Yates, Antje Menssen, Heiko Hermeking · 2007 · Proceedings of the National Academy of Sciences
  54. Widespread Overexpression of Epitope-Tagged Mdm4 Does Not Accelerate Tumor Formation <i>In Vi</i><i>vo</i>
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    Heather A. Steinman, Hayla K. Sluss, Arthur Sands, German Albert Pihan, Stephen N. Jones · 2004 · Oncogene
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    Matijasevic, Zdenka, Krzywicka-Racka, Anna, Sluder, Greenfield, Jones, Stephen N. · 2008 · Cell Cycle
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  63. Abnormal MDMX degradation in tumor cells due to ARF deficiency
    Li, X, Gilkes, D, Li, B, Cheng, Q, Pernazza, D, Lawrence, H, Lawrence, N, Chen, J · 2012 · Oncogene
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  65. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis
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  70. P53 licensed to kill? Operating the assassin
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