The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease
Open accessAbstract
Dendritic cells (DCs) are 'professional' antigen-presenting cells that are key in the regulation of immune responses. Here we characterize a unique subset of tolerogenic DCs that expressed the chemokine receptor CCR9 and migrated to the CCR9 ligand CCL25, a chemokine linked to the homing of T cells and DCs to the gut. CCR9+ DCs were of the plasmacytoid DC (pDC) lineage, had an immature phenotype and rapidly downregulated CCR9 in response to maturation-inducing pDC-restricted Toll-like receptor ligands. CCR9+ pDCs were potent inducers of regulatory T cell function and suppressed antigen-specific immune responses both in vitro and in vivo, including inhibiting acute graft-versus-host disease induced by allogeneic CD4+ donor T cells in irradiated recipients. Our results identify a highly immunosuppressive population of pDCs present in lymphoid tissues.
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Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422
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Yu, W., Freeland, D. M. H., & Nadeau, K. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.111 · Cited by 659
Swiecki, M., & Colonna, M. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00881.x · Cited by 397
Horst, A. K., Neumann, K., Diehl, L., & Tiegs, G. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.112 · Cited by 295
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Jahrsdörfer, B., Vollmer, A., Blackwell, S. E., Maier, J., Sontheimer, K., Beyer, T., Mandel, B., Lunov, O., Tron, K., Nienhaus, G. U., et al. (2010) · Blood · doi:10.1182/blood-2009-07-235382 · Cited by 180
Yun, T. J., Lee, J. S., Machmach, K., Shim, D., Choi, J., Wi, Y. J., Jang, H. S., Jung, I.-H., Kim, K., Yoon, W. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.010 · Cited by 116
Metadata
- Authors
- Hadeiba, H., Sato, T., Habtezion, A., Oderup, C., Pan, J., & Butcher, E. C.
- Venue
- Nature Immunology
- Published
- 2008-10-05
- Volume
- 9
- Issue
- 11
- Pages
- 1253-1260
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2063917748
- Cited by
- 302
- References
- 3
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Hadeiba, H., Sato, T., Habtezion, A., Oderup, C., Pan, J., & Butcher, E. C. (2008). CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nature Immunology. https://doi.org/10.1038/ni.1658
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