The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells
Open accessAbstract
The improved antibody responses of class-switched memory B cells depend on enhanced signaling from their B cell antigen receptors (BCRs). However, BCRs on both naive and antigen-experienced B cells use the canonical immunoglobulin-associated α and β-protein signaling subunits. Here we identified a BCR isotype–specific signal-amplification mechanism. Whereas immunoglobulin M (IgM)-containing BCRs initiated intracellular signals exclusively through immunoglobulin-associated α- and β-proteins, IgG- and IgE-containing BCRs also used a conserved tyrosine residue in the cytoplasmic segments of immunoglobulin heavy chains. When phosphorylated, this tyrosine recruited the adaptor Grb2, resulting in sustained protein kinase activation and prolonged generation of second messengers, which together culminated in enhanced B cell proliferation. Hence, membrane-bound IgG and IgE exert antigen recognition as well as costimulatory functions, thereby rendering memory B cells less dependent on T cell help.
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Cites
Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412
Suntharalingam, G., Perry, M. R., Ward, S., Brett, S. J., Castello-Cortes, A., Brunner, M. D., & Panoskaltsis, N. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa063842 · Cited by 2,164 · cited 1×
“The disastrous cytokine storm observed during a phase I clinical trial with the monoclonal CD28-specific antibody TGN1412 (ref”
BackgroundCD28-mediated co-stimulation: a quantitative support for TCR signalling.
Acuto, O., & Michel, F. (2003) · Nature Reviews Immunology · doi:10.1038/nri1248 · Cited by 775
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
Rolli, V., Gallwitz, M., Wossning, T., Flemming, A., Schamel, W. W. A., Zürn, C., & Reth, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00739-6 · Cited by 331
Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies
Waibler, Z., Sender, L. Y., Merten, C., Hartig, R., Kliche, S., Gunzer, M., Reichardt, P., Kalinke, U., & Schraven, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001708 · Cited by 79 · cited 1×
“33 ) has been attributed to the ability of this antibody to induce long-lasting Ca 2+ entry across the T cell membran”
Background
Cited by
Role of Bruton’s tyrosine kinase in B cells and malignancies
Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0779-z · Cited by 726
Molecular programming of B cell memory
McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3128 · Cited by 449
Pathogenesis of Human B Cell Lymphomas
Shaffer, A. L., Young, R. M., & Staudt, L. M. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075027 · Cited by 437
Liu, S., Zhang, H., Li, M., Hu, D., Li, C., Ge, B., Jin, B., & Fan, Z. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.141 · Cited by 342
Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling
Andreani, V., Ramamoorthy, S., Fässler, R., & Grosschedl, R. (2023) · Journal of Experimental Medicine · doi:10.1084/jem.20220342 · Cited by 18
Metadata
- Authors
- Engels, N., König, L. M., Heemann, C., Lutz, J., Tsubata, T., Griep, S., Schrader, V., & Wienands, J.
- Venue
- Nature Immunology
- Published
- 2009-08-09
- Volume
- 10
- Issue
- 9
- Pages
- 1018-1025
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1973406789
- Cited by
- 177
- References
- 4
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Engels, N., König, L. M., Heemann, C., Lutz, J., Tsubata, T., Griep, S., Schrader, V., & Wienands, J. (2009). Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells. Nature Immunology. https://doi.org/10.1038/ni.1764
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