Molecular programming of B cell memory

Follicular Helper CD4 T Cells (T _FH )

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Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

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Germinal Centers

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Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

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Bcl6 mediates the development of T follicular helper cells

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Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

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The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

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Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

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Mechanism and Regulation of Class Switch Recombination

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Molecular Mechanisms of Antibody Somatic Hypermutation

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Germinal-Center Organization and Cellular Dynamics

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Programming the magnitude and persistence of antibody responses with innate immunity

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ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

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Cytokine-secreting follicular T cells shape the antibody repertoire

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

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Imaging of Germinal Center Selection Events During Affinity Maturation

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

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The who, how and where of antigen presentation to B cells

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Antigen-specific memory B cell development.

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A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

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PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

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Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation

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PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

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SAP-controlled T–B cell interactions underlie germinal centre formation

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Multiple layers of B cell memory with different effector functions

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B Cells Acquire Particulate Antigen in a Macrophage-Rich Area at the Boundary between the Follicle and the Subcapsular Sinus of the Lymph Node

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Follicular Helper T Cells: Lineage and Location

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Two levels of protection for the B cell genome during somatic hypermutation

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Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

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Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells

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T-bet regulates IgG class switching and pathogenic autoantibody production

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Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

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In vivo imaging of germinal centres reveals a dynamic open structure

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

Fazilleau, N., McHeyzer‐Williams, L. J., Rosen, H., & McHeyzer‐Williams, M. G. (2009) · Nature Immunology · doi:10.1038/ni.1704 · Cited by 451 · see citing works

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

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TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

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A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

Schwickert, T. A., Victora, G. D., Fooksman, D., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., Dustin, M. L., & Nussenzweig, M. C. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102477 · Cited by 427 · see citing works

B Cell Ligand Discrimination Through a Spreading and Contraction Response

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Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

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Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

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High affinity germinal center B cells are actively selected into the plasma cell compartment

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EBI2 mediates B cell segregation between the outer and centre follicle

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IL-4–producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

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The Humoral Immune Response Is Initiated in Lymph Nodes by B Cells that Acquire Soluble Antigen Directly in the Follicles

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T follicular helper cells differentiate from Th2 cells in response to helminth antigens

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The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

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Memory B-cell persistence is independent of persisting immunizing antigen

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Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

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Role of BCR affinity in T cell–dependent antibody responses in vivo

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Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

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Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns

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The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

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The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

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Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells

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Batf coordinates multiple aspects of B and T cell function required for normal antibody responses

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Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

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XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

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HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

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Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

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Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory

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Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced

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Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature

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XBP‐1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

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Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells

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A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor

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Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation

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Lymphoid reservoirs of antigen-specific memory T helper cells

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Development and Migration of Plasma Cells in the Mouse Lymph Node

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Plasma cells negatively regulate the follicular helper T cell program

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Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors

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HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

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IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β

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Initial Clonal Expansion of Germinal Center B Cells Takes Place at the Perimeter of Follicles

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CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

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Intrinsic Properties of immunoglobulin IgG1 Isotype-Switched B Cell Receptors Promote Microclustering and the Initiation of Signaling

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14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination

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Mechanisms promoting translocations in editing and switching peripheral B cells

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Preferential localization of IgG memory B cells adjacent to contracted germinal centers

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B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

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NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

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