The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
Open accessAbstract
It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate.
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Cites
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Cited by
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
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Transcription factors: from enhancer binding to developmental control
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, A. S., Li, C. H., Zamudio, A. V., Sigova, A. A., Hannett, N. M., Day, D. S., Abraham, B. J., Cohen, M. A., Nabet, B., Buckley, D. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.008 · Cited by 992
Metadata
- Authors
- Lin, Y. C., Jhunjhunwala, S., Benner, C., Heinz, S., Welinder, E., Mansson, R., Sigvardsson, M., Hagman, J., Espinoza, C. A., Dutkowski, J., Ideker, T., Glass, C. K., & Murre, C.
- Venue
- Nature Immunology
- Published
- 2010-06-13
- Volume
- 11
- Issue
- 7
- Pages
- 635-643
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2166773843
- Cited by
- 503
- References
- 43
- FWCI
- 20.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, Y. C., Jhunjhunwala, S., Benner, C., Heinz, S., Welinder, E., Mansson, R., Sigvardsson, M., Hagman, J., Espinoza, C. A., Dutkowski, J., Ideker, T., Glass, C. K., & Murre, C. (2010). A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nature Immunology. https://doi.org/10.1038/ni.1891
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