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Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity

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GM-CSF producing autoreactive CD4+ T cells in type 1 diabetes

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Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist

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NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer

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IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis

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SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration

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PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment

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Control of T cell effector functions by miRNAs

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Granulocyte-macrophage colony-stimulating factor as a mediator of autoimmunity in multiple sclerosis

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SRC3 is a co-factor for RORγt in Th17 differentiation but not thymocyte development

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Noradrenaline modulates CD4+ T cell priming in rat experimental autoimmune encephalomyelitis: a role for the α1-adrenoceptor

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High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy

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The many-sided contributions of NF-κB to T-cell biology in health and disease

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Targeting tumour necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response

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Lipid metabolism: a central modulator of RORγt-mediated Th17 cell differentiation

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Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis

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Th17 Response in Uveitis: A Double-Edged Sword in Ocular Inflammation and Immune Regulation

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PI3K activity in dendritic cells exerts paradoxical effects during autoimmune inflammation

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Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice

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LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis

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Immune Cell Contributors to the Female Sex Bias in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

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Death Receptor 5–Targeted Depletion of Interleukin‐23–Producing Macrophages, Th17, and Th1/17 Associated With Defective Tyrosine Phosphatase in Mice and Patients With Rheumatoid Arthritis

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Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach

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B cell depletion changes the immune cell profile in multiple sclerosis patients: One-year report

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Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function

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Fatigue favors in vitro Th1 and Th17-like cell expansion and reduces corticoid sensitivity in MS patients.

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CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis.

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Activation of mucosal immunity as a novel therapeutic strategy for combating brucellosis

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Neuro-immune crosstalk in depressive symptoms of multiple sclerosis

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Induction of Passive EAE Using Myelin-Reactive CD4+ T Cells

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Regulatory T Cell Dysfunction Acquiesces to BTLA+ Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis

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High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis

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Expression of GM-CSF Is Regulated by Fli-1 Transcription Factor, a Potential Drug Target

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Committed Tc17 cells are phenotypically and functionally resistant to the effects of IL‐27

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The Axis of Tolerance

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Interaction between Th17 and central nervous system in multiple sclerosis

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Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis

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Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells

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Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity

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STAT1 signaling protects self-reactive T cells from control by innate cells during neuroinflammation

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Highlights of the advances in basic immunology in 2011

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Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody

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Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

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Peroxisome Proliferator–Activated Receptor-δ Acts within Peripheral Myeloid Cells to Limit Th Cell Priming during Experimental Autoimmune Encephalomyelitis

Drohomyrecky, P. C., Doroshenko, E. R., Akkermann, R., Moshkova, M., Yi, T. J., Zhao, F. L., Ahn, J. J., McGaha, T. L., Pahan, K., & Dunn, S. E. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801200 · Cited by 18

Association between Inflammatory Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in Persons Living with HIV and HIV-Uninfected Individuals

Qin, S., Vodovotz, L., Zamora, R., Fitzpatrick, M., Kessinger, C., Kingsley, L., McMahon, D., DeSensi, R., Leader, J., Crothers, K., et al. (2020) · Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002234 · Cited by 11

Modeling a complex disease: Multiple sclerosis—Update 2020

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IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells

Rasouli, J., Casella, G., Ishikawa, L. L. W., Thomé, R., Boehm, A., Ertel, A., Melo‐Silva, C. R., Mari, E. R., Porazzi, P., Zhang, W., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.679498 · Cited by 17

T hy1+ S ca1+ innate lymphoid cells infiltrate the CNS during autoimmune inflammation, but do not contribute to disease development

Mair, F., & Becher, B. (2013) · European Journal of Immunology · doi:10.1002/eji.201343653 · Cited by 17

T‐bet or not T‐bet: Taking the last bow on the autoimmunity stage

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Human Aquaporin 4281–300 Is the Immunodominant Linear Determinant in the Context of HLA-DRB1*03:01

Arellano, B., Hussain, R. Z., Zacharias, T., Yoon, J., David, C., Zein, S., Steinman, L., Forsthuber, T., Greenberg, B., Lambracht-Washington, D., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1300 · Cited by 16

Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production

Layman, A. A. K., Sprout, S. L., Phillips, D., & Oliver, P. M. (2017) · Scientific Reports · doi:10.1038/srep39649 · Cited by 17

Regulation of lymphocyte trafficking in central nervous system autoimmunity

Oukka, M., & Bettelli, E. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.008 · Cited by 19

P2Y6 Deficiency Enhances Dendritic Cell–Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis

Li, Z., He, C., Zhang, J., Zhang, H., Wei, H., Wu, S., & Jiang, W. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900916 · Cited by 16

SerpinB1 expression in Th17 cells depends on hypoxia-inducible factor 1-alpha

Hou, L., & Yuki, K. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106826 · Cited by 16

Roles of CSF2 as a modulator of inflammation during retinal degeneration

Saita, K., Moriuchi, Y., Iwagawa, T., Aihara, M., Takai, Y., Uchida, K., & Watanabe, S. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155996 · Cited by 15

ALCAM on human oligodendrocytes mediates CD4 T cell adhesion

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GM-CSF-neuroantigen fusion proteins reverse experimental autoimmune encephalomyelitis and mediate tolerogenic activity in adjuvant-primed environments: association with inflammation-dependent, inhibitory antigen presentation

Islam, S. M. T., Curtis, A. D., Taslim, N., Wilkinson, D., & Mannie, M. (2014) · Journal of Immunology · doi:10.4049/jimmunol.1303223 · Cited by 17

CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis

Hernández-Mir, G., & McGeachy, M. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173655 · Cited by 16

Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation

So, J.-B., Silver, P., Jittayasothorn, Y., Mattapallil, M., Chan, C.-C., Horai, R., & Caspi, R. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102507 · Cited by 18

Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity

Manivasagam, S., Williams, J. L., Vollmer, L. L., Bollman, B., Bartleson, J. M., Ai, S., Wu, G. F., & Klein, R. S. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101041 · Cited by 16

GM-CSF production by CD4+ T cells in MS patients: Regulation by regulatory T cells and vitamin D

Peelen, E., Muris, A., Damoiseaux, J. G. M. C., Knippenberg, S. A. M., Broens, K., Smolders, J., Tervaert, J.-W. C., Hupperts, R., & Thewissen, M. M. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.02.007 · Cited by 16

Cholera Toxin Directly Enhances IL-17A Production from Human CD4+ T Cells

Tsai, H., & Wu, R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301079 · Cited by 17

Severe exacerbation of relapsing-remitting multiple sclerosis after G-CSF therapy

Rust, H. M., Kühle, J., Kappos, L., & Derfuss, T. J. (2016) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000215 · Cited by 16

Cytokines: GM-CSF in focus

Papatriantafyllou, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri2996 · Cited by 17

RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis

Rus, V., Nguyen, V. Q., Tatomir, A., Lees, J. R., Mekala, A. P., Boodhoo, D., Tegla, C., Luzina, I. G., Antony, P. A., Cudrici, C. D., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602158 · Cited by 16

Dehydrodiconiferyl alcohol (DHCA) modulates the differentiation of Th17 and Th1 cells and suppresses experimental autoimmune encephalomyelitis

Lee, J.-H., Choi, J., Lee, W., Ko, K. R., & Kim, S. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.09.028 · Cited by 16

Decoupling the role of RORγt in the differentiation and effector function of T H 17 cells

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