Crosstalk in NF-κB Signaling Pathways
Abstract
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs. Consequently, NF-κB-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways. This intricate crosstalk is crucial to shaping the diverse biological functions of NF-κB into cell type- and context-specific responses.
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The relaxation response enhances genes associated with energy metabolism, mitochondrial function, insulin secretion, and telomere maintenance, while reducing those linked to inflammation and stress.
“RR enhances genes associated with energy metabolism, mitochondrial function, insulin secretion, and telomere maintenance, while reducing those linked to inflammation and stress [40,60,61].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [40]
Both novice and long-term practitioners of the relaxation response experience significant gene expression changes, with long-term practitioners showing greater effects.
“Research indicates that both novice and long-term practitioners of RR experience significant gene expression changes, with long-term practitioners showing greater effects.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [40]
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References 192 · Cited by 1,942
- Authors
- Oeckinghaus, A., Hayden, M. S., & Ghosh, S.
- Affiliations
- Columbia University (US)
- Corresponding author
- Ghosh, Sankar
- Venue
- Nature Immunology
- Published
- 2011-07-19
- Volume
- 12
- Issue
- 8
- Pages
- 695-708
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1822745879
- Cited by
- 1,942
- References
- 192
- Citations by year
- 2026: 84 · 2025: 158 · 2024: 165 · 2023: 145 · 2022: 134 · 2021: 146 · 2020: 119 · 2019: 103 · 2018: 110 · 2017: 135 · 2016: 146 · 2015: 140 · 2014: 116 · 2013: 145 · 2012: 82
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- NF-κB signaling, signaling crosstalk, transcription factors, immune regulation, stress response, apoptosis, cell differentiation, transcriptional regulation, cell type-specific responses
- MeSH terms
- Animals, Cell Communication, Humans, Signal Transduction, Transcriptional Activation, NF-kappa B
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