The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?
Open accessAbstract
The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1β (IL-1β) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation.
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Cites
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Cited by
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Self-citationNLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
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Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
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The inflammation highway: metabolism accelerates inflammatory traffic in obesity
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Inflammasomes in carcinogenesis and anticancer immune responses
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Metadata
- Authors
- Wen, H., Ting, J. P.-Y., & O'Neill, L. A. J.
- Venue
- Nature Immunology
- Published
- 2012-03-19
- Volume
- 13
- Issue
- 4
- Pages
- 352-357
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1593760300
- Cited by
- 457
- References
- 38
- FWCI
- 18.01
- Type
- journal article
- Language
- en
- Open access
- green
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