The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice
Open accessAbstract
Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Here we characterized human gut DC populations and defined their relationship to previously studied human and mouse DCs. CD103+Sirpα− DCs were related to human blood CD141+ DCs and to mouse intestinal CD103+CD11b− DCs and expressed markers of cross-presenting DCs. CD103+Sirpα+ DCs aligned with human blood CD1c+ DCs and mouse intestinal CD103+CD11b+ DCs and supported the induction of regulatory T cells. Both CD103+ DC subsets induced the TH17 subset of helper T cells, while CD103−Sirpα+ DCs induced the TH1 subset of helper T cells. Comparative analysis of transcriptomes revealed conserved transcriptional programs among CD103+ DC subsets and identified a selective role for the transcriptional repressors Bcl-6 and Blimp-1 in the specification of CD103+CD11b− DCs and intestinal CD103+CD11b+ DCs, respectively. Our results highlight evolutionarily conserved and divergent programming of intestinal DCs.
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Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606
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Metadata
- Authors
- Watchmaker, P. B., Lahl, K., Lee, M., Baumjohann, D., Morton, J., Kim, S. J., Zeng, R., Dent, A., Ansel, K. M., Diamond, B., Hadeiba, H., & Butcher, E. C.
- Venue
- Nature Immunology
- Published
- 2013-12-01
- Volume
- 15
- Issue
- 1
- Pages
- 98-108
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2029184793
- Cited by
- 266
- References
- 5
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Watchmaker, P. B., Lahl, K., Lee, M., Baumjohann, D., Morton, J., Kim, S. J., Zeng, R., Dent, A., Ansel, K. M., Diamond, B., Hadeiba, H., & Butcher, E. C. (2014). Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nature Immunology. https://doi.org/10.1038/ni.2768
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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