Human dendritic cell subsets: an update

Collin, Matthew; Bigley, Venetia

doi:10.1111/imm.12888

Cited by 1,301Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

Human dendritic cell subsets: an update

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Collin, Matthew, Bigley, Venetia·2018·Immunology

DOI 10.1111/imm.12888PMC PMC5904714

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Abstract

Dendritic cells (DC) are a class of bone-marrow-derived cells arising from lympho-myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity. This task requires a wide range of mechanisms and responses, which are divided between three major DC subsets: plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1) and myeloid/conventional DC2 (cDC2). Each DC subset develops under the control of a specific repertoire of transcription factors involving differential levels of IRF8 and IRF4 in collaboration with PU.1, ID2, E2-2, ZEB2, KLF4, IKZF1 and BATF3. DC haematopoiesis is conserved between mammalian species and is distinct from monocyte development. Although monocytes can differentiate into DC, especially during inflammation, most quiescent tissues contain significant resident populations of DC lineage cells. An extended range of surface markers facilitates the identification of specific DC subsets although it remains difficult to dissociate cDC2 from monocyte-derived DC in some settings. Recent studies based on an increasing level of resolution of phenotype and gene expression have identified pre-DC in human blood and heterogeneity among cDC2. These advances facilitate the integration of mouse and human immunology, support efforts to unravel human DC function in vivo and continue to present new translational opportunities to medicine.

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The three other proteins increased in abundance in TET2-CH were CD1C, CLEC4C and CD86.
“The three other proteins increased in abundance in TET2-CH were CD1C (a marker of conventional dendritic cells), CLEC4C (a marker of plasmacytoid dendritic cells) and CD86 (a marker of dendritic cells, monocytes and other antigen-presenting cells)51.”
From Rare variant associations with plasma protein levels in the UK Biobank (2023) · cites this paper as [51]
The cDC2 Phenotype and distribution section identifies CD1c as expressed by conventional dendritic cells, and the plasmacytoid dendritic cell Phenotype and distribution section explicitly lists CLEC4C as a marker. The copy does not substantiate the CD86 marker description (searched: CD86). The citation appears to support the marker descriptions, not the citing authors’ TET2-CH abundance finding. (LLM, conf=0.86)
Experimental — accuracy not yet measured
pDCs are characterized by a marked impairment of cytokine release in older people.
“pDCs are instead characterized by a marked impairment of cytokine release in older people (27, 29).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [27]

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Self‐renewal capacity of human epidermal Langerhans cells: observations made on a composite tissue allograft
Kanitakis, J., Morélon, E., Petruzzo, P., Badet, L., & Dubernard, J. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01146.x · Cited by 96 · see citing works
Ligation of E-cadherin on in vitro–generated immature Langerhans-type dendritic cells inhibits their maturation
Riedl, E., Stöckl, J., Majdic, O., Scheinecker, C., Knapp, W., & Strobl, H. (2000) · Blood · doi:10.1182/blood.v96.13.4276 · Cited by 95 · see citing works
Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate
Wu, X., Briseño, C. G., Grajales‐Reyes, G. E., Haldar, M., Iwata, A., Kretzer, N. M., Wumesh, K. C., Tussiwand, R., Higashi, Y., Murphy, T. L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611408114 · Cited by 93 · see citing works
Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes
Capucha, T., Mizraji, G., Segev, H., Blecher‐Gonen, R., Winter, D. R., Khalaileh, A., Tabib, Y., Attal, T., Nassar, M., Zelentsova, K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.017 · Cited by 92 · see citing works
Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells
Hutter, C., Kauer, M., Simonitsch‐Klupp, I., Jug, G., Schwentner, R., Leitner, J. M., Böck, P., Steinberger, P., Bauer, W. M., Carlesso, N., et al. (2012) · Blood · doi:10.1182/blood-2012-02-410241 · Cited by 92 · see citing works
Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells
Harman, A. N., Bye, C. R., Nasr, N., Sandgren, K. J., Kim, M., Mercier, S. K., Botting, R. A., Lewin, S. R., Cunningham, A. L., & Cameron, P. U. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200779 · Cited by 91 · see citing works
A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid‐based model
Kawamoto, H., Ikawa, T., Masuda, K., Wada, H., & Katsura, Y. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00959.x · Cited by 89 · see citing works
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non‐human primates
Li, J., Ahmet, F., Sullivan, L. C., Brööks, A. G., Kent, S. J., Rose, R. D., Salazar, A. Μ., Sousa, C. R. E., Shortman, K., Lahoud, M. H., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201445127 · Cited by 87 · see citing works
Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation
Bigley, V., Maisuria, S., Cytlak, U., Jardine, L., Care, M. A., Green, K., Gunawan, M., Milne, P., Dickinson, R. E., Wiscombe, S., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.044 · Cited by 84 · see citing works
CD300a/c regulate type I interferon and TNF-α secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands
Ju, X., Zenke, M., Hart, D. N. J., & Clark, G. J. (2008) · Blood · doi:10.1182/blood-2007-12-127951 · Cited by 82 · see citing works
Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
Cytlak, U., Resteu, A., Bogaert, D., Kuehn, H. S., Altmann, T., Gennery, A. R., Jackson, G. H., Kumánovics, A., Voelkerding, K. V., Prader, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02977-8 · Cited by 81 · see citing works
Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects
Eguíluz‐Gracia, I., Bosco, A., Dollner, R., Melum, G. R., Lexberg, M. H., Jones, A. C., Dheyauldeen, S. A., Holt, P. G., Bækkevold, E. S., & Jahnsen, F. L. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.025 · Cited by 80 · see citing works
Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes
Liao, C., Andrews, R., Wallace, L., Khan, M. W. A., Kift-Morgan, A. P., Topley, N., Fraser, D. J., & Taylor, P. R. (2017) · Kidney International · doi:10.1016/j.kint.2016.10.030 · Cited by 80 · see citing works
Human plasmacytoid dendritic cells elicit a Type I Interferon response by sensing DNA via the cGAS‐STING signaling pathway
Bode, C., Fox, M., Tewary, P., Steinhagen, A., Ellerkmann, R. K., Klinman, D., Baumgarten, G., Hornung, V., & Steinhagen, F. (2016) · European Journal of Immunology · doi:10.1002/eji.201546113 · Cited by 79 · see citing works
CD1c+ blood dendritic cells have Langerhans cell potential
Milne, P., Bigley, V., Gunawan, M., Haniffa, M. A., & Collin, M. P. (2014) · Blood · doi:10.1182/blood-2014-08-593582 · Cited by 77 · see citing works
A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets
Sittig, S. P., Bakdash, G., Weiden, J., Sköld, A. E., Tel, J., Figdor, C. G., de Vries, I. J. M., & Schreibelt, G. (2016) · Mediators of Inflammation · doi:10.1155/2016/3605643 · Cited by 77 · see citing works
Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors
Helft, J., Anjos‐Afonso, F., van der Veen, A. G., Chakravarty, P., Bonnet, D. A., & Sousa, C. R. E. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.075 · Cited by 77 · see citing works
A thymic stromal lymphopoietin–responsive dendritic cell subset mediates allergic responses in the upper airway mucosa
Melum, G. R., Farkas, L., Scheel, C., van Dieren, B., Gran, E., Liu, Y.-J., Johansen, F., Jahnsen, F. L., & Bækkevold, E. S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.010 · Cited by 76 · see citing works
Innate IFNs and Plasmacytoid Dendritic Cells Constrain Th2 Cytokine Responses to Rhinovirus: A Regulatory Mechanism with Relevance to Asthma
Pritchard, A. L., Carroll, M. L., Burel, J. G., White, O. J., Phipps, S., & Upham, J. W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103507 · Cited by 76 · see citing works
Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β
Martínez-Cingolani, C., Grandclaudon, M., Jeanmougin, M., Jouve, M. J., Zollinger, R., & Soumelis, V. (2014) · Blood · doi:10.1182/blood-2014-04-568311 · Cited by 75 · see citing works
A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes
Hoshino, N., Katayama, N., Shibasaki, T., Ohishi, K., Nishioka, J., Masuya, M., Miyahara, Y., Hayashida, M., Shimomura, D., Kato, T., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204746 · Cited by 71 · see citing works
TLR Ligand-Dependent Activation of Naive CD4 T Cells by Plasmacytoid Dendritic Cells Is Impaired in Hepatitis C Virus Infection
Yonkers, N. L., Rodriguez, B. A., Milkovich, K. A., Asaad, R. J., Lederman, M. M., Heeger, P. S., & Anthony, D. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4436 · Cited by 71 · see citing works
Breast Cancer Cell–Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes
Ghirelli, C., Reyal, F., Jeanmougin, M., Zollinger, R., Sirven, P., Michea, P., Caux, C., Bendriss‐Vermare, N., Donnadieu, M., Caly, M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2386 · Cited by 67 · see citing works
Rapid Accumulation of CD14+CD11c+ Dendritic Cells in Gut Mucosa of Celiac Disease after in vivo Gluten Challenge
Beitnes, A.-C. R., Ráki, M., Brottveit, M., Lundin, K. E. A., Jahnsen, F. L., & Sollid, L. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033556 · Cited by 67 · see citing works
ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2
Ghosh, H. S., Ceribelli, M., de Matos, I. G., Lazarovici, A., Bussemaker, H. J., Lasorella, A., Hiebert, S. W., Liu, K., Staudt, L. M., & Reizis, B. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20132121 · Cited by 65 · see citing works
Dendritic Cells and Monocytes with Distinct Inflammatory Responses Reside in Lung Mucosa of Healthy Humans
Baharom, F., Thomas, S., Rankin, G. D., Lepzien, R., Pourazar, J., Behndig, A., Ahlm, C., Blomberg, A., & Smed‐Sörensen, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600071 · Cited by 65 · see citing works
Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets
Patel, V. I., Booth, J. L., Duggan, E. S., Cate, S. J., White, V. L., Hutchings, D., Kovats, S., Burian, D. M., Dozmorov, M. G., & Metcalf, J. P. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600777 · Cited by 65 · see citing works
Heterogeneity of Dendritic Cells in Human Superficial Lymph Node
Takahashi, K., Asagoe, K., Zaishun, J., Yanai, H., Yoshino, T., Hayashi, K., & Akagi, T. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65618-0 · Cited by 60 · see citing works
Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons
Bruni, D., Chazal, M., Sinigaglia, L., Chauveau, L., Schwartz, O., Desprès, P., & Jouvenet, N. (2015) · Science Signaling · doi:10.1126/scisignal.aaa1552 · Cited by 60 · see citing works
Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets
Geginat, J., Nizzoli, G., Paroni, M., Maglie, S., Larghi, P., Pascolo, S., & Abrignani, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00527 · Cited by 59 · see citing works
S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification
Teijaro, J. R., Studer, S., Leaf, N. B., Kiosses, W. B., Nguyen, N., Matsuki, K., Negishi, H., Taniguchi, T., Oldstone, M. B. A., & Rosen, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525356113 · Cited by 59 · see citing works
Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1+ DCs in mouse and human and distinguishes them from Langerhans cells
Carpentier, S., Manh, T. V., Chelbi, R., Henri, S., MALISSEN, B., Haniffa, M. A., Ginhoux, F., & Dalod, M. (2016) · Journal of Immunological Methods · doi:10.1016/j.jim.2016.02.023 · Cited by 58 · see citing works
IL‐10 promotes homeostatic proliferation of human CD8 + memory T cells and, when produced by CD1c + DCs, shapes naive CD8 + T‐cell priming
Nizzoli, G., Larghi, P., Paroni, M., Crosti, M., Moro, M., Neddermann, P., Caprioli, F., Pagani, M., Francesco, R. D., Abrignani, S., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546136 · Cited by 55 · see citing works
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: Rescue of severe herpetic infections with IFN-α 2b therapy
Keleş, S., Jabara, H. H., Reisli, İ., McDonald, D. R., Barlan, I. B., Hanna‐Wakim, R., Dbaibo, G. S., Lefranc, G., Al–Herz, W., Geha, R. S., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.032 · Cited by 53 · see citing works
GATA2 regulates dendritic cell differentiation
Onodera, K., Fujiwara, T., Onishi, Y., Itoh‐Nakadai, A., Okitsu, Y., Fukuhara, N., Ishizawa, K., Shimizu, R., Yamamoto, M. P., & Harigae, H. (2016) · Blood · doi:10.1182/blood-2016-02-698118 · Cited by 53 · see citing works
Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1
Romano, E., Cotari, J. W., da Silva, R. B., Betts, B. C., Chung, D. J., Avogadri, F., Fink, M. J., Angelo, E. T. S., Mehrara, B. J., Heller, G., et al. (2012) · Blood · doi:10.1182/blood-2011-09-382200 · Cited by 52 · see citing works
Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells
Artyomov, M. N., Munk, A., Gorvel, L., Korenfeld, D., Cella, M., Tung, T., & Klechevsky, E. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20131675 · Cited by 49 · see citing works
Transcriptional Regulation of Mononuclear Phagocyte Development
Tussiwand, R., & Gautier, E. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00533 · Cited by 48 · see citing works
CD1a, CD1b, and CD1c in Immunity Against Mycobacteria
Rhijn, I. V., Ly, D., & Moody, D. B. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6111-1_10 · Cited by 45 · see citing works
A CD2 high‐expressing stress‐resistant human plasmacytoid dendritic‐cell subset
Bryant, C. E., Fromm, P. D., Kupresanin, F., Clark, G. J., Lee, K. M. L., Clarke, C. J., Silveira, P. A., Suen, H., Brown, R. D., Newman, E., et al. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2015.116 · Cited by 45 · see citing works
The clash of Langerhans cell homeostasis in skin: Should I stay or should I go?
Hieronymus, T., Zenke, M., Baek, J.-H., & Seré, K. M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.02.009 · Cited by 44 · see citing works
S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells
Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Fink, A. F., Roberts, E., Brüne, B., & Weigert, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1403168 · Cited by 44 · see citing works
β-Catenin Signaling Drives Differentiation and Proinflammatory Function of IRF8-Dependent Dendritic Cells
Cohen, S. B., Smith, N. L., McDougal, C. E., Pepper, M., Shah, S. M., Yap, G. S., Acha‐Orbea, H., Jiang, A., Clausen, B. E., Rudd, B. D., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402453 · Cited by 42 · see citing works
Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms
Briseño, C. G., Gargaro, M., Durai, V., Davidson, J. T., Theisen, D. J., Anderson, D. A., Novack, D. V., Murphy, T. L., & MURPHY, K. M. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619863114 · Cited by 42 · see citing works
IFN- production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases
Berggren, O., Alexsson, A., Morris, D. L., Tandre, K., Weber, G., Vyse, T. J., Syvänen, A.-C., Rönnblom, L., & Eloranta, M. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv095 · Cited by 41 · see citing works
Langerhans Cell Homeostasis and Turnover After Nonmyeloablative and Myeloablative Allogeneic Hematopoietic Cell Transplantation
Mielcarek, M. B., Kirkorian, A. Y., Hackman, R. C., Price, J. G., Storer, B. E., Wood, B. L., Leboeuf, M., Bogunovic, M., Storb, R. F., Inamoto, Y., et al. (2014) · Transplantation · doi:10.1097/tp.0000000000000097 · Cited by 38 · see citing works
Characterisation of Leukocytes in a Human Skin Blister Model of Acute Inflammation and Resolution
Jenner, W. J., Motwani, M. P., Veighey, K. V., Newson, J., Audzevich, T., Nicolaou, A., Murphy, S., MacAllister, R. J., & Gilroy, D. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089375 · Cited by 37 · see citing works
Rapid Detection of Dendritic Cell and Monocyte Disorders Using CD4 as a Lineage Marker of the Human Peripheral Blood Antigen-Presenting Cell Compartment
Jardine, L., Barge, D., Ames-Draycott, A., Pagan, S., Cookson, S., Spickett, G., Haniffa, M. A., Collin, M. P., & Bigley, V. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00495 · Cited by 37 · see citing works
β-Catenin Promotes the Differentiation of Epidermal Langerhans Dendritic Cells
Yasmin, N., Konradi, S., Eisenwort, G., Schichl, Y. M., Seyerl, M., BAUER, T. L., Stöckl, J., & Strobl, H. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.481 · Cited by 36 · see citing works
Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells
van Leeuwen-Kerkhoff, N., Lundberg, K., Westers, T. M., Kordasti, S. Y., Bontkes, H. J., de Gruijl, T. D., Lindstedt, M., & van de Loosdrecht, A. A. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ma0117-037r · Cited by 36 · see citing works
Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset
Yu, H., Zhang, P., Yin, X., Yin, Z., Shi, Q., Cui, Y., Liu, G., Wang, S., Piccaluga, P. P., Jiang, T., et al. (2015) · Protein & Cell · doi:10.1007/s13238-015-0140-x · Cited by 34 · see citing works
CD1c-Expression by Monocytes – Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
Schrøder, M., Melum, G. R., Landsverk, O. J. B., Bujko, A., Yaqub, S., Gran, E., Aamodt, H., Bækkevold, E. S., Jahnsen, F. L., & Richter, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157387 · Cited by 34 · see citing works
CD1c-Related DCs that Express CD207/Langerin, but Are Distinguishable from Langerhans Cells, Are Consistently Present in Human Tonsils
Monte, A. D., Olivieri, C.-V., Vitale, S., Bailleux, S., Castillo, L., Giordanengo, V., Maryanski, J. L., Segura, É., & Doglio, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00197 · Cited by 33 · see citing works
Human dendritic cell subset 4 (DC4) correlates to a subset of CD14dim/−CD16++ monocytes
Calzetti, F., Tamassia, N., Micheletti, A., Finotti, G., Bianchetto-Aguilera, F. M., & Cassatella, M. A. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.12.988 · Cited by 33 · see citing works
Human embryonic epidermis contains a diverse Langerhans cell precursor pool
Schuster, C., Mildner, M., Mairhofer, M., Bauer, W. M., Fiala, C., Prior, M., Eppel, W., Kolbus, A., Tschachler, E., Stingl, G., et al. (2014) · Development · doi:10.1242/dev.102699 · Cited by 32 · see citing works
TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations
Colletti, N. J., Liu, H., Gower, A. C., Alekseyev, Y. O., Arendt, C., & Shaw, M. H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00088 · Cited by 30 · see citing works
Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation
Jurkin, J., Krump, C., Köffel, R., Fieber, C., Schuster, C., Brunner, P. M., Borek, I., Eisenwort, G., Lim, C. X., Mages, J., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.018 · Cited by 30 · see citing works
Characterization of CD56+ Dendritic-Like Cells: A Normal Counterpart of Blastic Plasmacytoid Dendritic Cell Neoplasm?
Osaki, Y., Yokohama, A., Saito, A., Tahara, K., Yanagisawa, K., Ogawa, Y., Ishizaki, T., Mitsui, T., Koiso, H., Takizawa, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081722 · Cited by 19 · see citing works
A multi‐laboratory comparison of blood dendritic cell populations
Fromm, P. D., Kupresanin, F., Brooks, A. E. S., Dunbar, P. R., Haniffa, M., Hart, D. N. J., & Clark, G. J. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.5 · Cited by 19 · see citing works
Profiling of primary peripheral blood‐ and monocyte‐derived dendritic cells using monoclonal antibodies from the HLDA10 Workshop in Wollongong, Australia
Autenrieth, S. E., Grimm, S., Rittig, S. M., Grünebach, F., Gouttefangeas, C., & Bühring, H. (2015) · Clinical & Translational Immunology · doi:10.1038/cti.2015.29 · Cited by 18 · see citing works
Short Communication: Plasmacytoid Dendritic Cells from HIV-1 Elite Controllers Maintain a Gut-Homing Phenotype Associated with Immune Activation
Li, H., Goepfert, P., & Reeves, R. K. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0174 · Cited by 13 · see citing works

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Sorted by citations

The Tumor Microenvironment Innately Modulates Cancer Progression
Hinshaw, D. C., & Shevde, L. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3962 · Cited by 3,270 · see citing works
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
Zhang, Y., & Zhang, Z. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0488-6 · Cited by 2,815 · see citing works
Dendritic cells in cancer immunology and immunotherapy
Wculek, S. K., Cueto, F. J., Mujal, A. M., Melero, I., Krummel, M. F., & Sancho, D. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0210-z · Cited by 2,594 · see citing works
Macrophage Polarization in Physiological and Pathological Pregnancy
Yao, Y., Xu, X.-H., & Jin, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00792 · Cited by 825 · see citing works
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer
Bassez, A., Vos, H., Van Dyck, L., Floris, G., Arijs, I., Desmedt, C., Boeckx, B., Vanden Bempt, M., Nevelsteen, I., Lambein, K., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01323-8 · Cited by 867 · see citing works
Dendritic Cells Revisited
Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M., & Reis e Sousa, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053707 · Cited by 757 · see citing works
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
“DCs, the most potent antigen presenting cells (APCs), can be divided into three subsets according to the expression of various markers (CD123, CD1c, CD141), one subset of plasmacytoid DCs (pDCs) and two subsets of myeloid DCs (mDCs) (27).”
Background
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma
Bi, K., He, M. X., Bakouny, Z., Kanodia, A., Napolitano, S., Wu, J., Grimaldi, G., Braun, D. A., Cuoco, M. S., Mayorga, A., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.02.015 · Cited by 613 · see citing works
“We extracted myeloid cells identified from the full dataset based onmarker expression and sub-clustered them, identifying two clusters of dendritic cells (CLEC9A and CD1c classical dendritic cells), two clusters of monocytes (classical CD16 and CD16 monocytes), and five clusters of TAMs, which expressed a diverse host…”
Influential
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics
Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 590 · see citing works
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer
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Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets
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“cDCs stimulated the Th-2, Th-17, and T regulatory responses [76].”
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Engineering dendritic cell vaccines to improve cancer immunotherapy
Perez, C. R., & Palma, M. D. (2019) · Nature Communications · doi:10.1038/s41467-019-13368-y · Cited by 507 · see citing works
Skin barrier immunity and ageing
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Dendritic Cells and Their Role in Immunotherapy
Gardner, A., Pulido, Á. D. M., & Ruffell, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00924 · Cited by 485 · see citing works
Obesity, Inflammation, and Immune System in Osteoarthritis
Nedunchezhiyan, U., Varughese, I., Sun, A. R., Wu, X., Crawford, R., & Prasadam, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907750 · Cited by 487 · see citing works
Beyond immune checkpoint blockade: emerging immunological strategies
Kubli, S. P., Berger, T., Araújo, D. V., Siu, L. L., & Mak, T. W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00155-y · Cited by 460 · see citing works
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
Hornburg, M., Desbois, M., Lu, S., Guan, Y., Lo, A. A., Kaufman, S., Elrod, A. K., Lotstein, A., DesRochers, T. M., Muñoz-Rodríguez, J. L., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.04.004 · Cited by 391 · see citing works
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
Kuo, C., Babuharisankar, A. P., Lin, Y.-C., Lien, H.-W., Lo, Y.-K., Chou, H.-Y., Tangeda, V., Cheng, L.-C., Cheng, A., & Lee, A. (2022) · Journal of Biomedical Sciences · doi:10.1186/s12929-022-00859-2 · Cited by 316 · see citing works
“Another group of immune cells that initiate and control immune responses are DCs that can be differentiated from monocytes during inflammation [189].”
Background
Dendritic cell subsets and locations
Balan, S., Saxena, M., & Bhardwaj, N. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.07.004 · Cited by 348 · see citing works
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy
Basu, A. B., Ramamoorthi, G., Albert, G. K., Gallen, C., Beyer, A., Snyder, C., Koski, G. K., Disis, M. L., Czerniecki, B. J., & Kodumudi, K. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669474 · Cited by 318 · see citing works
“This is in line with observations demonstrating that cDC2 are better equipped for CD4+ T cell differentiation due to preferential expression of MHC-II (64, 72, 73).”
BackgroundResultInfluential
Genetic models of human and mouse dendritic cell development and function
Anderson, D. A., Dutertre, C., Ginhoux, F., & MURPHY, K. M. M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00413-x · Cited by 314 · see citing works
Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases
Guo, R., Li, L., Su, J., Li, S., Duncan, S. E., Liu, Z., & Fan, G. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s266911 · Cited by 311 · see citing works
Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy
Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works
Antitumour dendritic cell vaccination in a priming and boosting approach
Harari, A., Graciotti, M., Bassani‐Sternberg, M., & Kandalaft, L. E. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0074-8 · Cited by 271 · see citing works
Advances on immunotherapy for osteosarcoma
Yu, S., & Yao, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02105-9 · Cited by 270 · see citing works
“DCs DCs, as professional antigen-presenting cells (APCs), act crucial roles between innate and adaptive immunity [59].”
Background
Unravelling the Interplay between Extracellular Acidosis and Immune Cells
Díaz, F. A. E., Dantas, E., & Geffner, J. R. (2018) · Mediators of Inflammation · doi:10.1155/2018/1218297 · Cited by 273 · see citing works
“DCs do not represent a homogeneous cell population; rather, different functionally specialized subsets of DCs exist, and each of them displays phenotypic and functional plasticity in response to diverse stimuli [101].”
Background
Estrogen Receptor Signaling in the Immune System
Chakraborty, B., Byemerwa, J. K., Krebs, T., Lim, F., Chang, C., & McDonnell, D. P. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac017 · Cited by 275 · see citing works
Antigen Cross-Presentation by Macrophages
Muntjewerff, E. M., Meesters, L. D., & van den Bogaart, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01276 · Cited by 262 · see citing works
“, interferon γ (IFN-γ)] and express proinflammatory cytokines, IL-6, tumor necrosis factor α (TNF-α), IL-1β, and inducible nitric oxide synthase (6, 11).”
Influential
Human dendritic cells in cancer
Kvedaraite, E., & Ginhoux, F. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm9409 · Cited by 261 · see citing works
Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
Kiaie, S. H., Zolbanin, N. M., Ahmadi, A., Bagherifar, R., Valizadeh, H., Kashanchi, F., & Jafari, R. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01478-7 · Cited by 261 · see citing works
Differential IRF8 Requirement Defines Two Pathways of Dendritic Cell Development in Humans
Cytlak, U., Resteu, A., Pagan, S., Green, K., Milne, P., Maisuria, S., McDonald, D., Hulme, G., Filby, A. J., Carpenter, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2020.07.003 · Cited by 250 · see citing works
“The hematopoiesis of dendritic cells (DCs) is controlled by a network of transcription factors (TFs), including GATA2, SPI1 (PU.1), TCF4 (E2-2), ZEB2, IRF4, IRF8, and IKZF1 (IKAROS) (Murphy et al., 2016; Collin and Bigley, 2018).”
The Role of the Immune Microenvironment in Bone Regeneration
Yang, N., & Liu, Y. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.61080 · Cited by 244 · see citing works
“Major histocompatibility complex II (MHC II) are highly expressed on the surface of DC membranes, which effectively activates the immune function of T cells and initiates the immune response [37].”
Background
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Tian, H., Cao, J., Li, B., Nice, E. C., Mao, H., Zhang, Y., & Huang, C. (2023) · Bone Research · doi:10.1038/s41413-023-00246-z · Cited by 239 · see citing works
Abdominal Aortic Aneurysm: Roles of Inflammatory Cells
Yuan, Z., Lü, Y., Wei, J., Wu, J., Yang, J., & Cai, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609161 · Cited by 232 · see citing works
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Junker, F., Gordon, J., & Qureshi, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01393 · Cited by 219 · see citing works
“DCs can broadly be grouped into three subsets in both mouse and human (8, 9): Plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1), and myeloid/conventional DC2 (cDC2).”
Background
An entropy-based metric for assessing the purity of single cell populations
Liu, B., Li, C., Li, Z., Wang, D., Ren, X., & Zhang, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-16904-3 · Cited by 213 · see citing works
“Specially, tumor-in ﬁ ltrating DC2 cells have been proven to be highly heterogeneous populations 29,30 and deviated substantially from the other homogeneous cell types including DC1, LAMP3 + DC, and pDC (Fig.”
Background
Single-cell and spatial transcriptomics analysis of non-small cell lung cancer
Zuani, M. D., Xue, H., Park, J. S., Dentro, S. C., Seferbekova, Z., Tessier, J., Curras-Alonso, S., Hadjipanayis, A. G., Athanasiadis, E. I., Gerstung, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48700-8 · Cited by 229 · see citing works
“This is consistent with the monocytic origin of mo-DC2s under in ﬂ ammatory conditions 23 .”
Phagocytic microglia and macrophages in brain injury and repair
Yu, F., Wang, Y., Stetler, R. A., Leak, R. K., Hu, X., & Chen, J. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13899 · Cited by 209 · see citing works
The Multiple Roles of Interferon Regulatory Factor family in Health and Disease
Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178 · see citing works
Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry
Brummelman, J., Haftmann, C., Núñez, N. G., Alvisi, G., Mazza, E. M. C., Becher, B., & Lugli, E. (2019) · Nature Protocols · doi:10.1038/s41596-019-0166-2 · Cited by 196 · see citing works
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
Wang, W., Xu, Y., Wang, L., Zhu, Z., Aodeng, S., Chen, H., Cai, M., Huang, Z., Han, J., Wang, L., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01312-0 · Cited by 195 · see citing works
Rare variant associations with plasma protein levels in the UK Biobank
Dhindsa, R. S., Burren, O. S., Sun, B. B., Prins, B. P., Matelska, D., Wheeler, E., Mitchell, J., Oerton, E., Hristova, V. A., Smith, K. R., et al. (2023) · Nature · doi:10.1038/s41586-023-06547-x · Cited by 193 · see citing works
“These two papers are highly complementary and we better outline these differences in lines 96-102.”
Background
Mucosal immune response in biology, disease prevention and treatment
Zhou, X., Wu, Y., Zhu, Z., Lu, C., Zhang, C., Zeng, L., Xie, F., Zhang, L., & Zhou, F. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02043-4 · Cited by 217 · see citing works
Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations
Xiong, P., Huang, X., Ye, N., Lu, Q., Zhang, G., Peng, S., Wang, H., & Liu, Y. (2022) · Advanced Science · doi:10.1002/advs.202106049 · Cited by 188 · see citing works
Macrophages: shapes and functions
Lendeckel, U., Venz, S., & Wolke, C. (2022) · ChemTexts · doi:10.1007/s40828-022-00163-4 · Cited by 185 · see citing works
Clinical and immunological effects of mRNA vaccines in malignant diseases
Heine, A., Juranek, S., & Brossart, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01339-1 · Cited by 185 · see citing works
“DCs are a highly specialized, heterogeneous subset of APCs that link innate sensing of pathogens with the activation of adaptive immunity [90].”
Background
Mass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies
Baharlou, H., Canete, N. P., Cunningham, A. L., Harman, A. N., & Patrick, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02657 · Cited by 176 · see citing works
“For example, cells that are ontogenically and therefore phenotypically closely related, can have distinct immunological functions and consequently play very different roles in disease pathogenesis (38, 84).”
Background
Exploring the Pivotal Immunomodulatory and Anti‐Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids
Richard, S. A. (2021) · Mediators of Inflammation · doi:10.1155/2021/6699560 · Cited by 177 · see citing works
“Their prime function is to bridge the innate as well as adaptive immune systems [48 – 50].”
scClassify: sample size estimation and multiscale classification of cells using single and multiple reference
Lin, Y., Cao, Y., Kim, H. J., Salim, A., Speed, T. P., Lin, D., Yang, P., & Yang, J. Y. H. (2020) · Molecular Systems Biology · doi:10.15252/msb.20199389 · Cited by 164 · see citing works
“In the first approach, marker genes were obtained from the published marker file from Garnett website and from published literature (Pang et al , 2005; Scarlett et al , 2011; Muraro et al , 2016; Lawlor et al , 2017; Collin & Bigley, 2018).”
Method
Polymeric nanoparticle vaccines to combat emerging and pandemic threats
Wibowo, D., Jorritsma, S. H. T., Gonzaga, Z. J., Evert, B. J., Chen, S., & Rehm, B. H. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120597 · Cited by 174 · see citing works
“DCs are often targeted by antigen-carrying nanoparticles, because DCs constitute a diverse subsets that plays major roles in initiating and regulating innate and adaptive immune responses [61].”
Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications
Fucikova, J. P., Palová-Jelínková, L., Bartůňková, J., & Špíšek, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02393 · Cited by 172 · see citing works
Dendritic cells in the tumor microenvironment: prognostic and theranostic impact
Verneau, J., Sautès‐Fridman, C., & Sun, C. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101410 · Cited by 168 · see citing works
Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy
Tian, H., Wang, G., Sang, W., Xie, L., Zhang, Z., Li, W., Yan, J., Tian, Y., Li, J., Li, B., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101405 · Cited by 165 · see citing works
Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development
Tout, I., Loureiro, D., Mansouri, A., Soumelis, V., Boyer, N., & Asselah, T. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.013 · Cited by 166 · see citing works
Review of Dendritic Cells, Their Role in Clinical Immunology, and Distribution in Various Animal Species
Zanna, M. Y., Yasmin, A. R., Omar, A. R., Arshad, S. S., Mariatulqabtiah, A. R., Nur-Fazila, S. H., & Isa, N. M. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158044 · Cited by 160 · see citing works
“The MP further differentiates into human monocytes, macrophages, and DC precursors (MDP), which will eventually give rise to monocytes and the common DC precursor [38], the term myeloid is commonly used to describe certain sets of antigen found on conventional DCs (cDCs) [39].”
Background
From periphery to center stage: 50 years of advancements in innate immunity
Carpenter, S. B., & O'Neill, L. A. J. (2024) · Cell · doi:10.1016/j.cell.2024.03.036 · Cited by 165 · see citing works
Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients
Toor, S. M., Murshed, K., Al‐Dhaheri, M., Khawar, M., Nada, M. A., & Elkord, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02936 · Cited by 160 · see citing works
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity
Saichi, M., Ladjemi, M. Z., Korniotis, S., Rousseau, C., Hamou, Z. A., Massenet-Regad, L., Amblard, E., Noël, F., Marie, Y., Bouteiller, D., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00681-2 · Cited by 151 · see citing works
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Dyring‐Andersen, B., Løvendorf, M. B., Coscia, F., Santos, A., Møller, L. B. P., Colaço, A. R., Niu, L., Bzorek, M., Doll, S., Andersen, J. L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19383-8 · Cited by 158 · see citing works
Immune Responses in Leishmaniasis: An Overview
Costa-da-Silva, A. C., Nascimento, D. D. O., Ferreira, J. R. M., Pinto, K. G., Freire‐de‐Lima, L., Morrot, A., Decotè-Ricardo, D., Filardy, A. A., & Freire-de-Lima, C. G. (2022) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed7040054 · Cited by 156 · see citing works
SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8
Salvi, V., Nguyen, H. O., Sozio, F., Schioppa, T., Gaudenzi, C., Laffranchi, M., Scapini, P., Passari, M., Barbazza, I., Tiberio, L., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150542 · Cited by 148 · see citing works
“These functions are largely shared among 241 different phenotypical and functional DC subsets (39).”
Influential
The role of innate immune cells in the tumor microenvironment and research progress in anti-tumor therapy
Lu, C., Liu, Y., Ali, N. M., Zhang, B., & Cui, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1039260 · Cited by 148 · see citing works
“In addition, cDCs can be further divided into two subsets termed type I (cDC1) and type II (cDC2) conventional DCs (64).”
Background
The pathogenesis of systemic lupus erythematosus: Harnessing big data to understand the molecular basis of lupus
Catalina, M. D., Owen, K. A., Labonte, A. C., Grammer, A. C., & Lipsky, P. E. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102359 · Cited by 145 · see citing works
Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy
Peng, X., He, Y., Huang, J. X., Tao, Y., & Liu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613492 · Cited by 146 · see citing works
Tissue‐resident innate immunity in the lung
Ardain, A., Marakalala, M. J., & Leslie, A. J. (2019) · Immunology · doi:10.1111/imm.13143 · Cited by 142 · see citing works
Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer
Brandum, E. P., Jørgensen, A. S., ROSENKILDE, M. M., & Hjortø, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158340 · Cited by 144 · see citing works
“However, whether this is truly a cDC population or instead moDCs might be the question since CD141, and CD1c, previously used to describe cDCs are also expressed by moDC [75].”
BackgroundInfluential
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast
Geldhof, V., de Rooij, L. P. M. H., Sokol, L., Amersfoort, J., Schepper, M. D., Rohlenová, K., Hoste, G., Vanderstichele, A., Delsupehe, A.-M., Isnaldi, E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33052-y · Cited by 141 · see citing works
Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
Wculek, S. K., Amores, J., Conde‐Garrosa, R., Khouili, S. C., Melero, I., & Sancho, D. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0565-5 · Cited by 143 · see citing works
Dexosomes as a cell-free vaccine for cancer immunotherapy
Nikfarjam, S., Rezaie, J., Kashanchi, F., & Jafari, R. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01781-x · Cited by 141 · see citing works
“Conventional DCs (cDCs), plasmacytoid DCs (pDCs) and monocyte-derived DCs (moDCs) comprise the three classic subsets of DCs in human [8, 9].”
Background
Regulatory Dendritic Cells, T Cell Tolerance, and Dendritic Cell Therapy for Immunologic Disease
Ness, S., Lin, S., & Gordon, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.633436 · Cited by 138 · see citing works
Histiocytosis
Emile, J., Aubart, F. C., Collin, M. P., Fraitag, S., Idbaïh, A., Abdel-Wahab, O. I., Rollins, B. J., Donadieu, J., & Haroche, J. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00311-1 · Cited by 138 · see citing works
CD4+ T cells in antitumor immunity
Montauti, E. I., Oh, D. Y., & Fong, L. H. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.07.009 · Cited by 140 · see citing works
Osteoinduction and osteoimmunology: Emerging concepts
Miron, R. J., Bohner, M., Zhang, Y., & Bosshardt, D. D. (2023) · Periodontology 2000 · doi:10.1111/prd.12519 · Cited by 135 · see citing works
Immune System Evasion as Hallmark of Melanoma Progression: The Role of Dendritic Cells
Tucci, M., Passarelli, A. M., Mannavola, F., Felici, C., Stucci, L. S., Cives, M., & Silvestris, F. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01148 · Cited by 132 · see citing works
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
Laureano, R. S., Sprooten, J., Vanmeerbeerk, I., Borràs, D., Govaerts, J., Naulaerts, S., Berneman, Z. N., Beuselinck, B., Bol, K. F., Borst, J. G., et al. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2096363 · Cited by 133 · see citing works
mRNA as novel technology for passive immunotherapy
Schlake, T., Theß, A., Thran, M., & Jordan, I. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2935-4 · Cited by 132 · see citing works
“Dendritic cells (DCs) process and present antigen for the transition from innate to adaptive immunity [7].”
Background
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite, E., Hertwig, L., Sinha, I., Ponzetta, A., Myrberg, I. H., Lourda, M., Dzidic, M., Akber, M., Klingström, J., Folkesson, E., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018587118 · Cited by 129 · see citing works
“Among cDCs, cDC1s are specialized in cross-presenting antigens to CD8 T cells while cDC2s initiate T-helper cell responses, both of which are essential for successful viral clearance (12).”
Background
Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity
Noubade, R., Majri-Morrison, S. S., & Tarbell, K. V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01014 · Cited by 130 · see citing works
Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?
Huber, A., Dammeijer, F. F., Aerts, J. G. J. V., & Vroman, H. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02804 · Cited by 124 · see citing works
The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy
Mpakali, A., & Stratikos, E. (2021) · Cancers · doi:10.3390/cancers13010134 · Cited by 126 · see citing works
Specialized immune responses in the peritoneal cavity and omentum
Liu, M., Silva-Sánchez, A., Randall, T. D., & Meza‐Perez, S. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mir0720-271rr · Cited by 128 · see citing works
Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy
Pérez‐Guijarro, E., Yang, H. H., Araya, R. E., Meskini, R. E., Michael, H. T., Vodnala, S. K., Marie, K. L., Smith, C., Chin, S., Lam, K. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0818-3 · Cited by 115 · see citing works
Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment
Guo, R., Lü, M., Cao, F., Wu, G., Gao, F., Pang, H., Li, Y., Zhang, Y., Xing, H., Liang, C., et al. (2021) · Biomarker Research · doi:10.1186/s40364-021-00265-0 · Cited by 119 · see citing works
Single-Cell RNA Sequencing in Multiple Pathologic Types of Renal Cell Carcinoma Revealed Novel Potential Tumor-Specific Markers
Su, C., Lv, Y., Lu, W., Yu, Z., Ye, Y., Guo, B., Liu, D., Yan, H., Li, T., Zhang, Q., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.719564 · Cited by 116 · see citing works
Ex vivo pulsed dendritic cell vaccination against cancer
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The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it
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Authors: Collin, M., & Bigley, V.
Affiliations: Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
Corresponding author: Collin, Matthew
ORCID: Collin, Matthew
Bigley, Venetia
Venue: Immunology
Publisher: Wiley
Published: 2018-02-27
Volume: 154
Issue: 1
Pages: 3-20
ISSN: 0019-2805 (ISSN-L)
1365-2567
DOI: 10.1111/imm.12888
PMC: PMC5904714
OpenAlex: W2781617771
Cited by: 1,301
References: 203
Citations by year: 2026: 69 · 2025: 169 · 2024: 167 · 2023: 191 · 2022: 237 · 2021: 198 · 2020: 155 · 2019: 87 · 2018: 27
FWCI: 11.83
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders: Cancer Research UK (C30484/A21025)
Wellcome Trust (101155/Z/13/Z)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cells, dendritic cell subsets, plasmacytoid dendritic cells, myeloid dendritic cells, DC1, DC2, transcription factors, IRF8, IRF4, PU.1, monocyte-derived dendritic cells, cell surface markers, innate immunity, adaptive immunity
MeSH terms: Kruppel-Like Factor 4, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunity, Phenotype, Signal Transduction, Biomarkers, Immunophenotyping

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