The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Insights into the initiation of TCR signaling
Open accessAbstract
The initiation of T cell antigen receptor signaling is a key step that can result in T cell activation and the orchestration of an adaptive immune response. Early events in T cell receptor signaling can distinguish between agonist and endogenous ligands with exquisite selectivity, and show extraordinary sensitivity to minute numbers of agonists in a sea of endogenous ligands. We review our current knowledge of models and crucial molecules that aim to provide a mechanistic explanation for these observations. Building on current understanding and a discussion of unresolved issues, we propose a molecular model for initiation of T cell receptor signaling that may serve as a useful guide for future studies.
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Cites
Digital signaling and hysteresis characterize Ras activation in lymphoid cells.
Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A. K., & Roose, J. P. (2009) · Cell · doi:10.1016/j.cell.2008.11.051 · Cited by 398
Self-citationLo, W.-L., Felix, N. J., Walters, J. J., Rohrs, H., Gross, M. L., & Allen, P. M. (2009) · Nature Immunology · doi:10.1038/ni.1796 · Cited by 105
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A framework for understanding the functions of biomolecular condensates across scales
Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells
Tanaka, A., Nishikawa, H., Noguchi, S., Sugiyama, D., Morikawa, H., Takeuchi, Y., Ha, D., Shigeta, N., Kitawaki, T., Maeda, Y., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191009 · Cited by 96
Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination
Brazin, K. N., Mallis, R. J., Das, D. K., Feng, Y., Hwang, W., Wang, J.-H., Wagner, G., Lang, M. J., & Reinherz, E. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00441 · Cited by 70
Yablonski, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01704 · Cited by 53
Metadata
- Authors
- Chakraborty, A. K., & Weiss, A.
- Venue
- Nature Immunology
- Published
- 2014-08-19
- Volume
- 15
- Issue
- 9
- Pages
- 798-807
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2065681262
- Cited by
- 353
- References
- 2
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
