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A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
Open accessAbstract
Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex and fully neutralized virus produced in either insect cells or primary human cells, with 50% neutralization in the low picomolar range. Our results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized.
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Cites
The global distribution and burden of dengue
Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., et al. (2013) · Nature · doi:10.1038/nature12060 · Cited by 10,037
Self-citationRELION: Implementation of a Bayesian approach to cryo-EM structure determination
Scheres, S. H. W. (2012) · Journal of Structural Biology · doi:10.1016/j.jsb.2012.09.006 · Cited by 5,446
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Katzelnick, L. C., Gresh, L., Halloran, M. E., Mercado, J. C., Kuan, G., Gordon, A., Balmaseda, A., & Harris, E. (2017) · Science · doi:10.1126/science.aan6836 · Cited by 1,205
Dejnirattisai, W., Supasa, P., Wongwiwat, W., Rouvinski, A., Barba-Spaeth, G., Duangchinda, T., Sakuntabhai, A., Cao-Lormeau, V.-M., Malasit, P., Rey, F. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3515 · Cited by 914
Self-citationSpecificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Stettler, K., Beltramello, M., Espinosa, D. A., Graham, V., Cassotta, A., Bianchi, S., Vanzetta, F., Minola, A., Jaconi, S., Mele, F., et al. (2016) · Science · doi:10.1126/science.aaf8505 · Cited by 758
Self-citationUltrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
Tortorici, M. A., Beltramello, M., Lempp, F. A., Pinto, D., Dang, H. V., Rosen, L. E., McCallum, M., Bowen, J., Minola, A., Jaconi, S., et al. (2020) · Science · doi:10.1126/science.abe3354 · Cited by 510
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
Priyamvada, L., Quicke, K. M., Hudson, W. H., Onlamoon, N., Sewatanon, J., Edupuganti, S., Pattanapanyasat, K., Chokephaibulkit, K., Mulligan, M. J., Wilson, P. C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607931113 · Cited by 587
Metadata
- Authors
- Dejnirattisai, W., Wongwiwat, W., Supasa, S., Zhang, X., Dai, X., Rouvinski, A., Jumnainsong, A., Edwards, C., Quyen, N. T. H., Duangchinda, T., Grimes, J. M., Tsai, W.-Y., Lai, C.-Y., Wang, W.-K., Malasit, P., Farrar, J., Simmons, C. P., Zhou, Z. H., Rey, F. A., Mongkolsapaya, J., & Screaton, G. R.
- Venue
- Nature Immunology
- Published
- 2014-12-15
- Volume
- 16
- Issue
- 2
- Pages
- 170-177
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2001568055
- Cited by
- 500
- References
- 2
- FWCI
- 45.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Dejnirattisai, W., Wongwiwat, W., Supasa, S., Zhang, X., Dai, X., Rouvinski, A., Jumnainsong, A., Edwards, C., Quyen, N. T. H., Duangchinda, T., Grimes, J. M., Tsai, W.-Y., Lai, C.-Y., Wang, W.-K., Malasit, P., Farrar, J., Simmons, C. P., Zhou, Z. H., Rey, F. A., . . . Screaton, G. R. (2015). A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus. Nature Immunology. https://doi.org/10.1038/ni.3058
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
