The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs
Open accessAbstract
Innate lymphoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs (ILC1 cells) and group 3 ILCs (ILC3 cells) have been shown to be functionally plastic. Here we found that group 2 ILCs (ILC2 cells) also exhibited phenotypic plasticity in response to infectious or noxious agents, characterized by substantially lower expression of the transcription factor GATA-3 and a concomitant switch to being ILC1 cells that produced interferon-γ (IFN-γ). Interleukin 12 (IL-12) and IL-18 regulated this conversion, and during viral infection, ILC2 cells clustered within inflamed areas and acquired an ILC1-like phenotype. Mechanistically, these ILC1 cells augmented virus-induced inflammation in a manner dependent on the transcription factor T-bet. Notably, IL-12 converted human ILC2 cells into ILC1 cells, and the frequency of ILC1 cells in patients with chronic obstructive pulmonary disease (COPD) correlated with disease severity and susceptibility to exacerbations. Thus, functional plasticity of ILC2 cells exacerbates anti-viral immunity, which may have adverse consequences in respiratory diseases such as COPD.
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Citations
Cites
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
T-bet: a bridge between innate and adaptive immunity
Lazarevic, V., Glimcher, L. H., & Lord, G. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3536 · Cited by 486
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
Byers, D. E., Alexander-Brett, J., Patel, A. C., Agapov, E., Dang-Vu, G., Jin, X., Wu, K., You, Y., Alevy, Y., Girard, J.-P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65570 · Cited by 337
Cited by
Gury-BenAri, M., Thaiss, C. A., Serafini, N., Winter, D. R., Giladi, A., Lara-Astiaso, D., Levy, M., Salame, T. M., Weiner, A., David, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.043 · Cited by 587
Type 2 immunity in the skin and lungs
Akdis, C. A., Arkwright, P. D., Brüggen, M.-C., Busse, W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 560
Role of inflammatory cells in airway remodeling in COPD
Wang, Y., Xu, J., Meng, Y., Adcock, I. M., & Yao, X. (2018) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s176122 · Cited by 373
Innate lymphoid cells: major players in inflammatory diseases
Ebbo, M., Crinier, A., Vély, F., & Vivier, E. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.86 · Cited by 363
Plasticity of innate lymphoid cell subsets
Bal, S. M., Golebski, K., & Spits, H. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0282-9 · Cited by 304
Metadata
- Authors
- Silver, J. S., Kearley, J., Copenhaver, A. M., Sanden, C., Mori, M., Yu, L., Pritchard, G. H., Berlin, A. A., Hunter, C. A., Bowler, R., Erjefalt, J. S., Kolbeck, R., & Humbles, A. A.
- Venue
- Nature Immunology
- Published
- 2016-04-25
- Volume
- 17
- Issue
- 6
- Pages
- 626-635
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2344776862
- Cited by
- 446
- References
- 3
- FWCI
- 29.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Silver, J. S., Kearley, J., Copenhaver, A. M., Sanden, C., Mori, M., Yu, L., Pritchard, G. H., Berlin, A. A., Hunter, C. A., Bowler, R., Erjefalt, J. S., Kolbeck, R., & Humbles, A. A. (2016). Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Nature Immunology. https://doi.org/10.1038/ni.3443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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