The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
Open accessAbstract
The paracaspase MALT1 is pivotal in antigen receptor–mediated lymphocyte activation and lymphomagenesis. MALT1 contains a caspase-like domain, but it is unknown whether this domain is proteolytically active. Here we report that MALT1 had arginine-directed proteolytic activity that was activated after T cell stimulation, and we identify the signaling protein Bcl-10 as a MALT1 substrate. Processing of Bcl-10 after Arg228 was required for T cell receptor–induced cell adhesion to fibronectin. In contrast, MALT1 activity but not Bcl-10 cleavage was essential for optimal activation of transcription factor NF-κB and production of interleukin 2. Thus, the proteolytic activity of MALT1 is central to T cell activation, which suggests a possible target for the development of immunomodulatory or anticancer drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanisms of caspase activation
Boatright, K. M., & Salvesen, G. S. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.009 · Cited by 1,377
Uren (2000) · Molecular Cell · Cited by 965
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., & Ruland, J. (2006) · Nature · doi:10.1038/nature04926 · Cited by 853
Sun, L., Deng, L., Ea, C.-K., Xia, Z.-P., & Chen, Z. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00236-9 · Cited by 699
Analytical techniques for cell fractions
Pearson, T., & Anderson, L. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90203-1 · Cited by 622
Ruland, J., Duncan, G. S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A., Ohashi, P. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00189-1 · Cited by 553
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02273 · Cited by 527
Intracellular signalling controlling integrin activation in lymphocytes
Kinashi, T. (2005) · Nature Reviews Immunology · doi:10.1038/nri1646 · Cited by 477
Uren, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00094-0 · Cited by 459
Analytical techniques for cell fractions
Anderson, N. L., & Anderson, N. G. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90230-0 · Cited by 426
Cited by
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Correa Marrero, M., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 1,020
Programmed cell death in the plant immune system
Coll, N. S., Epple, P., & Dangl, J. L. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.37 · Cited by 915
Staudt, L. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000109 · Cited by 485
Targeting pathological B cell receptor signalling in lymphoid malignancies
Young, R. M., & Staudt, L. M. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3937 · Cited by 401
Metadata
- Authors
- Rebeaud, F., Hailfinger, S., Posevitz-Fejfar, A., Tapernoux, M., Moser, R., Rueda, D., Gaide, O., Guzzardi, M., Iancu, E. M., Rufer, N., Fasel, N., & Thome, M.
- Venue
- Nature Immunology
- Published
- 2008-02-10
- Volume
- 9
- Issue
- 3
- Pages
- 272-281
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1984358344
- Cited by
- 310
- References
- 47
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The proteolytic activity of the paracaspase MALT1 is key in T cell activation. https://app.cochat.ai/papers/10.1038/ni1568
- The paper
- Rebeaud, F., Hailfinger, S., Posevitz-Fejfar, A., Tapernoux, M., Moser, R., Rueda, D., Gaide, O., Guzzardi, M., Iancu, E. M., Rufer, N., Fasel, N., & Thome, M. (2008). The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nature Immunology. https://doi.org/10.1038/ni1568
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
