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Cited by 2,144T-cell and B-cell ImmunologyCell Adhesion Molecules ResearchImmune Response and Inflammation

T Cell Activation

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Smith-Garvin, Jennifer E., Koretzky, Gary A., Jordan, Martha S.·2009·Annual Review of Immunology
DOI 10.1146/annurev.immunol.021908.132706PMC PMC2740335
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Abstract

This year marks the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals. This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory molecules, and how signals may negatively regulate T cell function.Acronyms and DefinitionsAdapter protein: cellular protein that functions to bridge molecular interactions via characteristic domains able to mediate protein/protein or protein/lipid interactions Costimulation: signals delivered to T cells by cell surface receptors other than the TCR itself that potentiate T cell activation cSMAC: central supramolecular activation cluster Immunoreceptor tyrosine-based activation motif (ITAM): a short peptide sequence in the cytoplasmic tails of key surface receptors on hematopoietic cells that is characterized by tyrosine residues that are phosphorylated by Src family PTKs, enabling the ITAM to recruit activated Syk family kinases Inside-out signaling: signals initiated by engagement of immunoreceptors that lead to conformational changes and clustering of integrins, thereby increasing the affinity and avidity of the integrins for their ligands NFAT: nuclear factor of activated T cells PI3K: phosphoinositide 3-kinase PKC: protein kinase C PLC: phospholipase C pMHC: peptide major histocompatibility complex (MHC) complex pSMAC: peripheral supramolecular activation cluster PTK: protein tyrosine kinase Signal transduction: biochemical events linking surface receptor engagement to cellular responses TCR: T cell antigen receptor

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Crossref · 10.1146/annurev.immunol.021908.132706

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  • TCR+IL-2 treatment of resting and activated human CD4+ and CD8+ T cells activated a vast array of signaling intermediaries detected by the antibody array, serving as a positive control.

    “In both resting and activated human CD4+ and CD8+ T cells, TCR+IL-2 treatment led to the activation of a vast array of signaling intermediaries, including STAT1, STAT3, STAT4, STAT5, STAT6, ERK, AKT, S6R, CREB”

    From CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci (2020) · cites this paper as Smith-Garvin et al., 2009

    The DAG-Mediated Signaling Pathways section says TCR signaling activates ERK and STAT3, supporting part of the signaling claim. The review does not report TCR+IL-2 treatment of resting and activated human CD4+ and CD8+ cells, an antibody-array positive control, or activation of the full listed set of intermediaries. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S.
Affiliations
  • Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104;
  • University of Pennsylvania (US)
ORCID
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2009-04-01
Volume
27
Issue
1
Pages
591-619
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev.immunol.021908.132706
PMC
PMC2740335
OpenAlex
W2100412095
Cited by
2,144
References
3
Citations by year
2026: 102 · 2025: 123 · 2024: 127 · 2023: 112 · 2022: 114 · 2021: 170 · 2020: 144 · 2019: 130 · 2018: 101 · 2017: 108 · 2016: 145 · 2015: 121 · 2014: 128 · 2013: 136 · 2012: 143
FWCI
9.84
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (P01CA093615)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
T cell activation, T cell receptor signaling, costimulation, integrin signaling, costimulatory molecules, ITAM, adaptor proteins, signal transduction
MeSH terms
Actins, Animals, Cytoskeleton, Humans, Lymphocyte Activation, Receptors, Antigen, T-Cell, Signal Transduction, Integrins, T-Lymphocyte Subsets, Cytokines, CD3 Complex

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