TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,651

SH2 domains recognize specific phosphopeptide sequences

Songyang, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90404-e · Cited by 2,620

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

Ferrell, J. E., & Machleder, E. M. (1998) · Science · doi:10.1126/science.280.5365.895 · Cited by 1,052

The Biochemistry and Cell Biology of Antigen Processing and Presentation

Germain, R. N., & Margulies, D. H. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.002155 · Cited by 1,003

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

Seder, R. A., Paul, W. E., Davis, M. M., & Groth, B. F. D. S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1091 · Cited by 994

Kinetic proofreading in T-cell receptor signal transduction.

McKeithan, T. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5042 · Cited by 964

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., & Shevach, E. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1224 · Cited by 829

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., & Pouysségur, J. (1999) · Science · doi:10.1126/science.286.5443.1374 · Cited by 654

Receptor clustering as a cellular mechanism to control sensitivity

Bray, D., Levin, M. D., & Morton-Firth, C. J. (1998) · Nature · doi:10.1038/30018 · Cited by 613

KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs

Lin, J., Harding, A. S., Giurisato, E., & Shaw, A. S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01634-08 · Cited by 42

Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease

Pike, K. A., & Tremblay, M. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02504 · Cited by 43

K-RAS GTPase- and B-RAF kinase–mediated T-cell tolerance defects in rheumatoid arthritis

Singh, K., Deshpande, P., Li, G., Yu, M., Pryshchep, S., Cavanagh, M., Weyand, C. M., & Goronzy, J. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117640109 · Cited by 41

Feedback control of T–cell receptor activation

Chan, C. C. W., Stark, J., & George, A. J. T. (2004) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2003.2587 · Cited by 40

Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Kondo, T., Bourassa, F. X. P., Achar, S. R., DuSold, J., Céspedes, P. F., Ando, M., Dwivedi, A., Moraly, J., Chien, C. D., Majdoul, S., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.017 · Cited by 40

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

Zhu, Z., Li, R., Li, H., Zhou, T., & Davis, R. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215156110 · Cited by 41

Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential

Rogers, D., Sood, A., Wang, H., van Beek, J. J. P., Rademaker, T. J., Artusa, P., Schneider, C., Shen, C., Wong, D. C., Bhagrath, A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110064 · Cited by 39

Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer

Hebeisen, M., Oberle, S. G., Presotto, D., Speiser, D. E., Zehn, D., & Rufer, N. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00154 · Cited by 39

Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity

Sitaram, P., Uyemura, B. S., Malarkannan, S., & Riese, M. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235821 · Cited by 39

Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics

Rosenthal, K. M., Edwards, L. J., Sabatino, J. J., Hood, J. D., Wasserman, H. A., Zhu, C., & Evavold, B. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032562 · Cited by 38

Positive and negative regulation of antigen receptor signaling by the Shc family of protein adapters

Finetti, F., Savino, M. T., & Baldari, C. T. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00826.x · Cited by 39

Initiation of TCR signalling revisited

Trautmann, A., & Randriamampita, C. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00182-0 · Cited by 38

THEMIS: a critical TCR signal regulator for ligand discrimination

Gascoigne, N. R. J., & Acuto, O. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.01.020 · Cited by 37

Immunological synapse: a multi‐protein signalling cellular apparatus for controlling gene expression

Padhan, K., & Varma, R. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03241.x · Cited by 38

Urolithin A Hijacks ERK1/2‐ULK1 Cascade to Improve CD8+ T Cell Fitness for Antitumor Immunity

Ma, S., Wu, Q., Wu, W., Tian, Y., Zhang, J., Chen, C., Sheng, X., Zhao, F., Ding, L., Wang, T., et al. (2024) · Advanced Science · doi:10.1002/advs.202310065 · Cited by 40

SAP Facilitates Recruitment and Activation of LCK at NTB-A Receptors during Restimulation-Induced Cell Death

Katz, G., Krummey, S. M., Larsen, S. E., Stinson, J. R., & Snow, A. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303070 · Cited by 36

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

Ishikawa, E., Kosako, H., Yasuda, T., Ohmuraya, M., Araki, K., Kurosaki, T., Saito, T., & Yamasaki, S. (2016) · Nature Communications · doi:10.1038/ncomms12756 · Cited by 36

Lck-Dependent Tyrosine Phosphorylation of Diacylglycerol Kinase α Regulates Its Membrane Association in T Cells

Merino, E., Ávila‐Flores, A., Shirai, Y., Moraga, I., Saito, N., & Mérida, I. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5805 · Cited by 36

CAML Is a p56Lck-Interacting Protein that Is Required for Thymocyte Development

Tran, D. D., Edgar, C. E., Heckman, K. L., Sutor, S. L., Huntoon, C. J., van Deursen, J., McKean, D. L., & Bram, R. J. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.006 · Cited by 36

Immunoglobulin A Antibodies: From Protection to Harmful Roles

Gleeson, P. J., Câmara, N. O. S., Launay, P., Lehuen, A., & Monteiro, R. C. (2024) · Immunological Reviews · doi:10.1111/imr.13424 · Cited by 34

T cell recognition of weak ligands: roles of signaling, receptor number, and affinity

Edwards, L. J., & Evavold, B. D. (2011) · Immunologic Research · doi:10.1007/s12026-011-8204-3 · Cited by 34

Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28

Helou, Y. A., Petrashen, A. P., & Salomon, A. R. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00340 · Cited by 36

SH2 Domain-Containing Protein-Tyrosine Phosphatases

Neel, B. G., Chan, G., & Dhanji, S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00098-x · Cited by 34

TCR activation kinetics and feedback regulation in primary human T cells

Poltorak, M. P., Arndt, B., Kowtharapu, B. S., Reddycherla, A. V., Witte, A. V., Lindquist, J. A., Schraven, B. L., & Simeoni, L. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-4 · Cited by 34

Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP‐1‐deficient mice

Massa, P. T., Wu, C. W., & Fecenko-Tacka, K. L. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20155 · Cited by 34

ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells

Helou, Y. A., Nguyen, V. T., Beik, S. P., & Salomon, A. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069641 · Cited by 33

Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals

Arranz‐Nicolás, J., Ogando, J., Soutar, D., Arcos, R., Meraviglia-Crivelli, D., Mañes, S., Mérida, I., & Ávila‐Flores, A. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2154-8 · Cited by 33

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects

Yi, T., Elson, P. J., Mitsuhashi, M., Jacobs, B., Hollovary, E., Budd, G. T., Spiro, T. P., Triozzi, P. L., & Borden, E. C. (2011) · Oncotarget · doi:10.18632/oncotarget.563 · Cited by 33

Modulation of CD1d-restricted NKT cell responses by CD4

Chen, X., Wang, X., Besra, G. S., & Gumperz, J. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307163 · Cited by 33

Mathematical Models and Immune Cell Biology

Molina-Parı́s, C., & Lythe, G. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7725-0 · Cited by 34

Fine-tuning lymphocyte regulation: what’s new with tyrosine kinases and phosphatases?

Cannons, J. L., & Schwartzberg, P. L. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.03.011 · Cited by 33

Enhancement of T Cell Responses as a Result of Synergy between Lower Doses of Radiation and T Cell Stimulation

Spary, L. K., Al‐Taei, S., Salimu, J., Cook, A. D., Ager, A., Watson, H. A., Clayton, A., Staffurth, J. N., Mason, M. D., & Tabi, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302736 · Cited by 32

Superantigen Stimulation Reveals the Contribution of Lck to Negative Regulation of T Cell Activation

Criado, G., & Madrenas, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.222 · Cited by 32

Simple biochemical networks allow accurate sensing of multiple ligands with a single receptor

Singh, V., & Nemenman, I. M. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005490 · Cited by 34

Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints

Kreileder, M., Barrett, I. P., Bendtsen, C., Brennan, D. J., & Kölch, W. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.001 · Cited by 31

Robust control of the adaptive immune system

Wong, H. S., & Germain, R. N. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.009 · Cited by 32

Short-Interfering RNA-Mediated Lck Knockdown Results in Augmented Downstream T Cell Responses

Méthi, T., Ngai, J., Mahic, M., Amarzguioui, M., Vang, T., & Taskén, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7398 · Cited by 31

The conundrum of inhibitory signaling by ITAM‐containing immunoreceptors: Potential molecular mechanisms

Waterman, P. M., & Cambier, J. C. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.029 · Cited by 30

MicroRNA miR-181—A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function

Grewers, Z., & Krueger, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176200 · Cited by 30

Mathematical Modeling of Chimeric TCR Triggering Predicts the Magnitude of Target Lysis and Its Impairment by TCR Downmodulation

James, S. E., Greenberg, P. D., Jensen, M. C., Lin, Y., Wang, J., Budde, L. E., Till, B. G., Raubitschek, A. A., Forman, S. J., & Press, O. W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903701 · Cited by 30

CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides

Gaud, G., Achar, S. R., Bourassa, F. X. P., Davies, J., Hatzihristidis, T., Choi, S., Kondo, T., Gossa, S., Lee, J., Juneau, P. L., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01663-2 · Cited by 32

The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr 192

Granum, S., Sundvold‐Gjerstad, V., Gopalakrishnan, R. P., Berge, T., Koll, L., Abrahamsen, G., Sørlie, M., & Spurkland, A. (2014) · Science Signaling · doi:10.1126/scisignal.2005384 · Cited by 29

Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury

Sánchez‐Quiles, V., Segura, V., Bigaud, E., He, B., O’Malley, B. W., Santamaría, E., Prìeto, J., & Corrales, F. J. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.08.009 · Cited by 30

Activation or Tolerance of Natural Killer Cells Is Modulated by Ligand Quality in a Nonmonotonic Manner

Das, J. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.07.061 · Cited by 29

Understanding the Dynamics of T-Cell Activation in Health and Disease Through the Lens of Computational Modeling

Rohrs, J. A., Wang, P., & Finley, S. D. (2019) · JCO Clinical Cancer Informatics · doi:10.1200/cci.18.00057 · Cited by 28

T cells use distinct topographical and membrane receptor scanning strategies that individually coalesce during receptor recognition

Cai, E., Beppler, C., Eichorst, J. P., Marchuk, K., Eastman, S. W., & Krummel, M. F. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203247119 · Cited by 27

The Late Endosomal Transporter CD222 Directs the Spatial Distribution and Activity of Lck

Pfisterer, K., Forster, F., Paster, W., Supper, V., Ohradanova‐Repic, A., Eckerstorfer, P., Zwirzitz, A., Donner, C., Boulègue, C., Schiller, H. B., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303349 · Cited by 27

Antigen-Dependent Integration of Opposing Proximal TCR-Signaling Cascades Determines the Functional Fate of T Lymphocytes

Wolchinsky, R., Hod-Marco, M., Oved, K., Shen-Orr, S. S., Bendall, S. C., Nolan, G. P., & Reiter, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301142 · Cited by 28

T Cell Activation

Mak, T. W., & Saunders, M. E. (2006) · Elsevier eBooks · doi:10.1016/b978-012088451-3.50016-8 · Cited by 28

TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1–Mediated Inactivation of LCK

Ormonde, J. V. S., Li, Z., Stegen, C., & Madrenas, J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800284 · Cited by 27

TCR-Dependent Cell Response Is Modulated by the Timing of CD43 Engagement

Fierro, N. A., Pedraza‐Alva, G., & Rosenstein, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7346 · Cited by 28

Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling

Itoh, Y., Wang, Z., Ishida, H., Eichelberg, K., Fujimoto, N., Makino, J., Ogasawara, K., & Germain, R. N. (2005) · European Journal of Immunology · doi:10.1002/eji.200526064 · Cited by 27

Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection

Vanguri, V. K., Govern, C. C., Smith, R. L., & Huseby, E. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208328110 · Cited by 26

Immunological Paradigms, Mechanisms, and Models: Conceptual Understanding Is a Prerequisite to Effective Modeling

Grossman, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02522 · Cited by 27

Modification of peptide interaction with MHC creates TCR partial agonists

Ryan, K. R., McNeil, L. K., Dao, C. T., Jensen, P. E., & Evavold, B. D. (2004) · Cellular Immunology · doi:10.1016/j.cellimm.2004.01.003 · Cited by 26

Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy

Lopresti, L., Tatangelo, V., Baldari, C. T., & Patrussi, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1418527 · Cited by 27

T Cell Receptor Signaling Kinetics Takes the Stage

Sykulev, Y. K. (2010) · Science Signaling · doi:10.1126/scisignal.3153pe50 · Cited by 25

Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse

Kim, B., Kim, H. Y., & Lee, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.687367 · Cited by 25

Themis is indispensable for IL-2 and IL-15 signaling in T cells

Liu, Y., Yu, C., Niu, Y., Yin, Y., Tan, F., Lai, Q., Hu, Y., Hou, B., Li, J., Lin, C., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abi9983 · Cited by 26

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions

Kästle, M., Merten, C., Hartig, R., Kaehne, T., Liaunardy-Jopeace, A., Woessner, N. M., Schamel, W. W. A., James, J. R., Minguet, S., Simeoni, L., et al. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00673-z · Cited by 25

Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a

DeBell, K. E., Simhadri, V. R., Mariano, J. L., & Borrego, F. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-23 · Cited by 26

Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells

Cao, L., Ding, Y., Hung, N., Yu, K., Ritz, A., Raphael, B. J., & Salomon, A. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046725 · Cited by 24

Interferon-β treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1

Christophi, G. P., Panos, M., Hudson, C. A., Tsikkou, C., Mihai, C., Mejico, L. J., Jubelt, B., & Massa, P. T. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.05.019 · Cited by 24

Tuning the immune system: competing positive and negative feedback loops

Mueller, D. L. (2003) · Nature Immunology · doi:10.1038/ni0303-210 · Cited by 24

Regulation of the Tyrosine Kinase Pyk2 by Calcium Is through Production of Reactive Oxygen Species in Cytotoxic T Lymphocytes

Lysechko, T. L., Cheung, S., & Ostergaard, H. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118265 · Cited by 24

The role of competing mechanisms on Lck regulation

Bozso, S. J., Kang, J. J. H., & Nagendran, J. (2020) · Immunologic Research · doi:10.1007/s12026-020-09148-2 · Cited by 23

Degenerate recognition of T cell epitopes: impact of T cell receptor reserve and stability of peptide:MHC complexes

FORD, M. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.11.004 · Cited by 23

Receptor Sensitivity: When T cells Lose Their Sense of Self

Hogquist, K. A., Starr, T. K., & Jameson, S. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00161-1 · Cited by 23

The Activation Threshold of CD4+ T Cells Is Defined by TCR/Peptide-MHC Class II Interactions in the Thymic Medulla

Stephen, T. L., Tikhonova, A. N., Riberdy, J. M., & Laufer, T. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901104 · Cited by 22

RasGRP1 Transmits Prodifferentiation TCR Signaling That Is Crucial for CD4 T Cell Development

Priatel, J. J., Chen, X., Dhanji, S., Abraham, N., & Teh, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1470 · Cited by 22

Multiple Microclusters: Diverse Compartments Within the Immune Synapse

Bunnell, S. C. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-03858-7_7 · Cited by 22

T cell responses to antigen: hasty proposals resolved through long engagements

Tkach, K. E., & Altan-Bonnet, G. Y. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.12.001 · Cited by 22

The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity

Sun, Y., Zhu, X., Chen, X., Liu, H., Xu, Y., Chu, Y., Wang, G., & Liu, X. (2014) · Nature Communications · doi:10.1038/ncomms6225 · Cited by 23

The Mitogen-Activated Protein Kinase Scaffold KSR1 Is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological Synapse

Giurisato, E., Lin, J., Harding, A. S., Cerutti, E., Cella, M., Lewis, R. E., Colonna, M., & Shaw, A. S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01421-08 · Cited by 22

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells

Priatel, J. J., Chen, X., Huang, Y., Chow, M., Zenewicz, L. A., Coughlin, J. J., Shen, H., Stone, J. C., Tan, R., & Teh, H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803521 · Cited by 22

The death effector domain protein PEA‐15 negatively regulates T‐cell receptor signaling

Pastorino, S., Renganathan, H., Caliva, M. J., Filbert, E. L., Opoku‐Ansah, J., Sulzmaier, F. J., Gawecka, J. E., Werlen, G., Shaw, A. S., & Ramos, J. W. (2010) · The FASEB Journal · doi:10.1096/fj.09-144295 · Cited by 22

Bioorthogonal Engineering of Bacterial Effectors for Spatial–Temporal Modulation of Cell Signaling

Zhao, J., Liu, Y., Lin, F., Wang, W., Yang, S., Ge, Y., & Chen, P. R. (2018) · ACS Central Science · doi:10.1021/acscentsci.8b00751 · Cited by 21

Activation of Cdk2 Stimulates Proteasome-dependent Truncation of Tyrosine Phosphatase SHP-1 in Human Proliferating Intestinal Epithelial Cells

Simoneau, M., Boulanger, J., Coulombe, G., Renaud, M., Duchesne, C., & Rivard, N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804177200 · Cited by 21

Dynamic Regulation of Tec Kinase Localization in Membrane-proximal Vesicles of a T Cell Clone Revealed by Total Internal Reflection Fluorescence and Confocal Microscopy

Kane, L., & Watkins, S. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412913200 · Cited by 20

Extrathymic Generation of Regulatory T Cells—Chances and Challenges for Prevention of Autoimmune Disease

Daniel, C., & von Boehmer, H. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387827-4.00005-x · Cited by 21

CD43 – One molecule, many tales to recount

Pedraza‐Alva, G., & Rosenstein, Y. (2007) · Signal Transduction · doi:10.1002/sita.200700140 · Cited by 20

Towards multiscale modeling of the CD8+T cell response to viral infections

Baral, S., Raja, R., Sen, P., & Dixit, N. M. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1446 · Cited by 20

MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1

Wasserman, H. A., Beal, C. D., Zhang, Y., Jiang, N. J., Zhu, C., & Evavold, B. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6843 · Cited by 20

Lck SH3 Domain Function Is Required for T-Cell Receptor Signals Regulating Thymocyte Development

Rudd, M. L., Tua-Smith, A., & Straus, D. B. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00968-06 · Cited by 20

HIV‐1 Replication Is Stimulated by Sodium Stibogluconate, the Therapeutic Mainstay in the Treatment of Leishmaniasis

Barat, C., Zhao, C., Ouellette, M., & Tremblay, M. J. (2006) · The Journal of Infectious Diseases · doi:10.1086/510398 · Cited by 20

New Approaches to Investigate Drug-Induced Hypersensitivity

Ogese, M. O., Ahmed, S. S., Alferivic, A., Betts, C. J., Dickinson, A. M., Faulkner, L., French, N. S., Gibson, A., Hirschfield, G. M., Kammuller, M. E., et al. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00333 · Cited by 19

Antiviral activity of zinc against hepatitis viruses: current status and future prospects

Kumar, S., Ansari, S., Narayanan, S., Ranjith-Kumar, C. T., & Surjit, M. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1218654 · Cited by 20

Unexpected role for MHC II–peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo

Do, J., Valujskikh, A., Vignali, D. A. A., Fairchild, R. L., & Min, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207219109 · Cited by 19

Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection

Garreau, A., Blaize, G., Argenty, J., Rouquié, N., Tourdès, A., Wood, S. A., Saoudi, A., & Lesourne, R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700566 · Cited by 19

A Phospholipase C-γ1–Independent, RasGRP1-ERK–Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells–Y136F Mutant Mice

Kortum, R. L., Rouquette‐Jazdanian, A. K., Miyaji, M., Merrill, R. K., Markegard, E., Pinski, J. M., Wesselink, A. K., Nath, N. N., Alexander, C. P., Li, W., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201458 · Cited by 20

An alternative mode of CD 43 signal transduction activates pro‐survival pathways of T lymphocytes

Bravo‐Adame, M. E., Vera‐Estrella, R., Barkla, B. J., Campos, C. M., Flores‐Alcantar, A., Ocelotl-Oviedo, J. P., Pedraza‐Alva, G., & Rosenstein, Y. (2016) · Immunology · doi:10.1111/imm.12670 · Cited by 19

Proofreading does not result in more reliable ligand discrimination in receptor signaling due to its inherent stochasticity

Kirby, D., & Zilman, A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212795120 · Cited by 18

TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model

Eiro, M. D. C., Hioki, K., Li, L. V., Wilmsen, M. E. P., Kiernan, C. H., Brouwers-Haspels, I., van Meurs, M., Zhao, M., de Wit, H., Grashof, D. G. B., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300038 · Cited by 18

Consideration of SHP-1 as a Molecular Target for Tumor Therapy

Lim, S., Lee, K. W., Kim, J. Y., & Kim, K. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010331 · Cited by 18

Modelling the Tunability of Early T Cell Signalling Events

Owens, N. D. L., Timmis, J., Greensted, A. J., & Tyrrell, A. M. (2008) · Lecture notes in computer science · doi:10.1007/978-3-540-85072-4_2 · Cited by 18

Regulating naïve and memory CD8 T cell homeostasis – a role for protein tyrosine phosphatases

Pike, K. A., & Tremblay, M. L. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08587.x · Cited by 19

Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation

Rohrs, J. A., Wang, P., & Finley, S. D. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0438-7 · Cited by 18

Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function

Basu, J. M., Reis, B. S., Peri, S., Zha, J., Hua, X., Ge, L., Ferchen, K., Nicolas, É., Czyzewicz, P., Cai, K. Q., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00980-8 · Cited by 19

T-Cell Activation: A Queuing Theory Analysis at Low Agonist Density

Wedagedera, J. R., & Burroughs, N. J. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.066001 · Cited by 18

Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future

Germain, R. N. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.027 · Cited by 17

Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 2005; 3:e356. [PubMed: 16231973

Germain, R. N. (2016)

Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

Altan-Bonnet, G. Y., & Germain, R. N. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030356 · Cited by 463

Tailoring T-cell receptor signals by proximal negative feedback mechanisms

Acuto, O., Bartolo, V. D., & Michel, F. (2008) · Nature reviews. Immunology · doi:10.1038/nri2397 · Cited by 245

Elucidation of T cell signalling models

Owens, N. D. L., Timmis, J., Greensted, A. J., & Tyrrell, A. M. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.10.017 · Cited by 11

Adapting T Cell Receptor Ligand Discrimination Capability via LAT

Lo, W., & Weiss, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673196 · Cited by 31