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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Abstract
Functional discrimination between structurally similar self and foreign antigens is a main attribute of adaptive immunity. Here we describe two feedback mechanisms in T lymphocytes that together sharpen and amplify initial signaling differences related to the quality of T cell receptor (TCR) engagement. Weakly binding ligands predominantly trigger a negative feedback loop leading to rapid recruitment of the tyrosine phosphatase SHP-1, followed by receptor desensitization through inactivation of Lck kinase. In contrast, strongly binding ligands efficiently activate a positive feedback circuit involving Lck modification by ERK, preventing SHP-1 recruitment and allowing the long-lasting signaling necessary for gene activation. The characteristics of these pathways suggest that they constitute an important part of the mechanism allowing T cells to discriminate between self and foreign ligands.
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“DUSP6 dephosphorylates ERK, not only attenuating ERK signaling after TCR activation but also interfering with a forward feedback loop in TCR signaling”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Stefanová et al., 2003
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1 retracted
Parijs, L. V., Refaeli, Y., Lord, J. D., Nelson, B. H., Abbas, A. K., & Baltimore, D. (1999) · Immunity · doi:10.1016/s1074-7613(00)80103-x · Cited by 420
RetractedRAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,651
SH2 domains recognize specific phosphopeptide sequences
Songyang, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90404-e · Cited by 2,620
The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes
Ferrell, J. E., & Machleder, E. M. (1998) · Science · doi:10.1126/science.280.5365.895 · Cited by 1,052
The Biochemistry and Cell Biology of Antigen Processing and Presentation
Germain, R. N., & Margulies, D. H. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.002155 · Cited by 1,003
Self-citationSeder, R. A., Paul, W. E., Davis, M. M., & Groth, B. F. D. S. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1091 · Cited by 994
Kinetic proofreading in T-cell receptor signal transduction.
McKeithan, T. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5042 · Cited by 964
Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., & Shevach, E. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1224 · Cited by 829
Self-citationDefective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice
Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., & Pouysségur, J. (1999) · Science · doi:10.1126/science.286.5443.1374 · Cited by 654
Receptor clustering as a cellular mechanism to control sensitivity
Bray, D., Levin, M. D., & Morton-Firth, C. J. (1998) · Nature · doi:10.1038/30018 · Cited by 613
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Mbiribindi, B., Mukherjee, S., Wellington, D., Das, J., & Khakoo, S. I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00605 · Cited by 17
Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation
Houde, N., Beuret, L., Bonaud, A., Fortier-Beaulieu, S.-P., Truchon-Landry, K., Aoidi, R., Pic, É., Alouche, N., Rondeau, V., Schlecht‐Louf, G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110223 · Cited by 16
Ji, Q., Ding, Y., & Salomon, A. R. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.037861 · Cited by 16
Lyn Kinase Structure, Regulation, and Involvement in Neurodegenerative Diseases: A Mini Review
Weerawarna, P. M., & Richardson, T. I. (2023) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases1010004 · Cited by 16
Dong, S., Corre, B., Nika, K., Pellegrini, S., & Michel, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015114 · Cited by 19
The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection
Huang, F., Huang, W., Briggs, J., Chew, T. W., Bai, Y., Deol, S., & August, A. (2015) · Scientific Reports · doi:10.1038/srep07688 · Cited by 16
Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse
González, P. A., Carreño, L. J., Céspedes, P. F., Bueno, S. M., Riedel, C. A., & Kalergis, A. M. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/450291 · Cited by 16
Klauschen, F., Angermann, B. R., & Meier‐Schellersheim, M. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03472.x · Cited by 16
Castro-Sánchez, P., Aguilar-Sopeña, Ó., Alegre-Gómez, S., Ramirez-Munoz, R., & Roda‐Navarro, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01447 · Cited by 15
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Wertek, F., & Xu, C. (2014) · Cell Research · doi:10.1038/cr.2014.5 · Cited by 15
Yu, Z., Maoui, M., Zhao, Z. J., Li, Y., & Shen, S. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05233.x · Cited by 15
Boldizsár, F., Kis‐Tóth, K., Tarjányi, O., Olasz, K., Hegyi, A., Mikecz, K., & Glant, T. T. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27614 · Cited by 15
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Ortutay, Z., Oksanen, A., Aittomäki, S., Ortutay, C., & Pesu, M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a0514-257rr · Cited by 15
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Coward, J., Germain, R. N., & Altan-Bonnet, G. Y. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005538 · Cited by 15
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Coombs, D., Dushek, O., & van der Merwe, P. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7725-0_2 · Cited by 14
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Norris, P. J., Stone, J. D., Anikeeva, N., Heitman, J. W., Wilson, I. C., Hirschkorn, D. F., Clark, M. J., Moffett, H. F., Cameron, T. O., Sykulev, Y. K., et al. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.09.004 · Cited by 14
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Kim, C., Jay, D. C., & Williams, M. A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004137 · Cited by 13
Roa, N. S., Ordoñez‐Rueda, D., Chávez-Ríos, J. R., Raman, C., García-Zepeda, E. A., Lozano, F., & Soldevila, G. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.086 · Cited by 13
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Schnell, F. J., Alberts‐Grill, N., & Evavold, B. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801798 · Cited by 12
Sarma, U., & Ghosh, I. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-287 · Cited by 12
Rendall, A. D., & Sontag, E. D. (2017) · Royal Society Open Science · doi:10.1098/rsos.170821 · Cited by 12
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Owens, N. D. L., Timmis, J., Greensted, A. J., & Tyrrell, A. M. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.10.017 · Cited by 11
Fuß, H., Dubitzky, W., Downes, C. S., & Kurth, M. J. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.115022 · Cited by 12
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Rettig, L., McNeill, L., Sarner, N., Guillaume, P., Luescher, I. F., Tolaini, M., Kioussis, D., & Zamoyska, R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.121 · Cited by 8
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Matous, J. G., Snook, J. P., Contreras, N. A., Ramstead, A. G., Charley, K. R., Kolawole, E. M., Kisiolek, J. N., Flint, K. A., Soedel, A. J., Robinson, B., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010879 · Cited by 5
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Self-citationZevolini, F., Onnis, A., Khazen, R., Müller, S., Marotta, G., Valitutti, S., Finetti, F., & Baldari, C. T. (2023) · Journal of Cell Science · doi:10.1242/jcs.261476 · Cited by 5
Marrocco, R., Bernard, I., Joulia, E., Barascud, R., Dejean, A. S., Lesourne, R., & Saoudi, A. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05203-5 · Cited by 5
Sim, K. H., Lee, E., Shrestha, P., Choi, B.-H., Hong, J., & Lee, Y. J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116698 · Cited by 6
Wu, L., Gao, A., Lei, Y., Li, J., Mai, K., & Ye, J. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.02.026 · Cited by 5
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Webb, J. T., & Behar, M. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1306 · Cited by 5
Owens, N. D. L. (2010) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 5
Rodriguez-Valbuena, H., Salcedo, J., Thier, O. D., Flot, J., Tiozzo, S., & Tomaso, A. W. D. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2519372122 · Cited by 4
Bharadwaj, N. S. S., Zumwalde, N. A., Kapur, A., Patankar, M. S., & Gumperz, J. E. (2024) · iScience · doi:10.1016/j.isci.2024.109775 · Cited by 4
Cieniewicz, B., Carpino, N., & Krug, L. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090196 · Cited by 4
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Trendel, N., & Dushek, O. (2021) · Springer eBooks · doi:10.1007/978-3-030-57204-4_13 · Cited by 4
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Lu, J. J.-Q., Engl, H. W., Machné, R., & Schuster, P. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-71233-6_14 · Cited by 4
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Kajita, M., Yokota, R., Aihara, K., & Kobayashi, T. (2015) · BIOPHYSICS · doi:10.2142/biophysics.11.85 · Cited by 4
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Frey, A. B. (2007) · Springer eBooks · doi:10.1007/978-0-387-69118-3_5 · Cited by 4
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Yang, S., Santelli, E., Gonzalez, C. G., Johnson, W. T., Choi, I. V., Zhuang, C., Ro, M., Rossitto, L.-A. M., Yu, I., Lin, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw2568 · Cited by 3
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Dunlock, V.-M. E., & Regot, S. (2026) · Science Signaling · doi:10.1126/scisignal.adw3709 · Cited by 3
Neve-Oz, Y., Sherman, E., & Raveh, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412221 · Cited by 4
Callahan, K. P., Mojumdar, A., Hu, M., Wang, A. W., Griffith, A. A., Huang, N., Chua, X. Y., Mroz, N., Puterbaugh, R. Z., Reilly, S. P., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-12951-2 · Cited by 3
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Shah, V., Womack, J. A., Zamora, A. E., Terhune, S. S., & Dash, R. K. (2023) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc40787.2023.10340076 · Cited by 3
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König, R. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00315-6 · Cited by 3
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Vásquez-Montoya, G. A., Danobeitia, J. S., Fernández, L. A., & Hernandez-Ortiz, J. P. (2016) · Transplantation Reviews · doi:10.1016/j.trre.2016.05.002 · Cited by 3
Singh, B., & Rai, A. K. (2022) · Human Immunology · doi:10.1016/j.humimm.2022.10.002 · Cited by 3
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Lindquist, J. A., & Schraven, B. L. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2007_070 · Cited by 3
Tomar, N., & De, R. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080918 · Cited by 3
SHP-1 twelve years on: structure, ligands, substrates and biological roles
Sathish, J. G., & Matthews, R. J. (2003) · Topics in current genetics · doi:10.1007/978-3-540-40035-6_15 · Cited by 3
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Meraner, P., Hořejšı́, V., Wolpl, A., Fischer, G., Stingl, G., & Maurer, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2262 · Cited by 3
Rodriguez-Valbuena, H., Salcedo, J., Their, O. D., Flot, J., Tiozzo, S., & Tomaso, A. W. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.16.618699 · Cited by 3
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Perez-Novo, C. A., Driesen, A., Trimpont, M. V., Theys, C., Logie, E., Vlierberghe, P. V., & Berghe, W. V. (2025) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases3020007 · Cited by 2
Yan, S., Sui, M., Tian, H., Fu, J., Li, Y., Chen, J., Zeng, L., & Ding, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.847512 · Cited by 2
Kirby, D., & Zilman, A. (2025) · Physical review. E · doi:10.1103/physreve.111.024408 · Cited by 2
Metadata
- Authors
- Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Germain, Ronald N.
- Venue
- Nature Immunology
- Published
- 2003-02-10
- Volume
- 4
- Issue
- 3
- Pages
- 248-254
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1971692004
- Cited by
- 465
- References
- 63
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 15 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 19 · 2019: 19 · 2018: 11 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 28 · 2013: 24 · 2012: 28
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- T cell receptor signaling, ligand discrimination, Lck kinase, receptor desensitization, T cell activation, protein tyrosine phosphatase, signal amplification
- MeSH terms
- Animals, Humans, Ligands, Mice, Transgenic, Receptors, Antigen, T-Cell, Signal Transduction, Protein Tyrosine Phosphatases, CD8-Positive T-Lymphocytes, Mitogen-Activated Protein Kinases, Feedback, Physiological, Intracellular Signaling Peptides and Proteins, Mice, Protein Tyrosine Phosphatase, Non-Receptor Type 6
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