Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

Van Gool, Frédéric, Gallí, Mara, Gueydan, Cyril, Kruys, Véronique, Prevot, Pierre-Paul, Bedalov, Antonio, Mostoslavsky, Raul, Alt, Frederick W +2 more·2009·Nature Medicine
DOI 10.1038/nm.1906

Cited by (289)

Items 201–289 of 289

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    Xinru Xue, Yumeng Miao, Zhifeng Wei · 2022 · FEBS Letters
  2. Distinct effects of Nampt inhibition on mild and severe models of lipopolysaccharide-induced myocardial impairment
    Ling Liu, Ping Wang, Canxin Liang, Dongwei He, Ying Yu, Xinwei Liu · 2013 · International Immunopharmacology
  3. Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
    Stacia Rymarchyk, Wenjia Kang, Yana Cen · 2021 · Biomolecules
  4. Ex Vivo Lung Perfusion with β-Nicotinamide Adenine Dinucleotide (NAD+) Improves Ischemic Lung Function
    Jonas Peter Ehrsam, Jin Chen, Héctor Rodríguez Cetina Biefer, Isabelle Opitz, Stephan Arni, İlhan İnci · 2022 · Antioxidants
  5. Niacin inhibits carrageenan-induced neutrophil migration in mice
    Raphael Gomes Ferreira, Tamires Cardoso Matsui, Lindisley Ferreira Gomides, Adriana M. Godin, Gustavo Batista Menezes, Márcio M. Coelho, André Klein · 2013 · Naunyn-Schmiedeberg s Archives of Pharmacology
  6. Sirtuins in Aging and Age-Related Diseases
    Marcia C. Haigis, David A. Sinclair · 2010 · Elsevier eBooks
  7. The role of forkhead box class O3A and SIRT1 gene variants in early-onset psoriasis
    Suzan Demir Pektaş, Gürsoy Doğan, Tuba Edgünlü, Sevim Çelik, Esra Ermiş, Nilgün Solak Tekin · 2018 · Indian Journal of Dermatology
  8. The potential roles of amino acids and their major derivatives in the management of multiple sclerosis
    Somayeh Pashaei, Reza Yarani, Pantea Mohammadi, Mohammad Sajad Emami Aleagha · 2022 · Amino Acids
  9. Pachymic acid modulates sirtuin 6 activity to alleviate lipid metabolism disorders
    Zhisen Pan, Yanling Chen, Kaijia Tang, Zhangzhou Liu, Jia-Li Liang, Yan-Hao Guan, Xiaoyi Xin, Changhui Liu, Chuangpeng Shen · 2023 · Experimental and Therapeutic Medicine
  10. The influential responsibility of sirtuins in senescence and associated diseases: A review
    Deepak Mishra, Lucy Mohapatra, Alok Shiomurti Tripathi, Shravan Kumar Paswan · 2024 · Journal of Biochemical and Molecular Toxicology
  11. Overexpression of SIRT6 in Porcine Fetal Fibroblasts Attenuates Cytotoxicity and Premature Senescence Caused by D-Galactose and Tert-Butylhydroperoxide
    Xiaoxian Xie, Hao Zhang, Ping Gao, Liangliang Wang, Ailing Zhang, Shuihua Xie, Jiaqi Li · 2011 · DNA and Cell Biology
  12. Liver X Receptor (LXR) activation negatively regulates visfatin expression in macrophages
    Thérèse Hervèe Mayi, Elena Rigamonti, François N. Pattou, Bart Staels, Giulia Chinetti · 2010 · Biochemical and Biophysical Research Communications
  13. Sirtuins, Healthspan, and Longevity in Mammals
    William Giblin, David B. Lombard · 2015 · Elsevier eBooks
  14. Down-regulation of serum SIRT6 levels is associated with an increased risk of chronic intestinal inflammation in children exposed to airborne particulate matter and polycyclic aromatic hydrocarbons from e-waste
    Tengyang Huang, Xijin Xu, Shuqin Chen, Zhiping Liu, Yu Huang, Xia Huo, Guangcan Chen · 2025 · Environment International
  15. Modelling the ageing dependence of cancer evolutionary trajectories
    Curtis James Henry, James V. DeGregori · 2025 · Nature reviews. Cancer
  16. Discovery of a Novel Nicotinamide Phosphoribosyl Transferase (NAMPT) Inhibitor via in Silico Screening
    Mikio Takeuchi, Tatsuya Niimi, Mari Masumoto, Masaya Orita, Hiroyuki Yokota, Tomoko Yamamoto · 2013 · Biological and Pharmaceutical Bulletin
  17. MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
    Peixin Huang, Mark W. Lee, Keivan Sadrerafi, Daniel P. Heruth, Li Qin Zhang, Dev Maulik, Shui Qing Ye · 2017 · Drug Design Development and Therapy
  18. Activation of SIRT6 Deacetylation by DNA Strand Breaks
    Wenjia Kang, Abu Hamza, Alyson M. Curry, Evan Korade, Dickson Donu, Yana Cen · 2023 · ACS Omega
  19. Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake
    Awad Saad Alshahrani, Mohammed Al-Dubayee, Mahmoud Zahra, Firas M Alsebayel, Nawaf Alammari, Faisal Abdulmohsen Alsudairy, Muath Almajed, Ahmad Aljada · 2019 · Diabetes Metabolic Syndrome and Obesity
  20. Tumor microenvironment induced switch to mitochondrial metabolism promotes suppressive functions in immune cells
    Sanjay Pandey, Vandana Anang, Michelle M. Schumacher · 2024 · International review of cytology
  21. Vitamin B3 boosts neutrophil counts
    Arati Khanna‐Gupta, Nancy Berliner · 2009 · Nature Medicine
  22. Development of Second Generation Activity-Based Chemical Probes for Sirtuins
    Alyson M. Curry, Elizabeth E. Barton, Wenjia Kang, Daniel V. Mongeluzi, Yana Cen · 2020 · Molecules
  23. Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice
    Xiaoqiang Chen, Tianyou Yuan, Danchuan Zheng, Fangfang Li, Hao Xu, Maoqing Ye, Shaowen Liu, Jun Li · 2025 · Nature Communications
  24. Nicotinamide Phosphoribosyltransferase in Rheumatoid Arthritis
    Daniel P. Heruth, Li Qin Zhang, Shui Qing Ye · 2011 · Journal of Bioanalysis & Biomedicine
  25. Nicotinamide Phosphoribosyltransferase/Pre–B-Cell Colony Enhancing Factor/Visfatin Plasma Levels and Clinical Outcome in Patients With Dilated Cardiomyopathy
    Peter Bobbert, Uwe Kühl, Wolfgang C. Poller, Ursula Rauch, Heinz‐Peter Schultheiß, Carsten Skurk · 2014 · Journal of Cardiac Failure
  26. The Enzymatic Activities of Sirtuins
    Hening Lin · 2018 · Elsevier eBooks
  27. Sirtuin 1 Levels in Recurrent Implantation Failure
    Yaprak Engin Üstün, Ayse Seval Ozgu-Erdinc, Emel Kıyak Çağlayan, Cavidan Gülerman, Esma Sarıkaya, Ayla Aktulay, Canan Demirtas, Salim Erkaya, Nafiye Yılmaz · 2017 · Revista Brasileira Ginecologia e Obstetrícia
  28. Acetylation and deacetylation dynamics in stress response to cancer and infections
    Lili Li, Yanqiong Zeng, Genhong Cheng, Heng Yang · 2025 · Seminars in Immunology
  29. Sirtuins – universal regulators of cell function
    Ігор Петрович Кайдашев · 2012 · Biopolymers and Cell
  30. Relationship of visfatin with obesity and osteoporosis in patients with inflammatory bowel disease: a narrative review
    Alicja Ewa Ratajczak, Aleksandra Szymczak‐Tomczak, Szymon Hryhorowicz, Agnieszka Ewa Zawada, Kinga Skoracka, Anna Maria Rychter, Marzena Skrzypczak-Zielińska, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela‐Kaźmierczak · 2025 · Frontiers in Immunology
  31. Comparative proteomics analysis of midgut samples fromTakifugu rubripesexposed to excessive fluoride: initial molecular response to fluorosis
    Jian John Lu, Qinggang Xu, Huayou Chen, Jun Li, Keping Chen · 2011 · Toxicology Mechanisms and Methods
  32. Sirtuins and the prevention of immunosenescence
    Denise Lasigliè · 2021 · Vitamins and hormones
  33. The Role of Nicotinamide Adenine Dinucleotide in the Pathogenesis of Rheumatoid Arthritis: Potential Implications for Treatment
    Weiqian Chen, Caihong Yi, Jin Lin · 2018 · European Medical Journal
  34. Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
    Marwa O. El-Derany, Diana M. F. Hanna, John Youshia, Enas M. Elmowafy, Mohamed Abdel Fattah Farag, Samar S. Azab · 2023 · Pharmacological Reports
  35. Association between SIRT6 Methylation and Human Longevity in a Chinese Population
    Xu Anna Tang, Yi Wei, Jian Wang, Shiyi Chen, Jiansheng Cai, Jiexia Tang, Xia Xu, Bingshuang Long, Guoqi Yu, Zhiyong Zhang et al. · 2020 · Public Health Genomics
  36. NICOTINAMIDE RIBOSIDE DELIVERY GENERATES NAD+ RESERVES TO PROTECT VASCULAR CELLS AGAINST OXIDATIVE DAMAGE
    Krista Hawrylyshyn, Hao Ran Yin, Caroline H. O’Neil, A. Watson, J. Geoffrey Pickering · 2015 · Canadian Journal of Cardiology
  37. Methods for studying human sirtuins with activity-based chemical probes
    Song Guo Zheng, Jessica Wohlfahrt, Ian Cohen, Yana Cen · 2019 · Methods in enzymology on CD-ROM/Methods in enzymology
  38. Defining a genotoxic profile with mouse embryonic stem cells
    Tae Moon Kim, Vivienne I. Rebel, Paul Hasty · 2013 · Experimental Biology and Medicine
  39. M2-like macrophages and tumor-associated macrophages: overlapping and distinguishing properties en route to a safe therapeutic potential
    Ofer Guttman, Eli C. Lewis · 2016 · Integrative Cancer Science and Therapeutics
  40. Sirtuins, healthspan, and longevity in mammals
    Surinder Kumar, William Giblin, David B. Lombard · 2021 · Elsevier eBooks
  41. Single-Cell RNA sequencing identifies NAMPT as a potential therapeutic target in autoimmune uveitis
    Yingying Wen, Lei Zhu, Zhaohao Huang, Genxian Zhang, Shenqian Tian, Yue Peng, Yihan Zhang, Dongting Wu, Xuling Chen, Gengchen Jiang et al. · 2025 · Journal of Advanced Research
  42. Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency
    Myrto Patraskaki, Najmesadat Seyedkatouli, Lisa Schlicker, Marc O. Warmoes, María Lorena Cordero-Maldonado, Ursula Heins-Marroquin, Carole L. Linster · 2026 · Journal of Inherited Metabolic Disease
  43. Reactive Oxygen Species, Kinase Signaling, and Redox Regulation of Epigenetics
    Isaac Kirubakaran Sundar, Irfan Rahman · 2013 · Springer eBooks
  44. Epigenetic Mechanisms of Sirtuins in Dermatology
    Alexander Lo, Melissa Serravallo, Jared R. Jagdeo · 2015 · Elsevier eBooks
  45. Sirtuins and Mammalian Aging
    Edward H. Sharman · 2010 · Humana Press eBooks
  46. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
    Nica M. Borradaile, Alanna Watson, J. Geoffrey Pickering · 2010 · Elsevier eBooks
  47. Diverse Roles for SIRT6 in Mammalian Healthspan and Longevity
    Bernadette M. M. Zwaans, William Giblin, David B. Lombard · 2016 · Springer eBooks
  48. Possibility of Inhibition of TNF-α/NF-kB Signaling Pathway Activation in Myocardium and Reverse Cardiac Hemodynamics in Chronic Ischemic Heart Disease
    Galenko Iaroshevsky PA, Sukoyan Gv, Ionov DI, Zelenskaya AV, Khvitia NG · 2017 · Journal of Clinical & Experimental Pathology
  49. Métabolisme du NAD et contrôle de la réponse inflammatoire
    Frédéric Van Gool, Mara Gallí, Anthony Rongvaux, Fabienne Andris, Oberdan Léo · 2009 · médecine/sciences
  50. The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues
    Sheryl K. Munro · 2013 · ResearchSpace (University of Auckland)
  51. Faculty Opinions recommendation of SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.
    Vera A. Gorbunova · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  52. Regulation of neutrophil function by NAMPT
    Roberts, Kate · 2013
  53. Investigating the role of nicotinamide phosphoribosyltransferase (NAMPT) in cartilage catabolism
    Laura Evans · 2013 · ORCA Online Research @Cardiff (Cardiff University)
  54. Metabolismo de triptofano em melanomas: o que dizem as células do microambiente?
    Renan Orsati Clara · 2015
  55. Sirtuins as Potential Drug Targets for Metabolic Diseases
    Qiang Tong · 2011
  56. The Role of Sirtuins in Arthritis
    Diego Kyburz, Fabienne Niederer · 2012 · Springer eBooks
  57. Determination of ATP release of human platelets using collagen sepharose resin.
    N Tatsumi, M Niri, Yoichi Furukawa, Tsutomu Inoue, Hiroaki Sagawa, T Yamane · 1987 · PubMed
  58. The Immunoexpression of Visfatin in Oral Carcinogenesis from Korean Patients
    Se-Ra Park, Hye-Yeon Han, Jiyeon Kim, Moon‐Kyoung Bae, Mi Heon Ryu, Soo‐Kyung Bae · 2015 · 대한구강악안면병리학회지
  59. Activación de IL23A y represión de IL12A por metabolitos en la respuesta inmune Th17
    Mario Rodríguez Peña · 2015
  60. Characterization of Sirt2 using conditional RNAi in mice
    Martina Reiss · 2011 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  61. The Role of Sirtuin 6 in Maintaining Vascular Integrity
    Sharon Z Leung · 2016 · Scholarship@Western (Western University)
  62. Ligand Binding and Catalysis in Selected Sirtuin Isozymes
    Junru Yu · 2016 · NDSU Repository (North Dakota State University)
  63. mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
    Michele Cea, Antonia Cagnetta, Mariateresa Fulciniti, Yu‐Tzu Tai, Teru Hideshima, Dharminder Chauhan, Aldo Maria Roccaro, Antonio Sacco, Teresa Calimeri, Francesca Cottini et al. · 2017
  64. The role of adipose secreted cytokines in driving the pathological changes in osteoarthritis
    Ashleigh M. Philp · 2017 · University of Birmingham Institutional Research Archive (University of Birmingham)
  65. The expression of HAT and HDAC enzymes in asthma airways
    Camilla Susannah Laura Tuttle · 2013
  66. Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
    Raymond P. Donnelly · 2016 · Arrow@dit (Dublin Institute of Technology)
  67. Peer Review #1 of "Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice (v0.1)"
    2019 · PeerJ
  68. Case Report 1: NAD+ Oscillation Therapy (NOT) to treat Covid-19 aggravated by poorly controlled Diabetes Melitus Type 2
    Adriaan Francois van Wyk, Theo Verwey · 2020 · Research Square
  69. SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury
    Huitao Liu, Jingjing Zhang, Xingxing Xu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Xiya Shen, Lingting Jin, Sheng Lu et al. · 2020
  70. Der Tryptophanstoffwechsel, seine Metaboliten und damit assoziierte Krankheiten
    Michelle Passarge, Burkhard Schütz · 2021 · Journal für Gynäkologische Endokrinologie/Schweiz
  71. 子宮内膜癌細胞株における抗癌剤感受性の検討(子宮体部悪性腫瘍VI, 第57回日本産科婦人科学会学術講演会)
    真 茂木, 茂樹 新美, 聡 高倉, 聡 柳田, 愛光 岡本, 和徳 落合, 忠夫 田中 · 2005 · 日本産科婦人科學會雜誌
  72. Introduction
    Shrestha Ghosh · 2019 · Springer theses
  73. Nutrition and Cancer
    Vera Christine Mazurak · 2018 · MDPI eBooks
  74. Peer Review #2 of "Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice (v0.1)"
    2019 · PeerJ
  75. Evaluating the expression of IDO and TNF-α and vitamin D levels in diabetic patients cured of MERS-CoV compared to the control groups
    Muna M. Kadam, Z. Al-Abady · 2022 · International Journal of Health Sciences
  76. Nicotinamide Adenine Dinucleotide and Immunoregulation
    Yu-Jie Mou, Zheng-Hong Qin · 2025 · Springer eBooks
  77. An Overview of Nicotinamide Adenine Dinucleotide
    Lijuan Cao, Zheng‐Hong Qin · 2025 · Springer eBooks
  78. The Role of NAD+-Dependent Signal Mechanisms in Cancer Development and Treatment
    Ting Lu, Zheng‐Hong Qin, Junchao Wu · 2025 · Springer eBooks
  79. Serine Promotes Inflammatory Macrophage Polarisation in Periodontitis via NAD + Signalling
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  80. Additional file 1 of Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
    Giovanni Battista Ferrara, Andrea Benzi, Laura Sturla, Daniela Marubbi, Davide Frumento, Sonia Spinelli, Elena Abbotto, Federico Ivaldi, Maria von Holtey, Murone, Maximilien et al. · 2020 · Figshare
  81. Additional file 7 of SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
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  82. The NAMPT Inhibitor FK866 Attenuates DEN-Induced Liver Fibrosis in Mice
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  83. Septic Cardiomyopathy and Mitochondrial Quality Control
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  84. The emerging role of aging in tumorigenesis
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  85. BindingDB Entry 50046646: Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
    BindingDB · 2016 · UC San Diego
  86. BindingDB Entry 50001970: SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
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  87. BindingDB Entry 50044446: Discovery of novel and selective SIRT6 inhibitors.
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  88. BindingDB Entry 50018259: Emerging Therapeutic Potential of SIRT6 Modulators.
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  89. Immunomodulatory Pathways and Metabolism
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