The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
Open accessAbstract
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that flecainide prevents arrhythmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor–mediated Ca2+ release and thereby directly targeting the underlying molecular defect. Flecainide completely prevented CPVT in two human subjects who had remained highly symptomatic on conventional drug therapy, indicating that this currently available drug is a promising mechanism-based therapy for CPVT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Priori, S. G., Napolitano, C., Tiso, N., Memmi, M., Vignati, G., Bloise, R., Sorrentino, V., & Danieli, G. A. (2001) · Circulation · doi:10.1161/01.cir.103.2.196 · Cited by 1,378
Catecholaminergic Polymorphic Ventricular Tachycardia in Children: A 7-Year Follow-up of 21 Patients
Leenhardt, A., Lucet, V., Denjoy, I., Grau, F., Ngoc, D. D., & Coumel, P. (1995) · Circulation · doi:10.1161/01.cir.91.5.1512 · Cited by 1,010
Lahat, H., Pras, E., Olender, T., Avidan, N., Ben-Asher, E., Man, O., Levy-Nissenbaum, E., Khoury, A., Lorber, A., Goldman, B., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/324565 · Cited by 655
Knollmann, B. C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29128 · Cited by 444
Self-citationJiang, D., Xiao, B., Yang, D., Wang, R., Choi, P., Zhang, L., Cheng, H., & Chen, S. R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402388101 · Cited by 440
Left Cardiac Sympathetic Denervation for Catecholaminergic Polymorphic Ventricular Tachycardia
Wilde, A. A. M., Bhuiyan, Z. A., Crotti, L., Facchini, M., De Ferrari, G. M., Paul, T., Ferrandi, C., Koolbergen, D. R., Odero, A., & Schwartz, P. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708006 · Cited by 432
Self-citationPostma, A. V., Denjoy, I., Hoorntje, T. M., Lupoglazoff, J.-M., Da Costa, A., Sebillon, P., Mannens, M. M. A. M., Wilde, A. A. M., & Guicheney, P. (2002) · Circulation Research · doi:10.1161/01.res.0000038886.18992.6b · Cited by 410
Self-citationMechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle.
Marban, E., Robinson, S. W., & Wier, W. G. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112701 · Cited by 316
Arrhythmogenic Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia
Cerrone, M., Noujaim, S. F., Tolkacheva, E. G., Talkachou, A., O’Connell, R., Berenfeld, O., Anumonwo, J., Pandit, S. V., Vikstrom, K., Napolitano, C., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.148064 · Cited by 285
di Barletta, M. R., Viatchenko-Karpinski, S., Nori, A., Memmi, M., Terentyev, D., Turcato, F., Valle, G., Rizzi, N., Napolitano, C., Gyorke, S., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.623793 · Cited by 207
Cited by
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Priori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C.-E., Huikuri, H., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.05.014 · Cited by 1,942
Self-citationPriori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C.-E., Huikuri, H., et al. (2013) · EP Europace · doi:10.1093/europace/eut272 · Cited by 624
Self-citationModernized Classification of Cardiac Antiarrhythmic Drugs
Lei, M., Wu, L., Terrar, D. A., & Huang, C. L.-H. (2018) · Circulation · doi:10.1161/circulationaha.118.035455 · Cited by 319
Plakophilin-2 Is Required for Transcription of Genes That Control Calcium Cycling and Cardiac Rhythm
Cerrone, M., Montnach, J., Lin, X., Zhao, Y.-T., Zhang, M., Agullo-Pascual, E., Leo-Macias, A., Alvarado, F. J., Dolgalev, I., Karathanos, T. V., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00127-0 · Cited by 210
Kirchhof, P., Andresen, D., Bosch, R., Borggrefe, M., Meinertz, T., Parade, U., Ravens, U., Samol, A., Steinbeck, G., Treszl, A., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60570-4 · Cited by 176
Ermakov, S., Gerstenfeld, E. P., Svetlichnaya, Y., & Scheinman, M. M. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2016.12.010 · Cited by 94
Metadata
- Authors
- Watanabe, H., Chopra, N., Laver, D., Hwang, H. S., Davies, S. S., Roach, D. E., Duff, H. J., Roden, D. M., Wilde, A. A. M., & Knollmann, B. C.
- Venue
- Nature Medicine
- Published
- 2009-03-29
- Volume
- 15
- Issue
- 4
- Pages
- 380-383
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2055928084
- Cited by
- 608
- References
- 14
- FWCI
- 35.79
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
