Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

Liu, Jian, Divoux, Adeline, Sun, Jiusong, Zhang, Jie, Clément, Karine, Glickman, Jonathan N, Sukhova, Galina K, Wolters, Paul J +8 more·2009·Nature Medicine
DOI 10.1038/nm.1994

Cited by (795)

Items 701–795 of 795

  1. Re: Brown, Sharma, Ardern, et al., Secular changes in the association between caloric intake, macronutrient intake and physical activity with obesity
    Leo Galland · 2016 · Obesity Research & Clinical Practice
  2. Investigation into the role of innate immunity in murine models of acetaminophen-induced liver injury and diet-induced obesity
    Murphy, Brittany Victoria · 2012
  3. Regulation of Microvascular Insulin-Sensitivity by Perivascular Adipose Tissue: A Translational Approach
    Rick I. Meijer · 2014 · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
  4. Palmitic Acid Activation of Dendritic Cells: Implications for Type 2 Diabetes
    Dequina Nicholas · 2015 · The Scholars Repository - LLU (Loma Linda University)
  5. Bioprospecting for hypoglycemic activities and safety of selected traditionally used plants in the management of diabetes mellitus
    Wycliffe Arika Makori · 2016 · Kenyatta University Institutional Repository (Kenyatta University)
  6. Long-chain n-3 Polyunsaturated Fatty Acids Mitigate Inflammatory Adipokines Derived from Adipocyte-Macrophage Cross-talk and Ensuing Changes in M1-Macrophage Polarization Markers
    Anna De Boer · 2015 · The Atrium (University of Guelph)
  7. The role of macrophage insulin receptor substrate 2 signaling In the regulation of energy homeostasis
    Marie-Therese Rached · 2014 · Spiral (Imperial College London)
  8. Rôle de la synthase inductible du monoxyde d'azote dans les maladies proinflammatoires et la résistance à l'insuline associée à l'obésité
    Carolina Centeno-Baez · 2015
  9. Macrophages Are Regulators of Whole Body Metabolism: A Dissertation
    Joseph C. Yawe · 2016 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  10. Targeting obesity-related inflammation through nutritional and genetic approaches
    Monique J. LeMieux · 2015 · ThinkTech (Texas Tech University)
  11. The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis
    Sezin Dağdeviren · 2016 · eScholarship@UMassChan
  12. Rationale for stem cell therapy for type 2 diabetes mellitus
    Kumar Sushaniba · 2017 · Biomedical Research and Therapy
  13. MorphologicalandInflammatoryChangesinVisceralAdipose Tissue During Obesity
    Xavier S. Revelo, Helen Luck, Shawn Winer, Daniel A. Winer · 2014
  14. Perinatal programming of metabolic dysfunction and obesity-induced inflammation
    Camilla Ingvorsen, Lars Ingvar Hellgren, Susanne Brix · 2013
  15. In Vivo Role of JAK2 in the Pathogenesis of Obesity and the Metabolic Syndrome
    Sally Yu Shi · 2015 · TSpace (University of Toronto)
  16. Ketotifen and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus
    Sahar M. El-Haggar, Wael F. Farrag, Fedaa A. Kotkata · 2017 · Journal of Clinical and Molecular Endocrinology
  17. Endocrine regulation of lipid mobilization in human obesity
    Verboven · 2017
  18. STATUS OF CIRCULATING SERUM TRYPTASE IN HEALTHY OBESE AND COMORBIDLY OBESE CONDITIONS
    Tebeen Nadir, Zhian Salah Ramzi, Saman Hussein Noori, Ban Mousa Rashid, Taha Mahwi, Beston Faiek Nore · 2017 · Journal of Sulaimani Medical College
  19. Obesity: A Complex Disease with Immune Components
    Yuejun Liu, Karine Clément · 2017 · Wiley-VCH eBooks
  20. Fatty Acid and NOD1-mediated Macrophage Polarization: Implications for Metabolic Inflammation and Insulin Resistance
    Kenny L. Chan · 2017 · TSpace (University of Toronto)
  21. Understanding macrophage activation in the adipose tissue: at the crossroads of immunology and metabolism
    Lily Boutens · 2018
  22. The Immediate and Extended Effect of Diet and Exercise on Metabolic Flexibility
    Timothy Daniel Allerton · 2017
  23. Complex interface between immunity and metabolism: The lung as a target organ
    Claudio Procaccini, Veronica De Rosa, Francesco Perna, Giuseppe Matarese · 2018 · Elsevier eBooks
  24. Correlation-based network analysis for biomarkers in obesity
    Pin-Yen Chen, Ping Zhang, Allan W. Cripps, Nicholas P. West, Amanda J. Cox · 2018 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
  25. The inflamed liver
    Bijnen · 2019
  26. Investigating the Wnt/β-catenin Pathway in Conventional Dendritic cells in Obesity-Induced Tissue Inflammation and Insulin Resistance
    Claire E. Macdougall · 2019
  27. Obesity-Induced Mast Cell Infiltration and Activation in Normal Mammary Tissue and Claudin-Low Breast Tumors
    Ottavia Zattra · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  28. The Effects of Early-Life Drug and Dietary Interventions on Late-Life Disease Development
    Theresa Mau · 2019 · Deep Blue (University of Michigan)
  29. The Influence of Overweight- and Obesity-associated Mammary Adipose Inflammation on Progression of Triple-Negative Breast Cancer
    Alyssa Joy Cozzo · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  30. Nutritional Regulation of Inflammation in Obesity and Diabetes
    Xin Wang, Jian Liu · 2020 · Royal Society of Chemistry eBooks
  31. Effects of Leptin Receptor, C-C Chemokine Receptor 2 and Complement Factor 5 Deficiency on Mouse Immunometabolism
    Dario A. Gutierrez · 2012
  32. Inflammation of the Infrapatellar Fat Pad and Knee Osteoarthritis: Investigating the associations with other joint pathologies and pain
    Hemalatha Urban · 2020 · The Sydney eScholarship Repository (The University of Sydney)
  33. Non-coding RNAs Related to Obesity
    Paul Holvoet · 2021 · Springer eBooks
  34. The effect of laparoscopic greater curvature plication on peripheral blood lymphocyte subsets (CD4+, CDS+ T cells) in morbidly obese patients
    Ghada Morshed, Samah M. Fathy · 2013 · Ain Shams Journal of Surgery
  35. Helminth Induced Immunomodulation against Metainflammation and Insulin Resistance
    Vivekanandhan Aravindhan, Joy Manohar Sibi · 2021 · IntechOpen eBooks
  36. Polarized Th2 Cells Attenuates High-Fat-Diet Induced Obesity Through the Suppression of Lipogenesis
    Lijun Dong, Jingtao Gao, Lu Yu, Shibo Liu, Yuxin Zhao, Wen Zhang, Yinming Liang, Hui Wang · 2021 · SSRN Electronic Journal
  37. Immune Regulation of Adipose Tissue Browning
    Andrea Livia Silva Rocha, Luiz Osório Leiria, Tim Julius Schulz, Marcelo A. Mori · 2021 · Springer eBooks
  38. IL-6 as a Surrogate Biomarker: The IL-6 Clinical Value for the Diagnosis of Insulin Resistance and Type 2 Diabetes.
    2021
  39. Tumour Angiogenesis
    Patrícia A. Madureira · 2015 · Springer eBooks
  40. Tumour Angiogenesis
    Patrícia A. Madureira · 2019 · Springer eBooks
  41. Faculty Opinions recommendation of Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue.
    Dennis Daniel Taub, Ana Lustig · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  42. Lipid antigens in adipose tissue
    Robert J. van Eijkeren · 2022
  43. Immune Cells in Adipose Tissue: Key Players in Metabolic Disorders
    Fanny Volat, Anne Bouloumié · 2013 · Springer eBooks
  44. Faculty Opinions recommendation of Impact of CD1d deficiency on metabolism.
    Randy Richard Brutkiewicz, Richard M Gallo · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  45. A Physiological Approach to Inflammatory Markers in Obesity
    Sıla Hidayet Bozdoğan Polat, Nuran Darıyerli · 2022 · BENTHAM SCIENCE PUBLISHERS eBooks
  46. Genetic deletion and pharmacologic inhibition of FcER1 reduces renal injury in mouse models of diabetic nephropathy
    Priyanka Rashmi, Andréa Alice Silva, Tara K. Sigdel, Izabella Damm, Ana Luísa Figueira Gouvêa, Suneil K. Koliwad, Vighnesh Walavalkar, Samy Hakroush, Minnie Sarwal · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Modulação da ativação de macrófagos por fatores secretados por adipócitos NIH3T3-L1 durante a infecção por Mycobacterium bovis BCG, IN VITRO
    Ana Luíza da Silva Albertoni · 2021
  48. Duodenal IgE and mast cells changes in diabetes mellitus patients
    Ethem Ömeroğlu, Ayşe Nur UĞUR KILINÇ · 2024 · Anatolian Current Medical Journal
  49. Bone Marrow Adipose Tissue Is Not Required for Reconstitution of the Immune System Following Irradiation in Male Mice
    Jessica A. Keune, Carmen P. Wong, Adam J. Branscum, Scott A. Menn, Urszula T. Iwaniec, Russell T. Turner · 2024 · International Journal of Molecular Sciences
  50. Identification of key anoikis-related genes and immune cell infiltration characteristics in T2DM based on integrating bioinformatic analysis and machine learning
    Ke K. Zhang, Qifeng Xiao, Wenwen Lu, Xinyuan Tang, Xinhuan Zhang · 2024
  51. Neuropeptides, Inflammation, and Diabetic Wound Healing: Lessons from Experimental Models and Human Subjects
    Lucas Mota, Frank W. LoGerfo, Aristidis Veves, Leena Pradhan‐Nabzdyk · 2024 · Contemporary diabetes
  52. Treinamento físico: estratégica eficaz e segura de redução da inflamação em pacientes com caquexia associada ao câncer.
    Emídio Marques de Matos Neto · 2016
  53. The Sensory Neuron–Mast Cell Axis Regulation of Skin Microcirculation in Diabetes: Implication for Diabetes-Related Cutaneous Complications
    Zhenqi Liu · 2024 · Diabetes
  54. Physiology of the Immune System: Immunology of Adipose Tissue
    Gavin Fredrickson, Saad M. Khan, Daniel A. Winer, Xavier S. Revelo · 2025 · Elsevier eBooks
  55. Multifaceted Roles of Mast Cell-Derived Histamine
    Satoshi Tanaka · 2025 · The Receptors
  56. Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation
    Kimberly A. Negrin · 2014 · eScholarship@UMassChan
  57. Additional file 1 of T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II
    Julia Sbierski‐Kind, David Goldeck, Nikolaus Buchmann, Spranger, Joachim, Volk, Hans-Dieter, Steinhagen-Thiessen, Elisabeth, Graham Pawelec, Demuth, Ilja, Dominik Spira · 2020 · Figshare
  58. Additional file 1 of The involvement of neuroimmune cells in adipose innervation
    Magdalena Blaszkiewicz, Wood, Elizabeth, Sigi Koizar, Willows, Jake, Anderson, Ryan, Tseng, Yu-Hua, James W. Godwin, Kristy L. Townsend · 2020 · Figshare
  59. Additional file 1 of Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis
    Lijun Dong, Gao, Jingtao, Yu, Lu, Liu, Shibo, Zhao, Yuxin, Zhang, Wen, Yinming Liang, Wang, Hui · 2024 · Figshare
  60. Additional file 2 of The involvement of neuroimmune cells in adipose innervation
    Magdalena Blaszkiewicz, Wood, Elizabeth, Sigi Koizar, Willows, Jake, Anderson, Ryan, Tseng, Yu-Hua, James W. Godwin, Kristy L. Townsend · 2020 · Figshare
  61. Mast cell-driven adipocyte lipolysis promotes post-expansive VAT atrophy and ectopic hepatic steatosis
    Jiahui Wang, Lei Zhang, Wen‐Yue Liu, Xin-Zhe Jin, Hao Yin, Hao Cai, Hai‐Yang Yuan, WAH YANG, Bin Bao, Ming‐Hua Zheng et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Targeting Soluble VCAM1 and GSK3β Improves Cerebrovascular Function and Reduces Stroke Pathology in Diabetic Mice
    Masuma Akter Brishti, Mousumi Mandal, Udai Pratap Singh, Tauheed Ishrat, Marie Dennis Leo · 2026 · Cells
  63. Heterogeneity in clinical appearance of chronic spontaneous urticaria: A cross-sectional analysis of a retrospective cohort
    İlkim Deniz Toprak, Şule Çelik Kamacı, Merve Hörmet İğde, Pelin Korkmaz, Nevzat Kahveci, Deniz Eyice Karabacak, Osman Ozan Yeğit, Derya Ünal, Semra Demir, Asli Akkor Gelincik · 2026 · World Allergy Organization Journal
  64. Inflammation intestinale et diabète de type 2 : effet du Resveratrol
    Thi Mai Anh Dao · 2011
  65. Étude de la contribution des récepteurs activés par les proliférateurs de peroxysomes en physiopathologie articulaire
    Meriem Koufany · 2015
  66. La membrane basale du tissu adipeux : son remodelage au cours de l'obésité et sa relation avec l'insulino-résistance
    S. Reggio · 2016
  67. Inflammation du tissu adipeux au cours de l'obésité humaine : implication des lymphocytes Th17
    Charles Caër · 2016 · theses.fr (ABES)
  68. Caractérisation phénotypique et fonctionnelle des trois sous populations de monocytes dans le cadre de l’obésité chez l’homme
    Estelle Devêvre · 2015
  69. Dépôts de graisse ectopique : étude de leur développement et de leur modulation
    Inès Abdesselam · 2016
  70. CD28 : nouvelles données sur un récepteur majeur de la costimulation lymphocytaire T
    Stéphanie O. Morin · 2017 · theses.fr (ABES)
  71. Traitement par leptine recombinante dans les syndromes lipodystrophiques génétiques : effets sur le métabolisme glucido-lipidique
    Camille Vatier · 2017 · theses.fr (ABES)
  72. Rôle du tissu adipeux cutané dans la formation et la cicatrisation de plaies de compression au cours de l'obésité
    Anne-Laure Begey · 2018 · theses.fr (ABES)
  73. Dissémination du cancer de la prostate : un chemin pavé de gras
    Aurélie Toulet · 2018
  74. Etude de trois adipocytokines, adiponectine, visfatine et chémérine au niveau plasmatique et dans plusieurs tissus métaboliques et reproducteurs de différentes espèces
    Namya Mellouk · 2018
  75. Rôle du récepteur adipocytaire des glucocorticoïdes dans les troubles métaboliques liés à un traitement par la corticostérone
    Héloïse Dalle · 2019
  76. Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine
    Perrine Nogues · 2019 · theses.fr (ABES)
  77. Les effets d'une co-exposition à des PCBs (DL et non DL) et au benzo(a)pyrène sur l’adipogénèse et ses répercussions sur l’inflammation in vitro et in vivo
    Phealay May · 2018 · theses.fr (ABES)
  78. Study the role of ASIC3 ion channels in pain hypersensitivities associated with the consumption of lipid rich diet
    Ahmed Negm · 2019
  79. Increased intake of fermentable carbohydrates induces IBS-like symptoms : a complementary understanding of mechanisms involved
    Jasper B. J. Kamphuis · 2019
  80. Adipose tissue senescence in the context of high-fat diet-induced obesity and aging : mechanisms associated with the initiation of cellular senescence
    Zaineb Mezdari · 2021 · theses.fr (ABES)
  81. Arterial hypertension and bronchial asthma: key risk factors
    V. N. Antonov, G. L. Ignatova, V. N. Ivanova · 2026 · Новые Санкт-Петербургские врачебные ведомости.
  82. Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate the Severity of Obesity-Associated White Adipose Tissue and Skeletal Muscle Dysfunction
    Ala Alzubi, Alyssa Lucchesi, Jessie L. Burns, C Young Cho, David W. L. Ma, Lindsay E. Robinson, Jennifer M. Monk · 2026 · Marine Drugs
  83. Diabetic cardiomyopathy: Target immune cell from mechanism to treatment
    Jingyi Lv, Xiaoyi Bao, Xiaolu Jiao, Yue Jiang, Maoning Lin, Wei Zhang, M C Wang · 2026 · International Immunopharmacology
  84. Dynamic Changes in Mast Cell-Derived Histamine and Tryptase Following Reperfusion Therapy in Acute Ischemic Stroke
    Margarita Koeva, Eleonora Kovacheva, Maria Gevezova, Vasilka Kormova, Emanuela P. Kostadinova, Yulia Kostadinova, T. Tsvetanov, Maria Kazakova, Michael H. J. Maes, Victoria S Sarafian · 2026 · The EuroBiotech Journal
  85. Anti-obesity function and related comprehensive molecular mechanisms of probiotics: focus more on mitochondrial dysfunction
    Junyan Zhang, Yao Zhang, Mengjie Wang, Chao Tang, Huimin Yong, Dan Chen, Juan Kan, Jingguo Xu, X S Chen, J Liu · 2026 · Food Bioscience
  86. EGCG combats obesity by triggering a BAT-independent thermogenic switch and remodeling the immune microenvironment in subcutaneous adipose tissue
    Hongen Li, Wentian Lu, Jian Liu, Denghuan Luo, Min Wang, Rongrong Dong, Jun Chu, Qi Chen, Hongyan Wang, Jinbao Huang et al. · 2026 · Phytomedicine
  87. Metabolically Active but Dysfunctional: The Impact of Senescent Cells and SASP
    Kai Xu, Saatvik Viniak, Pratham Viral Shah, Ismihan A Uddin, Zarqa Alam, Md. Wasim Khan · 2026 · Technology in Cancer Research & Treatment
  88. Antidiabetic Properties of Histamine H1 Receptor Antagonists: A Systematic Review
    Michał Radzikowski, Mateusz Maciejczyk · 2026 · Antioxidants
  89. Tissue-Specific Chemerin in Atherosclerosis
    Muyun Chen, Yuxin Li, Feng Linling, Longhua Liu · 2026 · Biomolecules
  90. Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets
    Xiaoli Deng, Yuanyuan Shen, Ying Hao Sun, Lu Lu, Chongkui Sun · 2026 · MedComm
  91. Immunometabolic Memory in Obesity: Nutritional Drivers, Persistence, and Reversibility
    Claudia Reytor-González, Raynier Zambrano-Villacres, Nelly Andrade Mejia, Samuel Durán-Agüero, Daniel Simancas‐Racines · 2026 · International Journal of Molecular Sciences
  92. Caveolin‐1 and CD40L‐CD40‐TRAF interactions in vascular and metabolic disease
    D A Engel · 2012
  93. Role of Inflammation in Diet-Induced Obesity: A Dissertation
    Sophia Kogan · 2013 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  94. L’angiogenèse dans le tissu adipeux
    Anne Bouloumié, Jean Galitzky · 2013 · Springer eBooks
  95. Etude du rôle des sous-populations monocytaires dans l'obésité et l'insulinorésistance
    Sophie Béliard · 2011 · OpenGrey (Institut de l'Information Scientifique et Technique)