The benefits and limitations of animal models for translational research in neurodegenerative diseases
Jucker, Mathias·2010·Nature Medicine
DOI 10.1038/nm.2224
Cited by (399)
Items 301–399 of 399
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- References2018 · Elsevier eBooks
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- Rôle des cellules T CD4+ dans la modulation des réponses microgliales au cours de la maladie d’Alzheimer : potentialités thérapeutiquesDylla Ait Ahmed · 2014 · theses.fr (ABES)
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