The benefits and limitations of animal models for translational research in neurodegenerative diseases

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Van Damme A.

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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A Century of Alzheimer's Disease

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Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Transmission and spreading of tauopathy in transgenic mouse brain

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Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

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Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

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Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

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Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

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Can Animal Models of Disease Reliably Inform Human Studies?

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Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

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Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

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Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice

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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

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Genetic Animal Models of Parkinson's Disease

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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

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Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

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A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

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Missing pieces in the Parkinson's disease puzzle

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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

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Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

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11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

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Animal models of Alzheimer's disease and frontotemporal dementia

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

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Caspase activation precedes and leads to tangles

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Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

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Neuron loss in APP transgenic mice

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Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man

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Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

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Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease

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TAR DNA-binding protein 43 in neurodegenerative disease

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Alzheimer disease models and human neuropathology: similarities and differences

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Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid-β in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain

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“Control” laboratory rodents are metabolically morbid: Why it matters

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Lost in translation: Treatment trials in the SOD1 mouse and in human ALS

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Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β

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Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

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Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

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Guidelines for preclinical animal research in ALS/MND: A consensus meeting

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Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration

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Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

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Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

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Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

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Molecular pathogenesis of Parkinson disease: insights from genetic studies

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Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

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Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

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Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

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Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains*

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Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human α-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy

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Active and passive immunotherapy for neurodegenerative disorders

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Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease

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Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.

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Acute γ-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease

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Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System Degeneration

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β-Amyloid Is Different in Normal Aging and in Alzheimer Disease

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β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease

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In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson's disease?

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Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

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Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.

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Correlating familial Alzheimer’s disease gene mutations with clinical phenotype

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‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

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Mechanism of Cerebral β-Amyloid Angiopathy: Murine and Cellular Models

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Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

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Tauopathy with paired helical filaments in an aged chimpanzee

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Biomarkers in Alzheimer's disease drug development

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Neurofibrillary Tangles and Senile Plaques in Aged Bears

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Axonal Degeneration Induced by Targeted Expression of Mutant Human Tau in Oligodendrocytes of Transgenic Mice That Model Glial Tauopathies

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α-Synucleinopathy models and human neuropathology: similarities and differences

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Knock-out and transgenic mouse models of tauopathies

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Untangling tau-related dementia

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Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice

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Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling

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