The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression
Open accessAbstract
Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to AIDS despite high-level virus replication. We previously showed that the fraction of CD4+CCR5+ T cells is lower in sooty mangabeys compared to humans and macaques. Here we found that, after in vitro stimulation, sooty mangabey CD4+ T cells fail to upregulate CCR5 and that this phenomenon is more pronounced in CD4+ central memory T cells (TCM cells). CD4+ T cell activation was similarly uncoupled from CCR5 expression in sooty mangabeys in vivo during acute SIV infection and the homeostatic proliferation that follows antibody-mediated CD4+ T cell depletion. Sooty mangabey CD4+ TCM cells that express low amounts of CCR5 showed reduced susceptibility to SIV infection both in vivo and in vitro when compared to CD4+ TCM cells of rhesus macaques. These data suggest that low CCR5 expression on sooty mangabey CD4+ T cells favors the preservation of CD4+ T cell homeostasis and promotes an AIDS-free status by protecting CD4+ TCM cells from direct virus infection.
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Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Self-citationDevelopment and Homeostasis of T Cell Memory in Rhesus Macaque
Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. K., & Picker, L. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.29 · Cited by 467
Cited by
Sáez-Cirión, A., Bacchus, C., Hocqueloux, L., Avettand-Fenoel, V., Girault, I., Lecuroux, C., Potard, V., Versmisse, P., Melard, A., Prazuck, T., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003211 · Cited by 1,011
CD 4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
Okoye, A. A., & Picker, L. J. (2013) · Immunological Reviews · doi:10.1111/imr.12066 · Cited by 567
HIV‐associated chronic immune activation
Paiardini, M., & Müller‐Trutwin, M. (2013) · Immunological Reviews · doi:10.1111/imr.12079 · Cited by 451
Self-citationHIV-1 persistence in CD4+ T cells with stem cell–like properties
Buzon, M. J., Sun, H., Li, C., Shaw, A., Seiss, K., Ouyang, Z., Martin-Gayo, E., Leng, J., Henrich, T. J., Li, J. Z., et al. (2014) · Nature Medicine · doi:10.1038/nm.3445 · Cited by 414
Metadata
- Authors
- Paiardini, M., Cervasi, B., Reyes-Aviles, E., Micci, L., Ortiz, A. M., Chahroudi, A., Vinton, C., Gordon, S. N., Bosinger, S. E., Francella, N., Hallberg, P. L., Cramer, E., Schlub, T., Chan, M. L., Riddick, N. E., Collman, R. G., Apetrei, C., Pandrea, I., Else, J., Munch, J., Kirchhoff, F., Davenport, M. P., Brenchley, J. M., & Silvestri, G.
- Venue
- Nature Medicine
- Published
- 2011-06-26
- Volume
- 17
- Issue
- 7
- Pages
- 830-836
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1990668812
- Cited by
- 220
- References
- 2
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- green
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