The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
HIV‐associated chronic immune activation
Open accessAbstract
Summary: Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune activation persists even in HIV‐infected patients in which viral replication is successfully inhibited by anti‐retroviral therapy, with the extent of this residual immune activation being associated with CD 4+ T‐cell loss. Unfortunately, the causal link between chronic immune activation and CD 4+ T‐cell loss has not been formally established. This article provides first a brief historical overview on how the perception of the causative role of immune activation has changed over the years and lists the different kinds of immune activation characteristic of human immunodeficiency virus (HIV) infection. The mechanisms proposed to explain the chronic immune activation are multiple and are enumerated here, as well as the mechanisms proposed on how chronic immune activation could lead to AIDS. In addition, we summarize the lessons learned from natural hosts that know how to ‘show AIDS the door’, and discuss how these studies informed the design of novel immune modulatory interventions that are currently being tested. Finally, we review the current approaches aimed at targeting chronic immune activation and evoke future perspectives.
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Noguera-Julian, M., Rocafort, M., Guillén, Y., Rivera, J., Casadellà, M., Nowak, P., Hildebrand, F., Zeller, G., Parera, M., Bellido, R., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.032 · Cited by 445
Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review
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Metadata
- Authors
- Paiardini, M., & Müller‐Trutwin, M.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2013-06-16
- Volume
- 254
- Issue
- 1
- Pages
- 78-101
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2095050873
- Cited by
- 451
- References
- 170
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
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