The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
Open accessAbstract
Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for the condition because of limited understanding of its pathogenesis. We show that transforming growth factor β1 (TGF-β1) is activated in subchondral bone in response to altered mechanical loading in an anterior cruciate ligament transection (ACLT) mouse model of osteoarthritis. TGF-β1 concentrations are also high in subchondral bone from humans with osteoarthritis. High concentrations of TGF-β1 induced formation of nestin-positive mesenchymal stem cell (MSC) clusters, leading to formation of marrow osteoid islets accompanied by high levels of angiogenesis. We found that transgenic expression of active TGF-β1 in osteoblastic cells induced osteoarthritis, whereas inhibition of TGF-β activity in subchondral bone attenuated the degeneration of articular cartilage. In particular, knockout of the TGF-β type II receptor (TβRII) in nestin-positive MSCs led to less development of osteoarthritis relative to wild-type mice after ACLT. Thus, high concentrations of active TGF-β1 in subchondral bone seem to initiate the pathological changes of osteoarthritis, and inhibition of this process could be a potential therapeutic approach to treating this disease.
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Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179
Latent TGF-β structure and activation
Shi, M., Zhu, J., Wang, R., Chen, X., Mi, L., Walz, T., & Springer, T. A. (2011) · Nature · doi:10.1038/nature10152 · Cited by 1,013
Hunter, D. J., Gerstenfeld, L., Bishop, G., Davis, A. D., Mason, Z. D., Einhorn, T. A., Maciewicz, R. A., Newham, P., Foster, M., Jackson, S., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2601 · Cited by 214
Cited by
Wu, M., Chen, G., & Li, Y.-P. (2016) · Bone Research · doi:10.1038/boneres.2016.9 · Cited by 1,553
Self-citationOsteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Zhang, Y., Xu, J., Ruan, Y. C., Yu, M. K., O'Laughlin, M., Wise, H., Chen, D., Tian, L., Shi, D., Wang, J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4162 · Cited by 1,051
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Xie, H., Cui, Z., Wang, L., Xia, Z., Hu, Y., Xian, L., Li, C., Xie, L., Crane, J., Wan, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3668 · Cited by 951
Self-citationSubchondral bone microenvironment in osteoarthritis and pain
Hu, Y., Chen, X., Wang, S., Jing, Y., & Su, J. (2021) · Bone Research · doi:10.1038/s41413-021-00147-z · Cited by 577
Metadata
- Authors
- Zhen, G., Wen, C., Jia, X., Li, Y., Crane, J. L., Mears, S. C., Askin, F. B., Frassica, F. J., Chang, W., Yao, J., Carrino, J. A., Cosgarea, A., Artemov, D., Chen, Q., Zhao, Z., Zhou, X., Riley, L., Sponseller, P., Wan, M., Lu, W. W., & Cao, X.
- Venue
- Nature Medicine
- Published
- 2013-05-19
- Volume
- 19
- Issue
- 6
- Pages
- 704-712
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2061261019
- Cited by
- 943
- References
- 3
- FWCI
- 41.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhen, G., Wen, C., Jia, X., Li, Y., Crane, J. L., Mears, S. C., Askin, F. B., Frassica, F. J., Chang, W., Yao, J., Carrino, J. A., Cosgarea, A., Artemov, D., Chen, Q., Zhao, Z., Zhou, X., Riley, L., Sponseller, P., Wan, M., . . . Cao, X. (2013). Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nature Medicine. https://doi.org/10.1038/nm.3143
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
