The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
The epigenetics of epithelial-mesenchymal plasticity in cancer
Open accessAbstract
During the course of malignant cancer progression, neoplastic cells undergo dynamic and reversible transitions between multiple phenotypic states, the extremes of which are defined by the expression of epithelial and mesenchymal phenotypes. This plasticity is enabled by underlying shifts in epigenetic regulation. A small cohort of pleiotropically acting transcription factors is widely recognized to effect these shifts by controlling the expression of a constituency of key target genes. These master regulators depend on complex epigenetic regulatory mechanisms, notably the induction of changes in the modifications of chromatin-associated histones, in order to achieve the widespread changes in gene expression observed during epithelial-mesenchymal transitions (EMTs). These associations indicate that an understanding of the functional interactions between such EMT-inducing transcription factors and the modulators of chromatin configuration will provide crucial insights into the fundamental mechanisms underlying cancer progression and may, in the longer term, generate new diagnostic and therapeutic modalities for treating high-grade malignancies.
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1 retracted
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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Self-citationDNA methylation patterns and epigenetic memory
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Epithelial–mesenchymal transitions in tumour progression
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Selective inhibition of BET bromodomains
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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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Cited by
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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876
Self-citationMetastatic colonization by circulating tumour cells
Massagué, J., & Obenauf, A. C. (2016) · Nature · doi:10.1038/nature17038 · Cited by 2,062
Recovering Gene Interactions from Single-Cell Data Using Data Diffusion
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Metadata
- Authors
- Tam, W. L., & Weinberg, R. A.
- Venue
- Nature Medicine
- Published
- 2013-11
- Volume
- 19
- Issue
- 11
- Pages
- 1438-1449
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1991025954
- Cited by
- 1,163
- References
- 170
- FWCI
- 53.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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