The epigenetics of epithelial-mesenchymal plasticity in cancer

Epithelial-Mesenchymal Transitions in Development and Disease

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M., Reinhard, F., Zhang, C. C., Shipitsin, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,672

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124

Epithelial–mesenchymal transitions in tumour progression

Thiery, J. P. (2002) · Nature Reviews Cancer · doi:10.1038/nrc822 · Cited by 6,628

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,218

Selective inhibition of BET bromodomains

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature · doi:10.1038/nature09504 · Cited by 4,262

Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P. J., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,244

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051

Genome Regulation by Long Noncoding RNAs

Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,005

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew-Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,863

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R. A., Come, C., Savagner, P., Gitelman, I., Richardson, A., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,855

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,813

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545

Regulatory networks defining EMT during cancer initiation and progression

Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267

EMT and Dissemination Precede Pancreatic Tumor Formation

Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Cameron, E. E., Bachman, K. E., Myöhänen, S., Herman, J. G., & Baylin, S. B. (1999) · Nature Genetics · doi:10.1038/5047 · Cited by 1,857

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2048 · Cited by 1,804

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

Li, X., Lewis, M. T., Huang, J., Gutierrez, C., Osborne, C. K., Wu, M.-F., Hilsenbeck, S. G., Pavlick, A., Zhang, X., Chamness, G. C., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn123 · Cited by 1,794

The Emergence of lncRNAs in Cancer Biology

Prensner, J. R., & Chinnaiyan, A. M. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0209 · Cited by 1,770

WNT and β-catenin signalling: diseases and therapies

Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Metzger, E., Wissmann, M., Yin, N., Müller, J. M., Schneider, R., Peters, A. H. F. M., Günther, T., Buettner, R., & Schüle, R. (2005) · Nature · doi:10.1038/nature04020 · Cited by 1,733

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

Wellner, U., Schubert, J., Burk, U. C., Schmalhofer, O., Zhu, F., Sonntag, A., Waldvogel, B., Vannier, C., Darling, D., Hausen, A. Z., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1998 · Cited by 1,699

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Kleer, C. G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S. A., Ghosh, D., Sewalt, R. G. A. B., Otte, A. P., Hayes, D. F., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1933744100 · Cited by 1,649

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2

Korpal, M., Lee, E. S., Hu, G., & Kang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800074200 · Cited by 1,645

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

Morel, A.-P., Lièvre, M., Thomas, C., Hinkal, G., Ansieau, S., & Puisieux, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002888 · Cited by 1,645

Pioneer transcription factors: establishing competence for gene expression

Zaret, K. S., & Carroll, J. S. (2011) · Genes & Development · doi:10.1101/gad.176826.111 · Cited by 1,589

TGF-β and epithelial-to-mesenchymal transitions

Zavadil, J., & Böttinger, E. P. (2005) · Oncogene · doi:10.1038/sj.onc.1208927 · Cited by 1,578

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

Onder, T. T., Gupta, P. B., Mani, S. A., Yang, J., Lander, E. S., & Weinberg, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2938 · Cited by 1,522

Induction of tumors in mice by genomic hypomethylation

Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C., & Lander, E. S. (2011) · Cell · doi:10.1016/j.cell.2011.07.026 · Cited by 1,475

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

Creighton, C. J., Li, X., Landis, M., Dixon, J. M., Neumeister, V. M., Sjolund, A., Rimm, D. L., Wong, H., Rodriguez, A., Herschkowitz, J. I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905718106 · Cited by 1,412

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083557 · Cited by 1,399

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

Acloque, H., Adams, M. S., Fishwick, K., Bronner-Fraser, M., & Nieto, M. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38019 · Cited by 1,370

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,310

Polycomb silencers control cell fate, development and cancer

Sparmann, A., & van Lohuizen, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1991 · Cited by 1,303

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,257

Bmi1 is expressed in vivo in intestinal stem cells

Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,194

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

Chaffer, C. L., Brueckmann, I., Scheel, C., Kaestli, A. J., Wiggins, P. A., Rodrigues, L. O., Brooks, M., Reinhardt, F., Su, Y., Polyak, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102454108 · Cited by 1,147

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S., & Yang, J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.022 · Cited by 1,071

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Schwitalla, S., Fingerle, A. A., Cammareri, P., Nebelsiek, T., Göktuna, S. I., Ziegler, P. K., Canli, O., Heijmans, J., Huels, D. J., Moreaux, G., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.012 · Cited by 1,068

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

Bracken, C. P., Gregory, P. A., Kolesnikoff, N., Bert, A. G., Wang, J., Shannon, M. F., & Goodall, G. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1942 · Cited by 1,060

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

Sarrió, D., Rodriguez-Pinilla, S. M., Hardisson, D., Cano, A., Moreno-Bueno, G., & Palacios, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2017 · Cited by 1,056

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,053

The Biology of Cancer Stem Cells

Lobo, N. A., Shimono, Y., Qian, D., & Clarke, M. F. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104154 · Cited by 1,043

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

Micalizzi, D. S., Farabaugh, S. M., & Ford, H. L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9178-9 · Cited by 984

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

Ocaña, O. H., Córcoles, R., Fabra, Á., Moreno-Bueno, G., Acloque, H., Vega, S., Barrallo-Gimeno, A., Cano, A., & Nieto, M. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.012 · Cited by 973

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

Guo, W., Keckesova, Z., Donaher, J. L., Shibue, T., Tischler, V., Reinhardt, F., Itzkovitz, S., Noske, A., Zürrer-Härdi, U., Bell, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.008 · Cited by 957

MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

Kasinski, A. L., & Slack, F. J. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3166 · Cited by 936

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Daigle, S. R., Olhava, E. J., Therkelsen, C. A., Majer, C. R., Sneeringer, C. J., Song, J., Johnston, L. D., Scott, M. P., Smith, J. J., Xiao, Y., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.009 · Cited by 923

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

Chaffer, C. L., Marjanovic, N. D., Lee, T., Bell, G., Kleer, C. G., Reinhardt, F., D’Alessio, A. C., Young, R. A., & Weinberg, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.06.005 · Cited by 876

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

Scheel, C., Eaton, E. N., Li, S. H.-J., Chaffer, C. L., Reinhardt, F., Kah, K.-J., Bell, G., Guo, W., Rubin, J., Richardson, A. L., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.029 · Cited by 858

Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression

Moustakas, A., & Heldin, C. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00550.x · Cited by 804

The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

Brabletz, S., & Brabletz, T. (2010) · EMBO reports · doi:10.1038/embor.2010.117 · Cited by 793

Triple-negative breast cancer: disease entity or title of convenience?

Carey, L., Winer, E., Viale, G., Cameron, D., & Gianni, L. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.154 · Cited by 783

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Knutson, S. K., Wigle, T. J., Warholic, N. M., Sneeringer, C. J., Allain, C. J., Klaus, C. R., Sacks, J. D., Raimondi, A., Majer, C. R., Song, J., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1084 · Cited by 776

Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex

Peinado, H., Ballestar, E., Esteller, M., & Cano, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.306-319.2004 · Cited by 763

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

Chang, C.-J., Chao, C.-H., Xia, W., Yang, J.-Y., Xiong, Y., Li, C.-W., Yu, W.-H., Rehman, S. K., Hsu, J. L., Lee, H.-H., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2173 · Cited by 745

Stem Cells and Cancer

Valk-Lingbeek, M. E., Bruggeman, S. W. M., & van Lohuizen, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.005 · Cited by 743

microRNAs in cancer management

Kong, Y. W., Ferland-McCollough, D., Jackson, T. J., & Bushell, M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70073-6 · Cited by 734

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

Nieto, M. A. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154036 · Cited by 720

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

Wang, Y., Zhang, H., Chen, Y., Sun, Y., Yang, F., Yu, W., Liang, J., Sun, L., Yang, X., Shi, L., et al. (2009) · Cell · doi:10.1016/j.cell.2009.05.050 · Cited by 692

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

Schenk, T., Chen, W. C., Göllner, S., Howell, L., Jin, L., Hebestreit, K., Klein, H.-U., Popescu, A. C., Burnett, A., Mills, K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2661 · Cited by 672

Brca1 breast tumors contain distinct CD44+/CD24- and CD133+cells with cancer stem cell characteristics

Wright, M. H., Calcagno, A. M., Salcido, C. D., Carlson, M. D., Ambudkar, S. V., & Varticovski, L. (2008) · Breast Cancer Research · doi:10.1186/bcr1855 · Cited by 642

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

Yang, M.-H., Hsu, D. S.-S., Wang, H.-W., Wang, H.-J., Lan, H.-Y., Yang, W.-H., Huang, C.-H., Kao, S.-Y., Tzeng, C.-H., Tai, S.-K., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2099 · Cited by 631

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

Oft, M., Heider, K.-H., & Beug, H. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00533-7 · Cited by 623

To differentiate or not — routes towards metastasis

Brabletz, T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3265 · Cited by 623

A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells

Yook, J. I., Li, X.-Y., Ota, I., Hu, C., Kim, H. S., Kim, N. H., Cha, S. Y., Ryu, J. K., Choi, Y. J., Kim, J., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1508 · Cited by 616

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

Cao, Q., Yu, J., Dhanasekaran, S. M., Kim, J. H., Mani, R.-S., Tomlins, S. A., Mehra, R., Laxman, B., Cao, X., Yu, J., et al. (2008) · Oncogene · doi:10.1038/onc.2008.333 · Cited by 583

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

Blanco, M. J., Moreno-Bueno, G., Sarrio, D., Locascio, A., Cano, A., Palacios, J., & Nieto, M. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205416 · Cited by 576

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

Harris, W. J., Huang, X., Lynch, J. T., Spencer, G. J., Hitchin, J. R., Li, Y., Ciceri, F., Blaser, J. G., Greystoke, B. F., Jordan, A. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.014 · Cited by 566

Neural crest delamination and migration: From epithelium-to-mesenchyme transition to collective cell migration

Theveneau, E., & Mayor, R. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2011.12.041 · Cited by 535

Polycomb group proteins: navigators of lineage pathways led astray in cancer

Bracken, A. P., & Helin, K. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2736 · Cited by 523

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

Savagner, P., Yamada, K. M., & Thiery, J. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1403 · Cited by 520

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment

Daskalakis, M., Nguyen, T. T., Nguyen, C., Guldberg, P., Köhler, G., Wijermans, P., Jones, P. A., & Lübbert, M. (2002) · Blood · doi:10.1182/blood.v100.8.2957 · Cited by 514

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

Kim, T., Veronese, A., Pichiorri, F., Lee, T. J., Jeon, Y.-J., Volinia, S., Pineau, P., Marchio, A., Palatini, J., Suh, S.-S., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110235 · Cited by 514

Bmi1, stem cells, and senescence regulation

Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420800 · Cited by 495

Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

Mulholland, D. J., Kobayashi, N., Ruscetti, M., Zhi, A., Tran, L. M., Huang, J., Gleave, M., & Wu, H. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3132 · Cited by 478

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

Lim, S., Janzer, A., Becker, A., Zimmer, A., Schüle, R., Buettner, R., & Kirfel, J. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp324 · Cited by 470

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

Dong, C., Wu, Y., Yao, J., Wang, Y., Yu, Y., Rychahou, P. G., Evers, B. M., & Zhou, B. P. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57349 · Cited by 464

Cell contact during early morphogenesis in the chick embryo

Trelstad, R. L., Hay, E. D., & Revel, J.-P. (1967) · Developmental Biology · doi:10.1016/0012-1606(67)90018-8 · Cited by 463

β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

Sánchez-Tilló, E., de Barrios, O., Siles, L., Cuatrecasas, M., Castells, A., & Postigo, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108977108 · Cited by 448

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

Herranz, N., Pasini, D., Díaz, V. M., Francí, C., Gutierrez, A., Dave, N., Escrivà, M., Hernandez-Muñoz, I., Di Croce, L., Helin, K., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00323-08 · Cited by 437

DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT

Kim, K., Lu, Z., & Hay, E. D. (2002) · Cell Biology International · doi:10.1006/cbir.2002.0901 · Cited by 428

Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/“triple-negative” breast cancer cell lines growing in vitro

Finn, R. S., Dering, J., Ginther, C., Wilson, C. A., Glaspy, P., Tchekmedyian, N., & Slamon, D. J. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9463-x · Cited by 409

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

Chang, C.-J., Yang, J.-Y., Xia, W., Chen, C.-T., Xie, X., Chao, C.-H., Woodward, W. A., Hsu, J.-M., Hortobagyi, G. N., & Hung, M.-C. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.10.035 · Cited by 408

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.013 · Cited by 399

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

Song, L.-B., Li, J., Liao, W.-T., Feng, Y., Yu, C.-P., Hu, L.-J., Kong, Q.-L., Xu, L.-H., Zhang, X., Liu, W.-L., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39374 · Cited by 398

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

McDonald, O. G., Wu, H., Timp, W., Doi, A., & Feinberg, A. P. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2084 · Cited by 379

Autocrine PDGFR signaling promotes mammary cancer metastasis

Jechlinger, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24652 · Cited by 371

The ZEB1/miR‐200 feedback loop controls Notch signalling in cancer cells

Brabletz, S., Bajdak, K., Meidhof, S., Burk, U., Niedermann, G., Firat, E., Wellner, U., Dimmler, A., Faller, G., Schubert, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.349 · Cited by 369

Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer

Wiklund, E. D., Bramsen, J. B., Hulf, T., Dyrskjøt, L., Ramanathan, R., Hansen, T. B., Villadsen, S. B., Gao, S., Ostenfeld, M. S., Borre, M., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.25461 · Cited by 367

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1

Lin, Y., Wu, Y., Li, J., Dong, C., Ye, X., Chi, Y., Evers, B. M., & Zhou, B. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.63 · Cited by 361

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

von Burstin, J., Eser, S., Paul, M. C., Seidler, B., Brandl, M., Messer, M., von Werder, A., Schmidt, A., Mages, J., Pagel, P., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.004 · Cited by 356

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

Davalos, V, Moutinho, C., Villanueva, A., Boque, R., Silva, P., Carneiro, F., & Esteller, M. (2012) · Oncogene · doi:10.1038/onc.2011.383 · Cited by 351

Multilayer control of the EMT master regulators

Zheng, H., & Kang, Y. (2014) · Oncogene · doi:10.1038/onc.2013.128 · Cited by 346

Polycomb, Epigenomes, and Control of Cell Identity

Orlando, V. (2003) · Cell · doi:10.1016/s0092-8674(03)00157-0 · Cited by 340

Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E2 Signaling

Li, H.-J., Reinhardt, F., Herschman, H. R., & Weinberg, R. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0101 · Cited by 340

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

Tam, W. L., Lu, H., Buikhuisen, J., Soh, B. S., Lim, E., Reinhardt, F., Wu, Z. J., Krall, J. A., Bierie, B., Guo, W., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.005 · Cited by 321

Epithelial mesenchymal transition traits in human breast cancer cell lines

Blick, T., Widodo, E., Hugo, H., Waltham, M., Lenburg, M. E., Neve, R. M., & Thompson, E. W. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9170-6 · Cited by 314

Loss of miR-200c Expression Induces an Aggressive, Invasive, and Chemoresistant Phenotype in Non–Small Cell Lung Cancer

Ceppi, P., Mudduluru, G., Kumarswamy, R., Rapa, I., Scagliotti, G. V., Papotti, M., & Allgayer, H. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0052 · Cited by 303

Transactivation of Vimentin by Beta-Catenin in Human Breast Cancer Cells

Gilles, C., Polette, M., Mestdagt, M., Nawrocki-Raby, B., Ruggeri, P., Birembaut, P., & Foidart, J.-M. (2003) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-00009577-200303001-00219 · Cited by 301

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

Liu, B. Y., McDermott, S. P., Khwaja, S. S., & Alexander, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400699101 · Cited by 293

Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

Blick, T., Hugo, H., Widodo, E., Waltham, M., Pinto, C., Mani, S. A., Weinberg, R. A., Neve, R. M., Lenburg, M. E., & Thompson, E. W. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9175-z · Cited by 292

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

Lin, T., Ponn, A., Hu, X., Law, B. K., & Lu, J. (2010) · Oncogene · doi:10.1038/onc.2010.234 · Cited by 291

Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

Lehmann, K., Janda, E., Pierreux, C. E., Rytömaa, M., Schulze, A., McMahon, M., Hill, C. S., Beug, H., & Downward, J. (2000) · Genes & Development · doi:10.1101/gad.181700 · Cited by 287

The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis

Fu, J., Qin, L., He, T., Qin, J., Hong, J., Wong, J., Liao, L., & Xu, J. (2011) · Cell Research · doi:10.1038/cr.2010.118 · Cited by 286

Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells

Vrba, L., Jensen, T. J., Garbe, J. C., Heimark, R. L., Cress, A. E., Dickinson, S., Stampfer, M. R., & Futscher, B. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008697 · Cited by 285

A Poised Chromatin Platform for TGF-β Access to Master Regulators

Xi, Q., Wang, Z., Zaromytidou, A.-I., Zhang, X. H.-F., Chow-Tsang, L.-F., Liu, J. X., Kim, H., Barlas, A., Manova-Todorova, K., Kaartinen, V., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.032 · Cited by 285

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

Bonde, A.-K., Tischler, V., Kumar, S., Soltermann, A., & Schwendener, R. A. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-35 · Cited by 283

EMT and Stem Cell–Like Properties Associated with miR-205 and miR-200 Epigenetic Silencing Are Early Manifestations during Carcinogen-Induced Transformation of Human Lung Epithelial Cells

Tellez, C. S., Juri, D. E., Do, K., Bernauer, A. M., Thomas, C. L., Damiani, L. A., Tessema, M., Leng, S., & Belinsky, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3035 · Cited by 277

Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer.

Collett, K., Eide, G. E., Arnes, J., Stefansson, I. M., Eide, J., Braaten, A., Aas, T., Otte, A. P., & Akslen, L. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1533 · Cited by 272

miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells

Eades, G., Yao, Y., Yang, M., Zhang, Y., Chumsri, S., & Zhou, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229401 · Cited by 263

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

Mills, A. A. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2931 · Cited by 249

Stem cell regulation by polycomb repressors: postponing commitment

Pietersen, A. M., & van Lohuizen, M. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.004 · Cited by 248

Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (Review)

Katoh (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000019 · Cited by 234

The emerging functions of histone demethylases

Agger, K., Christensen, J., Cloos, P. A., & Helin, K. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.12.003 · Cited by 231

The Pathophysiology of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β in Normal and Malignant Mammary Epithelial Cells

Taylor, M. A., Parvani, J. G., & Schiemann, W. P. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9181-1 · Cited by 231

E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells

Tryndyak, V. P., Beland, F. A., & Pogribny, I. P. (2010) · International Journal of Cancer · doi:10.1002/ijc.24972 · Cited by 224

Distinct mechanisms of TGF- 1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

Han, G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24399 · Cited by 224

Plasticity of disseminating cancer cells in patients with epithelial malignancies

Bednarz-Knoll, N., Alix-Panabières, C., & Pantel, K. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9370-z · Cited by 214

Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer

Dong, C., Wu, Y., Wang, Y., Wang, C., Kang, T., Rychahou, P. G., Chi, Y.-I., Evers, B. M., & Zhou, B. P. (2013) · Oncogene · doi:10.1038/onc.2012.169 · Cited by 214

A systems view of epithelial–mesenchymal transition signaling states

Thomson, S., Petti, F., Sujka-Kwok, I., Mercado, P., Bean, J., Monaghan, M., Seymour, S. L., Argast, G. M., Epstein, D. M., & Haley, J. D. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9367-3 · Cited by 211

Transactivation of vimentin by beta-catenin in human breast cancer cells.

Gilles, C., Polette, M., Mestdagt, M., et al. (2003) · PubMed · Cited by 210

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

Morel, A.-P., Hinkal, G. W., Thomas, C., Fauvet, F., Courtois-Cox, S., Wierinckx, A., Devouassoux-Shisheboran, M., Treilleux, I., Tissier, A., Gras, B., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002723 · Cited by 207

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

Vallés, A. M., Boyer, B., Badet, J., Tucker, G. C., Barritault, D., & Thiery, J. P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1124 · Cited by 207

Regional Activation of the Cancer Genome by Long-Range Epigenetic Remodeling

Bert, S. A., Robinson, M. D., Strbenac, D., Statham, A. L., Song, J. Z., Hulf, T., Sutherland, R. L., Coolen, M. W., Stirzaker, C., & Clark, S. J. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.006 · Cited by 201

Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer

Zouridis, H., Deng, N., Ivanova, T., Zhu, Y., Wong, B., Huang, D., Wu, Y. H., Wu, Y., Tan, I. B., Liem, N., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004504 · Cited by 186

Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity

Coolen, M. W., Stirzaker, C., Song, J. Z., Statham, A. L., Kassir, Z., Moreno, C. S., Young, A. N., Varma, V., Speed, T. P., Cowley, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2023 · Cited by 183

Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

Neves, R., Scheel, C., Weinhold, S., Honisch, E., Iwaniuk, K. M., Trompeter, H.-I., Niederacher, D., Wernet, P., Santourlidis, S., & Uhrberg, M. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-219 · Cited by 178

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

van Zijl, F., Mair, M., Csiszar, A., Schneller, D., Zulehner, G., Huber, H., Eferl, R., Beug, H., Dolznig, H., & Mikulits, W. (2009) · Oncogene · doi:10.1038/onc.2009.253 · Cited by 175

β‐catenin signaling marks the prospective site of primitive streak formation in the mouse embryo

Mohamed, O. A., Clarke, H. J., & Dufort, D. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20135 · Cited by 174

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

Arnoux, V., Nassour, M., L'Helgoualc'h, A., Hipskind, R. A., & Savagner, P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1078 · Cited by 172

Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases

Chao, Y., Wu, Q., Acquafondata, M., Dhir, R., & Wells, A. (2012) · Cancer Microenvironment · doi:10.1007/s12307-011-0085-4 · Cited by 169

ErbB/EGF Signaling and EMT in Mammary Development and Breast Cancer

Hardy, K. M., Booth, B. W., Hendrix, M. J. C., Salomon, D. S., & Strizzi, L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9172-2 · Cited by 164

Stabilization of β-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast

Kemler, R., Hierholzer, A., Kanzler, B., Kuppig, S., Hansen, K., Taketo, M. M., de Vries, W. N., Knowles, B. B., & Solter, D. (2004) · Development · doi:10.1242/dev.01458 · Cited by 162

Platelet-Derived Growth Factor-D Overexpression Contributes to Epithelial-Mesenchymal Transition of PC3 Prostate Cancer Cells

Kong, D., Wang, Z., Sarkar, S. H., Li, Y., Banerjee, S., Saliganan, A. D., Kim, H.-R. C., Cher, M. L., & Sarkar, F. H. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1076 · Cited by 160

Slug Is Required for Cell Survival during Partial Epithelial-Mesenchymal Transition of HGF-induced Tubulogenesis

Leroy, P., & Mostov, K. E. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0823 · Cited by 159

HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT

Bruzzese, F., Leone, A., Rocco, M., Carbone, C., Piro, G., Caraglia, M., Gennaro, E. D., & Budillon, A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22574 · Cited by 143

Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor SuppressorsPreprint

Pardal, R., Molofsky, A. V., He, S., & Morrison, S. J. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.057 · Cited by 134

Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelial–mesenchymal transition-like state in breast cancer cells in vitro

Gao, M., Kim, B. G., Kang, S., Choi, Y. P., Park, H., Kang, K. S., & Cho, N. H. (2010) · Journal of Cell Science · doi:10.1242/jcs.072900 · Cited by 134

ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features

Albino, D., Longoni, N., Curti, L., Grand, M. M., Pinton, S., Civenni, G., Thalmann, G. N., D’Ambrosio, G., Sarti, M., Sessa, F., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0212 · Cited by 125

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Puppe, J., Drost, R., Liu, X., Joosse, S. A., Evers, B., Cornelissen‐Steijger, P., Nederlof, P. M., Yu, Q., Jonkers, J., van Lohuizen, M., et al. (2009) · Breast Cancer Research · doi:10.1186/bcr2354 · Cited by 117

Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis

Sangiorgi, E., & Capecchi, M. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902508106 · Cited by 111

Tumorigenesis: Twist1 links EMT to self-renewal

Martín, A., & Cano, A. (2010) · Nature Cell Biology · doi:10.1038/ncb1010-924 · Cited by 109

Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium

Maruyama, R., Choudhury, S., Kowalczyk, A., Bessarabova, M., Beresford-Smith, B., Conway, T., Kaspi, A., Wu, Z., Nikolskaya, T., Merino, V. F., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001369 · Cited by 108

Histone Deacetylase Inhibitors Induce Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells

Kong, D., Ahmad, A., Bao, B., Li, Y., Banerjee, S., & Sarkar, F. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045045 · Cited by 107

Shutting down Wnt signal–activated cancer

Taketo, M. M. (2004) · Nature Genetics · doi:10.1038/ng0404-320 · Cited by 103

Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2′-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells

Shaker, S., Bernstein, M. L., Momparler, L. F., & Momparler, R. L. (2003) · Leukemia Research · doi:10.1016/s0145-2126(02)00222-9 · Cited by 102

Histone deacetylase inhibitor induction of epithelial–mesenchymal transitions via up-regulation of Snail facilitates cancer progression

Jiang, G., Wang, H., Zhang, F., Zhang, K.-S., Liu, Z., Fang, R., Wang, H., Cai, S., & Du, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.12.002 · Cited by 100

Regulation of Slug transcription in embryonic ectoderm by β‐catenin‐Lef/Tcf and BMP‐Smad signaling

Sakai, D., Tanaka, Y., Endo, Y., Osumi, N., Okamoto, H., & Wakamatsu, Y. (2005) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2005.00821.x · Cited by 97

The epithelial cell default‐phenotype hypothesis and its implications for cancer

Frisch, S. M. (1997) · BioEssays · doi:10.1002/bies.950190811 · Cited by 95

Histone Deacetylase Inhibition Suppresses the Transforming Growth Factor β1-Induced Epithelial-to-Mesenchymal Transition in Hepatocytes†,‡

Kaimori, A., Potter, J. J., Choti, M. A., Ding, Z., Mezey, E., & Koteish, A. A. (2010) · Hepatology · doi:10.1002/hep.23765 · Cited by 84

Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells

Ke, X., Qu, Y., Yang, C. Z., Li, W., Rotter, V., Oyan, A. M., & Kalland, K. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-669 · Cited by 82

Histone deacetylase 1 is required for transforming growth factor-β1-induced epithelial–mesenchymal transition

Lei, W., Zhang, K., Pan, X., Hu, Y., Wang, D., Yuan, X., Shu, G., & Song, J. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.05.006 · Cited by 80

Comment on "Chromosomal Instability and Tumors Promoted by DNA Hypomethylation" and "Induction of Tumors in Mice by Genomic Hypomethylation"

Yang, A. S., Estecio, M. R., Garcia‐Manero, G., Kantarjian, H. M., & Issa, J. J. (2003) · Science · doi:10.1126/science.1089523 · Cited by 72

Complete remission through blast cell differentiation inPLZF/RARα-positive acute promyelocytic leukemia: in vitro and in vivo studies

Petti, M. C., Fazi, F., Gentile, M., et al. (2002) · Blood · doi:10.1182/blood-2001-12-0368 · Cited by 67

An Unstable Liaison

Christoph Lengauer, C. (2003) · Science · doi:10.1126/science.1084468 · Cited by 46

KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570

Chaix, A., Arcangeli, M.-L., Lopez, S., Voisset, E., Yang, Y., Vita, M. D., Letard, S., Audebert, S., Finetti, P., Birnbaum, D., et al. (2013) · Oncogene · doi:10.1038/onc.2013.12 · Cited by 26

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876

Metastatic colonization by circulating tumour cells

Massagué, J., & Obenauf, A. C. (2016) · Nature · doi:10.1038/nature17038 · Cited by 2,062

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

van Dijk, D., Sharma, R., Nainys, J., Yim, K., Kathail, P., Carr, A. J., Burdziak, C., Moon, K. R., Chaffer, C. L., Pattabiraman, D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.061 · Cited by 1,829

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791