The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
Open accessAbstract
We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein). Both the MPRIP-NTRK1 and CD74-NTRK1 fusions lead to constitutive TRKA kinase activity and are oncogenic. Treatment of cells expressing NTRK1 fusions with inhibitors of TRKA kinase activity inhibited autophosphorylation of TRKA and cell growth. Tumor samples from 3 of 91 patients with lung cancer (3.3%) without known oncogenic alterations assayed by next-generation sequencing or fluorescence in situ hybridization demonstrated evidence of NTRK1 gene fusions.
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The Sequence Alignment/Map format and SAMtools
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Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma
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Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
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Crizotinib versus Chemotherapy in Advanced ALK -Positive Lung Cancer
Shaw, A. T., Kim, D.-W., Nakagawa, K., Seto, T., Crinó, L., Ahn, M.-J., De Pas, T., Besse, B., Solomon, B. J., Blackhall, F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214886 · Cited by 3,381
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Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
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Self-citationDoebele, R. C., Drilon, A., Paz-Ares, L., Siena, S., Shaw, A. T., Farago, A. F., Blakely, C. M., Seto, T., Cho, B. C., Tosi, D., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30691-6 · Cited by 1,790
Self-citationDistinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
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The target landscape of clinical kinase drugs
Klaeger, S., Heinzlmeir, S., Wilhelm, M., Polzer, H., Vick, B., Koenig, P.-A., Reinecke, M., Ruprecht, B., Petzoldt, S., Meng, C., et al. (2017) · Science · doi:10.1126/science.aan4368 · Cited by 854
Metadata
- Authors
- Vaishnavi, A., Capelletti, M., Le, A. T., Kako, S., Butaney, M., Ercan, D., Mahale, S., Davies, K. D., Aisner, D. L., Pilling, A. B., Berge, E. M., Kim, J., Sasaki, H., Park, S.-I., Kryukov, G., Garraway, L. A., Hammerman, P. S., Haas, J., Andrews, S. W., Lipson, D., Stephens, P. J., Miller, V. A., Varella-Garcia, M., Jänne, P. A., & Doebele, R. C.
- Venue
- Nature Medicine
- Published
- 2013-10-27
- Volume
- 19
- Issue
- 11
- Pages
- 1469-1472
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1975784282
- Cited by
- 607
- References
- 8
- FWCI
- 33.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Vaishnavi, A., Capelletti, M., Le, A. T., Kako, S., Butaney, M., Ercan, D., Mahale, S., Davies, K. D., Aisner, D. L., Pilling, A. B., Berge, E. M., Kim, J., Sasaki, H., Park, S.-I., Kryukov, G., Garraway, L. A., Hammerman, P. S., Haas, J., Andrews, S. W., . . . Doebele, R. C. (2013). Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nature Medicine. https://doi.org/10.1038/nm.3352
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
